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Extent of hepatectomy on splenic hypertrophy and platelet count in live liver donors

, : Extent of hepatectomy on splenic hypertrophy and platelet count in live liver donors. Clinical Transplantation 20(2): 234-238

The extent of donor hepatectomy may affect splenic hypertrophy and platelet count. The subjects were 50 live liver donors. The ratio of the graft weight to total liver volume (GW/TLV) and the splenic hypertrophy ratio, expressed as the splenic volume one month after surgery divided by that before surgery, were calculated. The platelet count one month after surgery was divided by that before surgery to determine the rate of the platelet count decrease. The correlation of GW/TLV to the splenic hypertrophy ratio and the rate of the platelet count decrease were examined. The median (range) GW/TLV was 54 (28-71)%. The splenic hypertrophy ratio and the rate of the platelet count decrease was 133 (99-191)% and 92 (71-129)%, respectively. GW/TLV positively correlated with the splenic hypertrophy ratio (Spearman's correlation coefficient (r(s)) = 0.448, p = 0.001), and negatively correlated with the rate of the platelet count decrease (r(s) = -0.471, p < 0.001). Multivariate analysis revealed that GW/TLV influenced the splenic hypertrophy ratio [adjusted odds ratio (OR), 12.0; 95% confidence interval (CI), 1.32-9.04; p = 0.01] and the ratio of the platelet count decrease (adjusted OR, 11.6; 95% CI, 1.40-8.33; p = 0.01). Larger graft procurement might place living liver donors at higher risk for post-operative thrombocytopenia.


PMID: 16640532

DOI: 10.1111/j.1399-0012.2005.00474.x

Other references

Becker, A.J.; Ueckert, S.; Stief, C.G.; Truss, M.C.; Machtens, S.; Scheller, F.; Knapp, W.H.; Hartmann, U.; Jonas, U., 2000: Possible role of human growth hormone in penile erection. Purpose: Treatment with recombinant human growth hormone in adult patients with growth hormone deficiency increases nitric oxide and cyclic guanosine monophosphate (cGMP). We examined the functional in vitro effects of recombinant human growth hor...

Heller R.F.; Delvalle J.R.; Kleinerman J.; Gordon R.E., 1989: Morphometric analyses of morphologic changes in hamster epithelium responding to long term intermittent nitrogen dioxide exposure followed by long term non exposure to nitrogen dioxide. American Review of Respiratory Disease 139(4 PART 2): A123

Tammilehto, S.; Büchi, J., 1969: Studies on para-hydroxybenzoic acid ester (Nipagine). 2. Detection, purity test and determination with 4-aminoantipyrine. Pharmaceutica Acta Helvetiae 44(3): 138-148

Bamforth, C.W.; Large, P.J., 1977: Solubilization, partial purification and properties of N-methylglutamate dehydrogenase from Pseudomonas aminovorans. 1. Extracts of amine-grown Pseudomonas aminovorans contained a particle-bound N-methylglutamate dehydrogenase (EC The enzyme was not present in succinate-grown cells, and activity appeared before growth began in succinate-grown cells wh...

Supakul, N.; Loder, R.T.; Karmazyn, B., 2013: Dynamic US study in the evaluation of infants with vertical or oblique talus deformities. Congenital vertical talus (CVT) is a rare foot deformity that is sometimes difficult to differentiate from oblique talus (OT) by physical examination and foot radiography. The purpose of this study was to summarize our experience with US in evalua...

Morin-Papunen, L.; Martikainen, H.; McCarthy, M.I.; Franks, S.; Sovio, U.; Hartikainen, A-Liisa.; Ruokonen, A.; Leinonen, M.; Laitinen, J.; Järvelin, M-Riitta.; Pouta, A., 2008: Comparison of metabolic and inflammatory outcomes in women who used oral contraceptives and the levonorgestrel-releasing intrauterine device in a general population. We compared the metabolic and cardiovascular parameters of a reference group of women with those of women who used 2 contraceptive regimes that are used worldwide: the levonorgestrel-releasing intrauterine device and oral contraceptives. We invest...

Storch W., 1982: Immuno histochemical demonstration of the complement c 4 in bile thrombi and liver cells in pseudoglandular transformation of hepatocytes. The immunohistochemical demonstration of complement component C4 in a case of pseudoglandular transformation of liver cells probably caused by viral hepatitis is described. C4 could be found in the lumen of dilated bile canaliculi in a position wi...

Greenplate, J.T.; Mullins, J.W.; Penn, S.R.; Dahm, A.; Reich, B.J.; Osborn, J.A.; Rahn, P.R.; Ruschke, L.; Shappley, Z.W., 2003: Partial characterization of cotton plants expressing two toxin proteins from Bacillus thuringiensis: Relative toxin contribution, toxin interaction, and resistance management. Laboratory studies were performed to characterize the lepidopteran toxicity of cotton plants expressing two different toxin proteins from Bacillus thuringiensis (Bt), in order to assess insect resistance management implications of a commercial, tw...

Voaden M.J.; Marshall J.; Murani N., 1974: The uptake of tritiated gamma amino butyric acid and tritiated glycine by the isolated retina of the frog. Brain Research 67(1): 115-132

Engle, R.W.; Tuholski, S.W.; Laughlin, J.E.; Conway, A.R.A., 1999: Working memory, short-term memory, and general fluid intelligence: A latent-variable approach. A study was conducted in which 133 participants performed 11 memory tasks (some thought to reflect working memory and some thought to reflect short-term memory), 2 tests of general fluid intelligence, and the Verbal and Quantitative Scholastic Apt...