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Enantioselective Friedel-Crafts reaction of indoles with arylidene malonates catalyzed by iPr-bisoxazoline-Cu(OTf)2


, : Enantioselective Friedel-Crafts reaction of indoles with arylidene malonates catalyzed by iPr-bisoxazoline-Cu(OTf)2. Chemical Communications: 432-433

The cheap and simple (i)Pr-bisoxazoline-Cu(OTf)(2) proves to be an efficient catalyst in the asymmetric Friedel-Crafts reaction of indole with arylidene malonates. In (i)BuOH, the S-enantiomer was obtained in up to 97% ee, while the opposite enantiomer was obtained in up to 78% ee in CH(2)Cl(2) or TTCE.

US$19.90

PMID: 14765244

DOI: 10.1039/b313197a


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