geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Evidence of recurrent gene fusions in common epithelial tumors


, : Evidence of recurrent gene fusions in common epithelial tumors. Trends in Molecular Medicine 12(11): 529-536

Chromosomal aberrations that accompany carcinogenesis have been documented for almost half a century, with gene fusions being the most prevalent type of aberration. Gene fusions leading to generation of aberrant fusion proteins or aberrant expression of normal proteins are a potent route to carcinogenesis and have recently emerged as attractive therapeutic targets. Intriguingly, although gene fusions have been widely observed in hematological malignancies, they have been far less frequently described in the more-common epithelial carcinomas. It has been recently proposed that technical issues, rather than any fundamental dichotomy between hematological and solid cancers, account for the under-representation of gene fusions in epithelial cancers. Recent reports from our group support this contention and provide evidence of widespread recurrent gene fusions in prostate cancer using a novel analysis of gene-expression profiles. Here, we provide an appraisal of the state of the knowledge of gene fusions in epithelial cancers. Future implications of gene fusions in common epithelial cancers are also discussed.

US$19.90

PMID: 17011825

DOI: 10.1016/j.molmed.2006.09.005


Other references

SIDERAITE.S.A.; KIBARKIS.K.Kh., 1964: Apropos Of Clinical And Therapeutic Aspects Of Myocardial Infarction In Diabetic Patients. Problemy Endokrinologii i Gormonoterapii 10: 10-13

Wetzel D.L.; Ernst T.A.; Arndt E.A., 1988: Nir determination of germ distribution in wheat milling fractions. Cereal Foods World 33(8): 698

Fujimoto; Kawakami, 1995: Exact finite-size spectrum for the multi-channel Kondo model and Kac-Moody fusion rules. Physical Review. B, Condensed Matter 52(18): 13102-13105

Simon, J.A., 2012: Identifying and treating sexual dysfunction in postmenopausal women: the role of estrogen. Sexual dysfunction is a common, but frequently overlooked, problem in postmenopausal women. At menopause, dramatic decreases in circulating estrogen concentrations cause physiologic changes that may affect sexual function, most notably the develop...

Goudard, A.; Loreau, M., 2008: Nontrophic interactions, biodiversity, and ecosystem functioning: an interaction web model. Research into the relationship between biodiversity and ecosystem functioning has mainly focused on the effects of species diversity on ecosystem properties in plant communities and, more recently, in food webs. Although there is growing recogniti...

McMurray, A.R., 1994: Three decision-making aids: brainstorming, nominal group, and Delphi technique. The methods of brainstorming, Nominal Group Technique, and the Delphi technique can be important resources for nursing staff development educators who wish to expand their decision-making skills. Staff development educators may find opportunities...

Ballesteros, L.; Guardia, M. de la; Vicente, E., 1988: The presence of nitrate in the waters of the ecosystem of the Albufera de Valencia. The distribution of nitrate was studied in the vicinity of the lake 'Albufera de Valencia'. In the April-September 1986 period, levels <40 ppm were recorded for the lake water, irrigation channels and in rice fields about them; levels...

Yashouv, A., 1960: Effect of low temperatures on Tilapia nilotica and Tilapia galilaea. Tilapia are near their northern limit of distribution in Israel, and hence are subject to occasional winter kills. Laboratory experiments showed that both Tilapia nilotica and T. galilaea could survive water temperatures as low as 7[degree]C if no...

Yen,C.Y.T.; Starman,T.W.; Wang,Y.T.; Niu,G.H., 2008: Effects of cooling temperature and duration on flowering of the nobile dendrobium orchid. The effects of cooling temperature [constant (10, 13, 15, or 18 degrees C, or 15, 18, or 21 degrees C)] and duration (2, 3, 4, 5, or 6 weeks, or 3, 4, 5, 6, or 7 weeks) at two separate locations (College Station and Weslaco, TX) on growth and flow...

Brayboy, L.M.; Oulhen, N.; Long, S.; Voigt, N.; Raker, C.; Wessel, G.M., 2017: Multidrug resistance transporter-1 and breast cancer resistance protein protect against ovarian toxicity, and are essential in ovarian physiology. Ovarian protection from chemotoxicity is essential for reproductive health. Our objective is to determine the role of ATP-dependent, Multidrug Resistance Transporters (MDRs) in this protection. Previously we identified MDR-dependent cytoprotection...