+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Familiality in simple and complex disease

, : Familiality in simple and complex disease. Clinical Autonomic Research 13(2): 88-90

Establishing the existence of a genetic contribution to disease is the first step in identifying the underlying gene defect(s). This can present a considerable challenge, particularly in diseases where the genetic contribution is complex in nature. Clinically well-characterized cohorts and large inter-institutional collaborations will be required to identify genes involved in complex disease.


PMID: 12720091

DOI: 10.1007/s10286-003-0091-9

Other references

Woolley, Ta, 1973: Taxonomy of oribatid mites-retrospect and prospect. International Congress of Acarology 3d Prague 1971 Proceedings: 37-341

Yamanaka, T.; Chiba, S.; Nakao, T.; Okabe, N.; Takahashi, N., 1977: Cell-mediated immunity to measles virus in subacute sclerosing panencephalitis. Four patients with subacute sclerosing panencephalitis were investigated for their specific cellular and humoral immunities against measles virus. Lymphocytotoxicity mediated by peripheral blood lymphocytes was evaluated with the colony inhibition...

Baier, W., 1979: Crop weather models: concepts and applications. Satellite Remote Sensing Applications in Agroclimatology and Agrometeorology: proceedings of an International Training Course organized by the European Space Agency the Food and Agriculture Organization of the United Nations and the World Meteorological Organization held in Rome Italy 2-13 October 1978: 3

Munteanu, A.; Cute, E.; Godeanu, S.; Eminovici, A.; Murgoci, C., 1967: Treatment of wastewaters from synthetic rubber industry. The tests and investigations carried out at this treatment plant provided data which suggest several design modifications and completions. Effluents from synthetic rubber industries can be submitted to a primary and biological treatment without ad...

Conrad, D.J.; Warnock, M.; Blanc, P.; Cowan, M.; Golden, J.A., 1992: Microgranulomatous aspergillosis after shoveling wood chips: report of a fatal outcome in a patient with chronic granulomatous disease. Chronic granulomatous disease is characterized by recurrent infections that result from an inability of phagocytes to kill organisms effectively. We describe a patient with this disease who developed aspergillus pneumonia after shoveling moldly ce...

Fischer, W.A.tsberg, G.S.hal, M., 1983: Investigations on the therapeutic effect of a gentamicin formulation and symptomatic antidiarrhoeal preparation on Escherichia coli infections in calves. Tierarztliche Umschau, 38(6): 394

Zhou, J-Lie.; Mao, X-Xia.; Gu, J-Fan., 2012: Update on reassessment of dietary reference intakes (DRIs) for vitamin D. The latest clinical studies show that vitamin D has many health promoting functions. However, the current dietary reference intakes (DRIs) of vitamin D is too low. In particular the maximum tolerable intake (UL) of vitamin D is too low, which hamp...

Burkens, J.C.J., 1951: A case of PAS poisoning with hemolysis. Nederlands Tijdschrift Voor Geneeskunde 95(50): 3788-3790

Ichimura H.; Yamaki T., 1975: Iaa in chick embryos. Development Growth & Differentiation 17(3): 275-279

Kasi, S.; Immonen, J.; Saikku, K., 1983: Some considerations for soil moisture gauging with neutrons. The following are discussed: (a) sensitivity of the moisture gauge, (b) calibration, (c) interfering elements, and (d) sphere of influence.