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Hypotheses, design, and methods for the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) Trial


, : Hypotheses, design, and methods for the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) Trial. American Journal of Cardiology 97(12a): 9g-19g

The Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) is a National Institutes of Health (NIH)-sponsored randomized clinical trial that evaluates treatment efficacy for patients with type 2 diabetes mellitus and angiographically documented stable coronary artery disease. Using a 2 x 2 factorial design, BARI 2D compares revascularization combined with aggressive medical treatment versus aggressive medical treatment alone; simultaneously, BARI 2D compares 2 glycemic control strategies, insulin sensitization versus insulin provision. All patients have goals of glycosylated hemoglobin values <7.0% and uniform control of hypertension, dyslipidemia, and obesity following recommended medical guidelines. The primary end point of BARI 2D is all-cause 5-year mortality analyzed by intention to treat, and the principal secondary end point is the combination of death, myocardial infarction, and stroke. A total of 2,368 patients have been enrolled at 49 clinical centers throughout North America, South America, and Europe. The study enrollment period was January 2001 through March 2005, and the patient treatment and follow-up phase is expected to extend at least through May 2007. Participants are treated at the local BARI 2D clinical sites on a monthly basis for the first 6 months and then every 3 months until the end of the study. Within BARI 2D, central management centers oversee the control of glycemia, plasma lipid levels, hypertension, and obesity. The randomized clinical trial collects data on patient symptoms, clinical measurements, medications, and clinical events as well as data from centralized evaluations of angiograms, electrocardiograms, nuclear stress tests, blood and urine specimens, and relative economic costs.

US$19.90

PMID: 16813734

DOI: 10.1016/j.amjcard.2006.02.023


Other references

Hinners, K.; Stratmann, J., 1984: Spacing experiment with Japanese larch in the Neumunster Forest District. Plots of [Larix leptolepis] were established in 1932 in Holstein at spacings of 1x1, 2x2, 3x3 or 4x4 m. Trees were measured at 51 yr old. Trees at wider spacings suffered from steady winds when young, although there were n.s.d. in ht. after 51 yr....

Setterfield, J.F.; Neill, S.; Shirlaw, P.J.; Theron, J.; Vaughan, R.; Escudier, M.; Challacombe, S.J.; Black, M.M., 2006: The vulvovaginal gingival syndrome: a severe subgroup of lichen planus with characteristic clinical features and a novel association with the class II HLA DQB1*0201 allele. The vulvovaginal gingival syndrome is an uncommon and severe variant of lichen planus characterized by erosions or desquamation of vulval, vaginal, and gingival mucosae with a predilection for scarring and stricture formation. We sought to define...

Seidl, V., 1983: Virus diseases of plum trees. Zahradnictvo 8(7): 303-305

Flynn, J.; Li, J.; Sleight, A.W.; Ramirez, A.P.; Subramanian, M.A., 2016: Structure and Properties of Ir-Containing Oxides with Large Spin-Orbit Coupling: Ba2In(2-x)Ir(x)O(5+δ). In this work, the solid solution series Ba2In(2-x)Ir(x)O5+δ (x = 0-1.4, 2) was synthesized, and its structural, magnetic, and charge-transport properties were measured. With increasing Ir content, three transitions in the room-temperature structu...

Claver Martin, Maria Dolores, 1998: Update on the evaluation and treatment of delirium. Delirium is a common disturbance in geriatric and psychogeriatric practice, and more so in hospitalized patients. Evolution will partially depend on a quick disorder identification, on the assessment and correction of the etiological involved fact...

Hubbard, G.B.; Thomison, J.B., 1977: Southern Medical Journal welcomes new editor (John B Thomison). Southern Medical Journal 70(9): 1031-1031

Kondombo, S.R., 2005: Improvement of village chicken production in a mixed (chicken-ram) farming system in Burkina Faso. The thesis aimed to describe village chickens and small ruminant production systems; identify various feeding regimens for village chickens and fattening sheep and investigate their advantage and limitations; identify which factors of the producti...

Whyte, B.B., 1962: After tonsillectomy. Nursing Times 58: 1280-1281

Bobrov, V.A.; Kolomiets, V.V., 1995: The effect of calcium-regulating hormones on calcium renal transportation in essential hypertension. Terapevticheskii Arkhiv 67(9): 42-45

Oishi, S.; Diener, E.; Lucas, R.E., 2007: The Optimum Level of Well-Being: Can People Be Too Happy?. Psychologists, self-help gurus, and parents all work to make their clients, friends, and children happier. Recent research indicates that happiness is functional and generally leads to success. However, most people are already above neutral in hap...