+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Harvesting the fruit of the human mtDNA tree

, : Harvesting the fruit of the human mtDNA tree. Trends in Genetics 22(6): 339-345

Human mitochondrial DNA (mtDNA) studies have entered a new phase since the blossoming of complete genome analyses. Sequencing complete mtDNAs is more expensive and more labour intensive than restriction analysis or simply sequencing the control region of the molecule. But the efforts are paying off, as the phylogenetic resolution of the mtDNA tree has been greatly improved, and, in turn, phylogeographic interpretations can be given correspondingly greater precision in terms of the timing and direction of human dispersals. Therefore, despite mtDNA being only a fraction of our total genome, the deciphering of its evolution is profoundly changing our perception about how modern humans spread across our planet. Here we illustrate the phylogeographic approach with two case studies: the initial dispersal out of Africa, and the colonization of Europe.


PMID: 16678300

DOI: 10.1016/j.tig.2006.04.001

Other references

Goodman, M.J.; Brixner, D.I., 2013: New therapies for treating Down syndrome require quality of life measurement. Down syndrome (DS) is the most common genetic cause of cognitive deficits. Using mouse models and therapies for Alzheimer disease, researchers are exploring therapies that may improve cognitive function in people with DS. These developments shift...

Johnson, MS., 1975: Biochemical systematics of the atherinid genus menidia. Copeia, 4: 662 .691

Cairns, F.J.; Herdson, P.B.; Hitchcock, G.C.; Koelmeyer, T.D.; Smeeton, W.M.; Synek, B.J., 1981: Aircrash on Mount Erebus. Medicine, Science, and the Law 21(3): 184-188

Nasir Mahmood Nasir; Riaz Hussain Qureshi; Muhammad Aslam, 2000: Effect of salinity on emergence of sugarcane lines. Salinity decreases plant growth and yield to various degrees depending upon plant species but seed emergence is generally the most sensitive stage. In most cases, screening of crops at emergence is necessary because high yield depends upon a good...

Vasudevan, S.; Chen, G.Chung.Kit.; Andika, M.; Agarwal, S.; Chen, P.; Olivo, M., 2011: Dynamic quantitative photothermal monitoring of cell death of individual human red blood cells upon glucose depletion. Red blood cells (RBCs) have been found to undergo "programmed cell death," or eryptosis, and understanding this process can provide more information about apoptosis of nucleated cells. Photothermal (PT) response, a label-free phototherma...

Simon, S.M.; Waters, L.S.; Jarosz, D.F.; Beuning, P.J., 2009: Song: SOS (To the Tune of ABBA's "SOS"). Biochemistry and Molecular Biology Education 37(5): 316-316

Reijonen, H.; Ilonen, J.; Knip, M.; Michelsen, B.; Akerblom, H.K., 1990: HLA-DQ beta-chain restriction fragment length polymorphism as a risk marker in type 1 (insulin-dependent) diabetes mellitus: a Finnish family study. Finnish Type 1 (insulin-dependent) diabetic families were analysed for HLA-DQ beta-chain polymorphism using a short intron-specific probe. A simple hybridization pattern was obtained in which all fragments were associated significantly with Type 1...

Pedersen, B.Ginnerup.; Moran, B.; Brown, G.; Blomqvist, L.; Fenger-Grøn, M.; Laurberg, Søren., 2012: Reproducibility of depth of extramural tumor spread and distance to circumferential resection margin at rectal MRI: enhancement of clinical guidelines for neoadjuvant therapy. The purpose of this study was to evaluate the reproducibility of measurements of minimal distance from an invasive tumor to the anticipated circumferential resection margin in prediction of depth of extramural tumor spread in patients with rectal...

Chung, C.P.; Oeser, A.; Raggi, P.; Solus, J.F.; Avalos, I.; Linton, M.F.; Fazio, S.; Stein, C.Michael., 2008: Lipoprotein subclasses and particle size determined by nuclear magnetic resonance spectroscopy in systemic lupus erythematosus. Patients with systemic lupus erythematosus (SLE) have accelerated atherosclerosis, but the underlying mechanisms are unclear. The size and number of lipoprotein particles may be better predictors of atherosclerosis than conventional cholesterol me...

Diu A.; Fevrier M.; Moreau J.L.; Gougeon M.L.; Theze J.; Reinherz E.L., 1988: Evidence for a human b cell activating factor acting on resting b lymphocytes. Mani, J C And J Dornand (Ed ) Lymphocyte Activation And Differentiation: Fundamental And Clinical Aspects; 18th International Leucocyte Culture Conference, La Grande Motte, France, June 19-24, 1987 Xxi+960p Walter De Gruyter And Co : Berlin, West Germany; Hawthorne, New York, Usa Illus 271-274