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Functional genomics and its impact on the future medicine

, : Functional genomics and its impact on the future medicine. Polski Merkuriusz Lekarski 16(93): 205-207

The sequencing of the human genome was completed in 2003. These data will affect all aspects of biological and medical sciences. Since almost all the genes of the genome are known, the diagnosis and therapy of the future is expected to evolve towards more personalized and efficient methods. Before these medical advancements become applicable, functional genomics must successfully determine the cellular role all the genes in the genome. Comprehensive functional studies will require suitable animal models. Although many mammalian species are used in biological and medical experiments, the mouse emerges as a key model organism in studies of human genes. The power of the mouse model system comes from its extensive physiological and pathological similarities to humans and from technological advancements offered by mouse genetics. Recently, a project called ENCODE was launched to accelerate this monumental effort of gene analysis. Once gene analysis is completed, the face of medicine will change markedly. The greatest impact is expected on the front of individual diagnosis of disease genes and personalized treatments of patients.


PMID: 15190590

Other references

Amano, N., 1987: Effects of anesthesia and various types of stress on prostaglandin D2 (PGD2) contents in brain and plasma levels of stress hormones in rats. Masui. Japanese Journal of Anesthesiology 36(9): 1374-1382

Chaĭchenko, H.M., 1975: The effect of total x-irradiation on the lability of nervous processes in young rats. Fiziolohichnyi Zhurnal 21(3): 337-342

Matsumoto, N.; Arase, Y.; Seko, Y.; Imai, N.; Kawamura, Y.; Sezaki, H.; Hosaka, T.; Akuta, N.; Kobayashi, M.; Kobayashi, M.; Suzuki, Y.; Saito, S.; Suzuki, F.; Ikeda, K.; Kumada, H.; Aida, K.; Kobayashi, T., 2012: Prevalence and predictive factors of diabetes in hepatitis virus positive liver cirrhosis with fasting plasma glucose level of <126 mg/dL.   The aim of this study was to evaluate the prevalence and predictive factors of diabetes in hepatitis virus positive liver cirrhotic patients with fasting plasma glucose (FPG) level of <126 mg/dL.   A total of 263 patients with hepatitis...

Preisig C.L.; Vanetten H.D.; Moreau R.A., 1991: Biosynthesis of the phytoalexin pisatin studies with antisera against the 6a hydroxymaackiain 3 o methyltransferase. Journal of Cellular Biochemistry Supplement (15 PART A): 60

Rollings, M.; Stone, O.M.; Smith, D.R., 1972: Productivity of virus-tested Carnation clones and the rate of re-infection with virus. During 82 weeks' cropping 6 of 7 cvs. derived from meristem tips, indexed for freedom from viruses and planted at 6X61/2 in, yielded over 100 flowers/ft2; flower quality and colour were excellent. No virus was detected after 10 months but aft...

Christensen, Roland J., 2001: Prosthetic foot simulating toe rotation. A prosthetic foot, having a forefoot member and a heel member, is comprised of two separate members forming opposite halves of the foot generally about the longitudinal axis of the foot for simulating natural rotation of the toes of a real foot. T...

Frey, J.J., 1987: Three generations building on history. Family Medicine 19(4): 249-250

Nesje, O.A.; Enge, I., 1979: Impaired rate of left ventricular filling in idiopathic hypertrophic subaortic stenosis with atrial fibrillation. The external carotid pulse and the phonocardiogram were recorded in a 48-year-old man with idiopathic hypertrophic subaortic stenosis and atrial fibrillation. The degree of obstruction of left ventricular outflow was assessed by the depth of the m...

Franklin, J.A., 1987: The changing nature of agoraphobic fears. Recent factor analytic studies have emphasized the importance of both somatic and situational fears in agoraphobia. Franklin (1980) proposed a developmental model of agoraphobic fears in which somatic changes (interoceptive fears), and feared cons...

Daly, J.W.; Myers, C.W.; Warnick, J.E.; Albuquerque, E.X., 1980: Levels of batrachotoxin and lack of sensitivity to its action in poison-dart frogs (Phyllobates). Batrachotoxin is present in remarkably high amounts in the skin of Phyllobates terribilis. Levels of batrachotoxin tend to be reduced when P. terribilis is maintained in captivity, but even after being confined for up to 6 years, these frogs were...