+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Gallbladder carcinoma: a retrospective analysis of twenty-two years experience of a single teaching hospital

, : Gallbladder carcinoma: a retrospective analysis of twenty-two years experience of a single teaching hospital. International Seminars in Surgical Oncology 2(1): 6-6

BACKGROUND: The purpose of this study was to retrospectively evaluate our experience with gallbladder cancer since the establishment of a tumour registry in our institute. METHODS: Between 1975 and 1998, 23 consecutive patients with gallbladder cancer were identified using the tumour registry database. There were 18 females (78%) and 5 (22%) males. The mean age at diagnosis was 70.6 (range 42-85) years. The diagnosis was achieved either intra-operatively or following the histological analysis of the gallbladder (n = 17), following gallbladder or liver biopsy (n = 4) or at autopsy (n = 2). Presenting symptoms included upper abdominal pain, weight loss, nausea, vomiting, fever, painless jaundice, hepatomegaly, upper abdominal mass, upper abdominal tenderness, and gastrointestinal haemorrhage. RESULTS: Histological examination revealed 20 adenocarcinomas (87%), 2 squamous cell carcinomas (9%) and one spindle cell sarcoma (4%). At presentation, 14 (61%) gallbladder cancers were stage IV, 5 (22%) were stage III and 4 (17%) were stage II. Kaplan Meier analysis revealed a mean survival of 3.2, 7.8 and 8.2 months for stage IV, III, and II disease respectively. Out of 14 patients with stage IV disease, 8 patients received adjuvant chemotherapy and survived for 4.6 months whereas six patients who did not receive adjuvant chemotherapy survived for 1.3 months. This difference was statistically significant (p = 0.04). CONCLUSION: The majority of patients with gallbladder cancer presented with advanced stage disease (stage IV) which carries a dismal prognosis. Patients who received chemotherapy with stage IV disease, however, did better than those who did not, but this is probably a reflection of patient selection.


PMID: 15774016

DOI: 10.1186/1477-7800-2-6

Other references

Nemes, A.; Forster, Tás.; Csanády, Mós., 2006: Impaired coronary flow velocity reserve and aortic distensibility in patients with untreated hypercholesterolemia--an echocardiographic study. Hypercholesterolemia is a primary risk factor for the development of atherosclerosis and leading to severe stages of coronary artery disease (CAD) and aortic atherosclerosis (AA). The objective of this investigation was to measure elastic modulus...

Fau D.; Delhomme B.; Bourdon D.; Rerat A., 1980: Hepatic enzyme activities and muscle nucleic acid content in swine fed a diet imbalanced by methionine excess for 100 days. Twelve growing swine were fed an 18% protein diet (maize and soybean) for 100 days containing 0.6% S amino acids (basal diet), or 0.6 and 1% DL-methionine added to the control diet. The excess reduced food intake and body wt gain mainly during the...

Szakszon, K.; Berényi, E.; Jakab, Aás.; Bessenyei, Báta.; Balogh, Eébet.; Köbling, Tás.; Szilvássy, J.; Knegt, A.C.; Oláh, E., 2011: Blepharophimosis mental retardation syndrome Say-Barber/Biesecker/Young-Simpson type - new findings with neuroimaging. We report on a female patient with blepharophimosis mental retardation syndrome of Say/Barber/Biesecker/Young-Simpson (SBBYS) type. Main findings in her were marked developmental delay, blepharophimosis, ptosis, cleft palate, external auditory can...

Parsons, W.B., 1927: Adenoma Of The Thyroid. Annals of Surgery 85(1): 107-115

Carroll, P., 1980: Wiry skeletonweed threatens Oregon agriculture, rangelands. Skeletonweed (Chondrilla juncea), a tough Mediterranean native, has infested large areas in Australia and the northwestern USA. Skeletonweed invades both cultivated and grazing lands resulting in severe economic loss. Government agencies have comb...

Caporiacco, Ldi., 1947: Arachnida Africae orientalis, a dominibus Kittenberger, Kovacs et Bornemisza lecta, in Museo Nationali Hungarico servata. Annales Historico Naturales Musei Nationalis Hungarici, 403: 97-257

Lima,; Barbosa, W.Lins.; Brito,; Melo, Fá; Brandão, S.Pinto.; Medeiros,, 2017: Characterization of Leishmania (L.) infantum chagasi in visceral leishmaniasis associated with hiv co-infection in Northeastern Brazil. Visceral leishmaniasis, associated with HIV/AIDS coinfection, is becoming a more aggressive disease, complicating an accurate prognosis. A 21-year-old HIV-positive female presenting with clinical features of visceral leishmaniasis was enrolled in...

Koch, E., 1983: Pelecyphora aselliformis Ehre. Kakteen und andere Sukkulenten 34(6): 140

Badonnel, A., 1931: Contribution a letude de la faune du Mozambique Voyage de M P Lesne 4e note. A record of 19 spp. Caeciliidae: Pseudocaecilius elutus v. africanus [female] (p. 230) ; Caecilius glossopterus [female]* (p. 230) ; C. p'sicensis [female]* (p. 232) ; C. casarum [female]* (p. 234) ; PARACAECILIUS (p. 235), near Caecilius, ty...

Aleman, Aé.; David, A.S., 2006: How to fill a half-full glass: emotion and schizophrenia. American Psychologist 61(1): 75-76