geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

ED50 study of femtosecond terawatt laser pulses on porcine skin


, : ED50 study of femtosecond terawatt laser pulses on porcine skin. Lasers in Surgery and Medicine 37(1): 59-63

Terawatt (TW) lasers have become commonplace since the development of the chirped-pulse amplification method using Ti:sapphire and Nd:glass laser rods. We have measured the minimum visible lesion (MVL) thresholds for porcine1The animals involved in this study were procured, maintained, and used in accordance with the Federal Animal Welfare Act and the "Guide for the Care and Use of Laboratory Animals" prepared by the Institute of Laboratory Animal Resources-National Research Council. Brooks City-Base, TX has been fully accredited by the Association for Assessment and Accreditation of Laboratory Animal Care, International (AAALAC) since 1967. (Yucatan mini-pig) skin using TW laser pulses. Our system produced laser pulses at 810 nm and sub-50 femtoseconds. These 1-2 TW laser pulses created multiple self-focusing (SF) filaments during propagation and were directed on the flanks of mini-pigs under anesthesia. We measured the pulse energies necessary to determine the ED(50) skin damage thresholds. The MVL ED(50) threshold at 1 hour was 8 mJ and increased to 21 mJ after 24 hours. Histological sections were obtained after 1-hour and 24-hour readings. The damage patterns on the skin indicated the number of filaments in the laser pulse. Many of the pulses produced only superficial damage that disappeared in 24 hours and that nearly three times the pulse energy was required to cause subdural or cellular damage. With further research, non-thermal tissue ablation using TW laser pulses could provide a viable alternative to current techniques of laser use in dermatology.

US$19.90

PMID: 15954120

DOI: 10.1002/lsm.20195


Other references

Bauersachs, J., 2009: Aldosterone antagonists for all patients with heart failure?. Mmw Fortschritte der Medizin 151(15): 33-35

Baldridge, D.; Schwarze, U.; Morello, R.; Lennington, J.; Bertin, T.K.; Pace, J.M.; Pepin, M.G.; Weis, M.; Eyre, D.R.; Walsh, J.; Lambert, D.; Green, A.; Robinson, H.; Michelson, M.; Houge, G.; Lindman, C.; Martin, J.; Ward, J.; Lemyre, E.; Mitchell, J.J.; Krakow, D.; Rimoin, D.L.; Cohn, D.H.; Byers, P.H.; Lee, B., 2008: CRTAP and LEPRE1 mutations in recessive osteogenesis imperfecta. Autosomal dominant osteogenesis imperfecta (OI) is caused by mutations in the genes (COL1A1 or COL1A2) encoding the chains of type I collagen. Recently, dysregulation of hydroxylation of a single proline residue at position 986 of both the triple-...

Kunder, C.A.; Roncador, G.; Advani, R.H.; Gualco, G.; Bacchi, C.E.; Sabile, J.M.; Lossos, I.S.; Nie, K.; Tibshirani, R.John.; Green, M.R.; Alizadeh, A.A.; Natkunam, Y., 2017: KLHL6 Is Preferentially Expressed in Germinal Center-Derived B-Cell Lymphomas. KLHL6 is a recently described BTB-Kelch protein with selective expression in lymphoid tissues and is most strongly expressed in germinal center B cells. Using gene expression profiling as well as immunohistochemistry with an anti-KLHL6 monoclonal...

Uțu, D.; Pantea, S.; Duicu, O.M.; Muntean, D.M.; Sturza, A., 2017: Contribution of monoamine oxidases to vascular oxidative stress in patients with end-stage renal disease requiring hemodialysis. Arteriovenous fistula (AVF) is the "lifeline" for patients with end-stage renal disease (ESRD) undergoing hemodialysis. AVF maturation failure is a poorly understood process, one of the contributors being endothelial dysfunction due to o...

Patai, K.; Sipos, M.; Szarvas, Z.; Csomor, S.Jr.; Toth, P., 1998: Combination of ultrasound and vacuum aspiration in diagnosing premalignant endometrial changes. FASEB Journal 12(4): A476, March 17

Micu, G.; Stăniceanu, F.; Zurac, S.; Grămadă, E.; Bastian, A.; Tudose, I.; Mateescu, B.R.; Voiosu, R., 2011: Helicobacter pylori: pathological mechanism involved in gastric colonization. Since 1982, when Marshall and Warren highlighted the presence of H. pylori at the apical pole of the epithelial gastric cells, the medical literature has registered a cascade of subsequent researches concerning this amazing bacterium, its action o...

Romanova M.A., 1957: O vozraste magmaticheskikh porod okrestnostei g. Krasnovodska. A study of the mineral and chemical composition of the rocks, as well as the composition of the included feldspars, indicates that the magmatic rocks of the Krasnovodsk region, USSR, represent a single evolutionary series, ranging from more acidic...

Haines, R.Wheeler, 1935: Some muscular changes in the tail and thigh of reptiles and mammals. New dissections of the caudal and short posterior thigh muscles of the reptiles Iguana, Varanus, Crocodilus and Testudo, and the mammals Sciurus, Galago and Herpestes were made, and the findings correlated with those descr. in the literature. The...

Olivo, R.; Bugiardini, G., 1955: Widal reaction performed with antibiotic treated antigen. Bollettino Dell'istituto Sieroterapico Milanese 34(1-2): 80-90

Zaĭdes, V.M.; Zhdanov, V.M., 1984: Hemagglutination inhibition reaction as an indicator of humoral immunity in influenza: limitations of the method. Voprosy Virusologii 29(1): 4-8