+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Estimation of pharmacokinetic parameters based on the patient-adjusted population data

, : Estimation of pharmacokinetic parameters based on the patient-adjusted population data. American Journal of Pharmaceutical Education 70(5): 96-96

Population pharmacokinetic data, adjusted for patient characteristics, are recommended for the design of initial dosage regimens of some therapeutically monitored drugs in patients for whom patient-specific data are not available. However, despite widespread use by clinicians such as pharmacists, a clear understanding of the principles of population pharmacokinetics, including data collection and analysis and its limitations, is often lacking. This article describes the 2 main methods of obtaining population kinetic data, namely the two-stage method and nonlinear mixed effect model, and their applications to the pharmacokinetic-based design of dosage regimens. Additionally, some numerical examples are provided to assist the reader in understanding the material. The author uses these tools in a pharmacokinetics course taught to PharmD students.


PMID: 17149425

Other references

Zilch, H.; Klemm, G.; Winter, T., 1986: Modification of bone regeneration by collagen fleece with and without addition of antibiotics. Der Unfallchirurg 89(10): 484-490

Gong, Q-Yao.; Chen, Y., 2016: Correlation between P2X7 receptor gene polymorphisms and gout. Not all patients with hyperuricemia will develop acute gouty arthritis, indicating that other initiating factors need to be considered. The P2X7 receptor is an adenosine triphosphate-gated nonselective cation channel that has also been suggested t...

Reutter K.J.; Teichmuller M.; Teichmuller R.; Zanzucchi Giorgio, 1981: Studies on the carbonification of vegetal fragments in clastic rocks in relation to a contribution to paleogeothermal and tectonic problems in the Northern Apennines. Memorie della Societa Geologica Italiana 21: 111-126

Tenenbein, M., 1987: Severe toxic reactions and death following the ingestion of diethyltoluamide-containing insect repellents. N,N-diethyl-m-toluamide (DEET) is the most commonly used mosquito repellent. This report describes five cases of toxic reactions after ingestion of insect repellents containing DEET. Each patient ingested large amounts of concentrated (47.5% to 95...

Arvystas, M.G., 1976: Familial generalized delayed eruption of the dentition with short stature. 1. Prolonged retention of the deciduous dentition, subsequent delay in eruption of the permanent dentition, and retardation in dental maturation are displayed outside the limits of normal variation. 2. The pedigree study of this family reveals the...

DiTomaso, J.M.; Miller, J.R.; Kyser, G.B.; Hazebrook, A.W.; Trumbo, J.; Valcore, D.; Carrithers, V.F., 2004: Aerial application of clopyralid demonstrates little drift potential and low toxicity to toads. The herbicide clopyralid (Transline) is commonly applied by air to control yellow starthistle (Centaurea solstitialis), a noxious weed, in California, USA. In laboratory studies, clopyralid toxicity in Fowler's toad was low, indicating a wide...

Kofman, E.B., 1963: Change in the state of Ag-titrable sulphydryl groups in actomyosin gel in syneresis. SH -groups content was assayed in natural actomyosin gel by amperometric silver titration. The gel was studied after a single precipitation as well as after additional washing or re-precipitation or after syneresis caused by ATP or thermal denatur...

Kowalski, W., 1968: Congenital short esophagus. Polski Przeglad Radiologii i Medycyny Nuklearnej 32(6): 729-733

Palumbiny, C.M.; Liu, F.; Russell, T.P.; Hexemer, A.; Wang, C.; Müller-Buschbaum, P., 2015: The Crystallization of PEDOT:PSS Polymeric Electrodes Probed In Situ during Printing. Advanced Materials 27(22): 3391-3397

Dinour, L.M.; Beharie, N., 2015: Lessons Learned from a Student-Led Breastfeeding Support Initiative at a US Urban Public University. Despite US laws requiring most workplaces to provide "reasonable" unpaid break time and a private space for female employees to express breast milk, much of the statutory language is vague and open to interpretation, potentially leading...