geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Humans as reservoir for enterotoxin gene--carrying Clostridium perfringens type A


, : Humans as reservoir for enterotoxin gene--carrying Clostridium perfringens type A. Emerging Infectious Diseases 12(11): 1724-1729

We found a prevalence of 18% for enterotoxin gene-carrying (cpe+) Clostridium perfringens in the feces of healthy food handlers by PCR and isolated the organism from 11 of 23 PCR-positive persons by using hydrophobic grid membrane filter-colony hybridization. Several different cpe genotypes were recovered. The prevalence was 3.7% for plasmidial IS1151-cpe, 2.9% for plasmidial IS1470-like-cpe, 0.7% for chromosomal IS1470-cpe, and 1.5% for unknown cpe genotype. Lateral spread of cpe between C. perfringens strains was evident because strains from the same person carried IS1470-like cpe but shared no genetic relatedness according to pulsed-field gel electrophoresis analysis. Our findings suggest that healthy humans serve as a rich reservoir for cpe+ C. perfringens type A and may play a role in the etiology of gastrointestinal diseases caused by this organism. The results also indicate that humans should be considered a risk factor for spread of C. perfringens type A food poisoning and that they are a possible source of contamination for C. perfringens type A food poisoning.

US$19.90

PMID: 17283623

DOI: 10.3201/eid1211.060478


Other references

Groom, T.M.; Gautieri, R.F., 1995: The effects of cicaprost and captopril on endothelium-dependent relaxation in hypercholesterolemic rabbits. Pharmaceutical Research (New York) 12(9 SUPPL ): S402

Zhou, J.; Menko, A.Sue., 2004: Coordinate signaling by Src and p38 kinases in the induction of cortical cataracts. PURPOSE. The goals of this study were to determine whether MAP kinase signaling pathways play a role in the formation of lens cataracts and to examine the potential signaling relationship between Src and MAP kinases in signaling the induction of l...

Devriese L.A.; Van D.K.rckhove A.; Kilpper Baelz R.; Schleifer K.H., 1987: Characterization and identification of enterococcus sp isolated from the intestines of animals. Tests useful for the identification of Enterococcus strains were applied to a collection of isolates from animal intestines and to reference strains, all of which were capable of growth on 40% bile and in 6.5% NaCl. Most strains could be identifie...

Burkart, J.M.; Beaubrun, A.C.; Olson, K.A.; Park, G.S.; Yue, S.V.; Rubin, R.J., 2016: Anemia management practice patterns in small dialysis organizations following implementation of the prospective payment system. The impact of the United States Prospective Payment System (PPS) "bundle payment system" on anemia management within small dialysis organizations (SDOs) was studied to evaluate the financia burden on SDOs. Facilities enrolled in the orig...

Torcigliani, A., 1950: Chronic anemia of blood-letting after ligature of the portal vein. Rassegna di Fisiopatologia Clinica E Terapeutica 22(1-2): 19-27

Gabler, M.; Scheiblhofer, S.; Kern, K.; Leitner, W.W.; Stoecklinger, A.; Hauser-Kronberger, C.; Alinger, B.; Lechner, B.; Prinz, M.; Vrtala, S.; Valenta, R.; Thalhamer, J.; Weiss, R., 2006: Immunization with a low-dose replicon DNA vaccine encoding Phl p 5 effectively prevents allergic sensitization. Background: Replicase-based DNA vaccines stimulate T(H)1-biased immune responses at ultralow doses and induce self-removal of transfected cells through apoptosis. Both aspects are important requirements for efficient and safe DNA-based immunother...

Testa, A.C.; Scambia, G.; Caruso, A., 2000: The clinical usefulness of preoperative intratumoral Doppler analysis in predicting lymph node metastasis in patients with endometrial carcinoma. Gynecologic Oncology 79(3): 522-523

Pronost, S.; Delecoeuillerie, G.; Rédini, F.; Paolozzi, L.; Vivien, D.; Galéra, P.; Loyau, G.; Pujol, J.P., 1993: Interleukin-1 and naproxen down-regulate the expression of IL-1 receptors in cultured human rheumatoid synovial cells (HRSC). Using affinity binding of [125I]-IL-1 alpha and Scatchard analysis, we demonstrate here that exposure of cultured synovial cells (HRSC) to NPX (10(-4) M) for 96 h decreased the binding of IL-1 by 20 to 35%. This effect results from a down-regulati...

Chikvashvili D.V., 1982: The effect of cations on the p nitrophenyl phosphatase activity of the sodium potassium atpase system. The effect of Mg2+ ions on the pNPPase [p-nitrophenylphosphatase] activity of the Na, K-ATPase system in rat brain was studied. Variation of the Mg2+-pNPP ratio does not cause significant changes of phosphatase activity. Mg2+ ions act as non-compe...

Nielsen., 1955: Studies on Enchytraeidae. 5. Factors causing seasonal fluctuations in numbers. Oikos, 62: 153-169