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Gemcitabine therapy in patients with advanced pancreatic cancer

, : Gemcitabine therapy in patients with advanced pancreatic cancer. Korean Journal of Internal Medicine 17(4): 259-262

Advanced, unresectable pancreatic cancer is an extremely aggressive disease. The 5-year survival rate for pancreatic cancer is only less than 5%. Current therapeutic options for patients with locally advanced or metastatic disease are limited. This analysis is a retrospective evaluation of the efficacy and toxicity of gemcitabine regimen as first-line chemotherapy in patients with advanced pancreatic cancer. Seventeen chemotherapy-naive patients with advanced or recurred pancreatic cancer were consecutively treated. Gemcitabine was diluted in normal saline and administered intravenously over 1 hour. Gemcitabine 1,000 mg/m2 was administered once weekly for 3 out of every 4 weeks. The median age of patients was 55 years (range 44-82 years). Based on RECIST criteria, there were 5 cases of stable disease (45%) and 6 cases of progressive disease (55%) among the 11 assessable patients. The median survival time was 189 days (range, 84 to 409 days), the 1 year survival rate was 18% in all 17 patients. Grade 3-4 toxic side effect was leucopenia only (29%) and was easily managed without infection. Gemcitabine is well tolerated, but has no objective response in advanced pancreatic cancer.


PMID: 12647642

Other references

Andrievskaya Z.M.; Mel'nikov O.R.; Sidorik E.P., 1984: Electron carriers of the pulmonary and hepatic detoxifying system in chemical carcinogenesis under conditions of modifying action of influenza virus. Electron carriers of the pulmonary and hepatic detoxifying system were first studied under conditions of a combined effect of polycyclic aromatic hydrocarbons and influenza A virus. The state of the detoxifying system was determined by recording t...

Walton, J.; Ahn, J.; Akimitsu, K.P.tkin, J., 1994: Leaf-spot disease of maize: chemistry, biochemistry, and molecular biology of a host-selective cyclic peptide. Current plant science and biotechnology in agriculture1(21): 231-237

Fowle D.A.; Fein J.B.; Kemner K.M.; Bunker B.A.; Kelly S.; Boyanov M., 1999: Copper biomineralization; toward quantifying the effects of bacteria on precipitation. LPI Contribution: 88-89. 1999.

Henriet, J.P., 1987: Value of sclerotherapy in the treatment of certain types of impotence caused by venous leakage. Certain types of impotence, primary or secondary, are due to an "escape" through the superficial venous network of the penis, connecting distally with the femoral veins. Until now, the treatment was surgical and marred with recurrences....

Petek, M.-Rafael; Sera, T.; De-Batista-Fonseca, I.-Cristina, 2008: Predicao de valores geneticos aditivos na selecao visando obter cultivares de cafe mais resistentes a ferrugem. The aim of this research was to estimate genetic parameters and predict the additive genetic values in the selection of Coffea arabica progenies ("Sarchimor" x ("Icatu" x "Catuai")) carrying more than five rust resis...

Critchlow, J.D.; Matson, P.L.; Killick, S.; Lieberman, B.A., 1992: Pregnancy following intravaginal embryo transportation. British Journal of Obstetrics and Gynaecology 99(3): 259-260

Olivera A.A.; Arrascue W., 1971: Quinoa flour proteins part 2 electrophoretic patterns of different preparations effect of urea. Boletin de la Sociedad Quimica del Peru 37(2): 66-67

Reynolds, L.B.; Potter, J.W.; Ball Coelho, B.R., 2000: Crop rotation with Tagetes sp. is an alternative to chemical fumigation for control of root-lesion nematodes. The root-lesion nematode (Pratylenchus penetrans Cobb) is a significant pest of many crops in Ontario. For example, more than 25000 ha of land cropped to flue-cured tobacco (Nicotiana tabacum L.) is fumigated annually at a mean cost for the fumiga...

Grant, O.; Lich, R., 1947: Rationale and results in retropubic prostatectomy. Transactions of the Southern Surgical Association. Southern Surgical Association 59: 174-185

Ogner, G., 1980: Analysis of the carbohydrates of fulvic and humic acids as their partially methylated alditol acetates. The carbohydrates of humic and fulvic acids were investigated using methylation analysis. The humic acid contains slightly more rhamnose and fucose than does fulvic acid and raw humus, the arabinose content of fulvic acid is less than that of humi...