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Highly toxic coplanar PCBs: occurrence, source, persistency and toxic implications to wildlife and humans

, : Highly toxic coplanar PCBs: occurrence, source, persistency and toxic implications to wildlife and humans. Environmental Pollution 47(2): 147-163

Isomer-specific determinations of PCB congeners in a wide variety of animal species such as fish, marine mammals (whale, dolphin and porpoise) and terrestrial mammals (dog, cat and human) revealed the environmental occurrence of highly toxic coplanar 3,3',4,4'-tetrachlorobiphenyl (T(4)CB), 3,3',4,4',5-pentachlorobiphenyl (P(5)CB) and 3,3',4,4',5,5'-hexachlorobiphenyl (H(6)CB) within a range of few pg g(-1) to several ten ng g(-1) in fat tissues (except fish) on a wet weight basis. Detection of these toxic residues in wild specimens collected from remote areas such as the North Pacific suggests the already widespread distribution of coplanar PCBs as in the case of general PCB pollution. The clear positive correlations between concentrations of total PCBs and each of the three coplanar PCBs obtained in all mammals analysed suggest that the sources of coplanar PCB contamination to the environment are mainly commercial PCB preparations. Comparison of the composition of three toxic coplanar PCBs in commercial PCB mixtures and in the various animals indicates the relative metabolisability of these congeners as follows: 3,3',4,4'-T4CB>3,3',4,4',5-P5CB>3,3',4,4',5,5'-H6CB. Moreover, marine mammals seem to have lower potency to metabolise the coplanar PCBs in comparison with terrestrial mammals. In human adipose tissues, the concentrations of coplanar PCBs were found to be much higher than 2,3,7,8-tetrachlorodibenzo-p-dioxin (T(4)CDD), 2,3,4,7,8-pentachlorodibenzofuran (P(5)CDF) and other toxic congeners. 'T(4)CDD-equivalent' analysis based on the enzyme induction potencies and the residues of these toxic chemicals indicates that 3,3',4,4',5-P(5)CB may impose a greater toxic threat than dioxins and furans to the humans and probably to wildlife also.


PMID: 15092716

Other references

Anderson, M.; Lavoie-Tremblay, Mélanie., 2009: Evaluation of the Executive Training for Research Application (EXTRA) Program: Design and Early Findings. The authors of this paper describe the EXTRA Program, its intended outcomes, the approach they used to evaluate the program and some initial findings regarding the program's effects on the EXTRA fellows after the initial two-year period. The...

Gao, X.; Su, Y.; Zhao, W.; Qian, Q.; Chen, X.; Wittenbrink, R.; Wang, D., 2017: Unusual Interfacial Freezing Phenomena in Hexacontane/Silica Composites. The crystallization behaviors of n-hexacontane (C<sub>60</sub>H<sub>122</sub>)/Stöber silica (SiO<sub>2</sub>) composites with various compositions were investigated by a combination of differential scanning ca...

Dawber, T.R.; Kannel, W.B.; Revotskie, N.; Kagan, A., 1962: The epidemiology of coronary heart disease--the Framingham enquiry. Proceedings of the Royal Society of Medicine 55: 265-271

Briole P.; Massonnet D.; Delacourt C., 1997: Posteruptive deformation associated with the 1986-1987 and 1989 lava flows of Etna detected by radar interferometry. Geophysical Research Letters 24(1): 37-40

Sensabaugh, G.F.; Lincoln, P.J.; Olaisen, B., 2000: International Congress Series Progress in forensic genetics 8. Sensabaugh, George F , Lincoln, Patrick J , Olaisen, Bjornar International Congress Series Progress in forensic genetics 8 i-xxi, 1-635

Martin, S.R.; Schilstra, M.J., 2013: Rapid mixing kinetic techniques. Almost all of the elementary steps in a biochemical reaction scheme are either unimolecular or bimolecular processes that frequently occur on sub-second, often sub-millisecond, time scales. The traditional approach in kinetic studies is to mix two...

Spigliati, P.; Vannucchi, V., 1950: Mechanism of action of nitrogen mustard compounds; experimental study of the behavior of oxidase-peroxidase reactions in the leucocytes of peripheral blood. Minerva Medica 41(50): 679-684

Li, S.R.; Wu, K.K.; Anggard, E.; Ferns, G., 1993: Localization of prostaglandin G/H synthase gene expression in rat brain by in situ hybridization. Prostaglandin G/H synthase (PGH synthase; EC, cyclooxygenase) is a key enzyme in prostanoid biosynthesis. The cellular sites for PGH synthase gene expression have not been identified in any tissue. We have mapped the expression of PGH sy...

Maes, Martine, 1993: Fast classification of plant-associated bacteria in the Xanthomonas genus. A rapid method for identifying Xanthomonas bacteria was developed, based on specific PCR amplification. In all Xanthomonas pathovars tested, a single 16S rRNA fragment of 480 bp was produced. Phytobacteria from other genera showed other fragment p...

Ezeibe, M.C.O.; Ndip, E.T., 2004: Differences in the red blood cell elution times of strains of Newcastle disease virus. Elution times of velogenic, mesogenic and lentogenic strains of Newcastle disease virus were determined. Four samples each of velogenic (VGF2), mesogenic (Komarov) and lentogenic (Lasota) strains were used for haemaglutination test with 0.6% chick...