+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Health, 'small-worlds', fractals and complex networks: an emerging field

, : Health, 'small-worlds', fractals and complex networks: an emerging field. Medical Science Monitor 9(5): Mt19-Mt23

The importance of 'small-worlds', fractals and complex networks to medicine are discussed. The interrelationship between the concepts is highlighted. 'Small-worlds'--where large populations are linked at the level of the individual have considerable importance for understanding disease transmission. Complex networks where linkages are based on the concept 'the rich get richer' are fundamental in the medical sciences--from enzymatic interactions at the subcellular level to social interactions such as sexual liaisons. Mathematically 'the rich get richer' can be modeled as a power law. Fractal architecture and time sequences can also be modeled by power laws and are ubiquitous in nature with many important examples in medicine. The potential of fractal life support--the return of physiological time sequences to devices such as mechanical ventilators and cardiopulmonary bypass pumps--is presented in the context of a failing complex network. Experimental work suggests that using fractal time sequences improves support of failing organs. Medicine, as a science has much to gain by embracing the interrelated concepts of 'small-worlds', fractals and complex networks. By so doing, medicine will move from the historical reductionist approach toward a more holistic one.


PMID: 12761464

Other references

Martinović, D.; Radić, M.; Fabijanić, D.; Fabijanić, A., 2008: Antiphospholipid syndrome: from diagnosis to treatment. Antiphospholipid syndrome (APS) is a prothrombotic disorder mediate with characteristic antiphospholipide antibodies (aPL). Patients with APS have got higher risk for arterial or venous thromboembolism. However, in spite of numerous studies the tr...

Cavaliere, B.; Macchione, B.; Monteleone, M.; Naccarato, A.; Sindona, G.; Tagarelli, A., 2011: Sarcosine as a marker in prostate cancer progression: a rapid and simple method for its quantification in human urine by solid-phase microextraction-gas chromatography-triple quadrupole mass spectrometry. Sarcosine is an amino acid derivative of N-methylglycine and is involved in the amino acid metabolism and methylation processes that are enriched during prostate cancer progression. It could also serve as a new target to be measured during therape...

Herschman, A., 1989: Memo to members. Science 243(4891): 673-673

Tojima, T.; Akiyama, H.; Itofusa, R.; Li, Y.; Katayama, H.; Miyawaki, A.; Kamiguchi, H., 2006: Attractive axon guidance involves asymmetric membrane transport and exocytosis in the growth cone. Asymmetric elevation of the Ca(2+) concentration in the growth cone can mediate both attractive and repulsive axon guidance. Ca(2+) signals that are accompanied by Ca(2+)-induced Ca(2+) release (CICR) trigger attraction, whereas Ca(2+) signals tha...

Bannister, CW., 1975: Distinguished visitor to Ashchurch Depot. Journal N Gloucs Nat Soc, 2611: 132-133

Hou, X.-xian.; Dong, W.-hua.; Yang, Y.-ping., 2003: Analysis on the population dynamics of desert hamster in Ordos sandland. Zhongguo Meijieshengwuxue Ji Kongzhi Zazhi. Jun; 143: 177-180

Brummett, Randall E., 1995: Environmental regulation of sexual maturation and reproduction in tilapia. Reviews in Fisheries Science, 33: 231-248

Skobkowski, E., 1966: Morphological and physiological characters of the Mazury horse population. A biometrical analysis was made of 335 brood mares. Although all subspecies were represented, the majority of the mares showed features characteristic of the subspecies Equus caballus muni-nensis and E. c. ewarti. Mares of the E. c. ewarti type li...

Scheer, K.E.; Winkel, K.Z.m; Taeger, F., 1962: The effects of radiotherapy on kidney functio. Since 1959 renal function tests with isotope nephrography were made in all patients with abdominal or retro-peritoneal tumor findings. A study of over 2000 cases showed an extraordinary frequency of distinct disturbances of the urinary tract, not...

Loike, J.D.; Kozler, V.F.; Silverstein, S.C., 1979: Increased ATP and creatine phosphate turnover in phagocytosing mouse peritoneal macrophages. Resident and thioglycollate-elicited macrophages maintained in culture for 24 h contain approximately 5 x 10(-16) and 12 x 10(-16) mol of ATP per cell, respectively. During particle ingestion, the levels of ATP in these cells did not change. Howev...