+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Hypercholesterolemia exacerbates ventricular remodeling in the rat model of myocardial infarction

, : Hypercholesterolemia exacerbates ventricular remodeling in the rat model of myocardial infarction. Journal of Cardiac Failure 12(5): 399-405

Detrimental left ventricular (LV) remodeling is exacerbated in hypercholesterolemic patients with myocardial infarction; however, this could result from either larger infarcts or more extensive remodeling itself in this population. Therefore, we sought to investigate whether high cholesterol feeding exacerbates LV remodeling and heart failure in rats with myocardial infarction independently from its influence on infarct size. Myocardial infarction was induced by permanent ligation of left coronary artery in rats fed normal and high-cholesterol diet and the animals were followed for 8 weeks. Hypercholesterolemic rats were matched with normocholesterolemic animals for infarct size 24 hours after infarction and exhibited more pronounced LV dilation at 8 weeks after infarction (LV systolic/diastolic diameter 8.1 +/- 0.2/10.2 +/- 0.3 versus 6.7 +/- 0.2/8.9 +/- 0.2, respectively, measured by echocardiography, P < .05 each). Pressure-volume curves obtained in isolated Langendorff-perfused hearts revealed higher diastolic LV volumes (1677 +/- 102 versus 1385 +/- 46 muL/kg body weight, P < .05) and hemodynamic examination demonstrated higher LV end-diastolic pressure (21.8 +/- 0.7 versus 18.7 +/- 1.0 mm Hg, P < .05) in hypercholesterolemic rats compared with normocholesterolemic animals. In a rat model of myocardial infarction, LV remodeling and heart failure are more pronounced in rats fed high-cholesterol diet in comparison to animals fed normal chow. This effect is independent from effect of hypercholesterolemia on infarct size.


PMID: 16762804

DOI: 10.1016/j.cardfail.2006.03.005

Other references

Rauh W.; Oberfield S.; Levine L.; New M., 1979: Dexamethasone suppressible hyper aldo steronism in childhood. European Journal of Pediatrics 130(3): 227

Gamalero, P.C., 1958: Effect of vitamin E on the blood lipid picutre in children. Minerva Pediatrica 10(46): 1342-1347

Rumstadt, B.; Schilling, D., 2010: Rupture of a superior mesenteric artery aneurysm. A 54-year-old patient presented with acute abdominal pain that had started after having a bowel movement. Ultrasound examination revealed free intraabdominal fluid with no signs of organ rupture. CT-scan showed a peripherally located ruptured aneu...

Guardado L.R.; Carminatti M.; Martins C.C., 2000: Efforts, results and future perspectives of the petroleum exploration in Brazil, seismic examples. International Geological Congress, Abstracts = Congres Geologique International, Resumes 31: (unpaginated

Copp, H.L., 2010: Are we all talking about the same thing?. Journal of Urology 182(1): 12-13

Housden, R.James.; Ma, Y.; Arujuna, A.; Nijhof, N.; Cathier, P.; Gijsbers, G.; Bullens, R.; Gill, J.; Rinaldi, C.Aldo.; Parish, V.; Rhode, K.S., 2014: Extended-field-of-view three-dimensional transesophageal echocardiography using image-based X-ray probe tracking. The use of ultrasound imaging for guidance of cardiac interventional procedures is limited by the small field of view of the ultrasound volume. A larger view can be created by image-based registration of several partially overlapping volumes, but...

Stark, N., 1965: Natural regeneration of Sierra Nevada mixed conifers after logging. Studies of natural reproduction following logging under unit area control started in 1948 at the Stanislaus-Tuolumne Experimental Forest in California. Results from 119 permanent and 468 temporary quadrats show that when logging preceded a good se...

Neuzillet, C.; Vullierme, M-Pierre.; Couvelard, A.; Sauvanet, A.; Levy, P.; Richard, Séphane.; Ruszniewski, P.; Hammel, P., 2010: Difficult diagnosis of atypical cystic pancreatic lesions in von Hippel-Lindau disease. von Hippel-Lindau disease is a progressive, autosomal dominant disorder with multiorgan involvement. There are 2 types of pancreatic lesions from von Hippel-Lindau disease: cystic lesions and endocrine pancreatic tumors. Only the latter type is po...

Chagas,; Prazeres Dos Santos, I.; Nascimento da Silva, L.Claudio.; Correia, M.Tereza.Dos.Santos.; Magali de Araújo, J.; Cavalcanti, M.da.Silva.; Lima,, 2017: Antimicrobial Activity of Cultivable Endophytic Fungi Associated with iHancornia Speciosa Gomes Bark. In this study, we evaluated the antimicrobial potential of cultivable endophytic fungi associated with <i>Hancornia speciosa</i> Gomes stem bark. Plant samples were collected in rainy (July 2010) and dry (January 2011) seasons. In tota...

Singal, E.M.; Solov'eva, N.K., 1974: Characteristics of some physiologic-biochemical properties of various representatives of the genus Micromonospora. Antibiotiki 19(12): 1075-1080