+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Identification of elevated carbohydrate-deficient transferrin (CDT) serum level as transferrin (Tf)-D-variant by means of isoelectric focusing

, : Identification of elevated carbohydrate-deficient transferrin (CDT) serum level as transferrin (Tf)-D-variant by means of isoelectric focusing. Zeitschrift für Gastroenterologie 42(9): 1049-1054

Many studies have shown carbohydrate-deficient transferrin (CDT) to be a sensitive and specific marker of chronic alcohol abuse. We present the case of a 23-year-old, healthy professional soccer player who caused a car accident due to alcohol consumption. Several CDT test results were elevated above the laboratory reference range and were considered to be caused by alcohol intake at a level commensurate with misuse and thus license reapplication was refused. In addition, assuming chronic alcohol abuse, the young man suffered from increasing social isolation. He was finally referred to our out-patient clinic for further evaluation on the assumption of a liver disease. Since chronic alcohol consumption was denied, and there was no evidence of liver disease, a qualitative characterization of the transferrin isoforms was performed. Isoelectric focusing of serum transferrin revealed a pattern atypical for chronic alcohol intake but detected a genetically determined transferrin (Tf)-D-variant. The changed amino acid sequence caused an overlapping of transferrin isoforms with different degrees of sialylation, thus revealing false-positive serum CDT values. Determination of this Tf-D-variant heterozygosity resulted in his social rehabilitation and license reinstatement. Thus, where the evidence for alcohol dependency is either uncertain or uncorroborated, qualitative isoelectric focusing of transferrin is a useful method for analyzing unexplained CDT elevations, thus increasing the value of CDT as a marker for chronic alcoholic abuse.


PMID: 15455284

DOI: 10.1055/s-2004-813272

Other references

Vucic, N., 1974: Contribution to the study of the problem for evaluating the quality of irrigation water. Acta Horticulturae 35: 7-93

Levorsen, R.I., 1976: The search for petroleum. Science 192(4243): 993-994

Zhang Bin; Zhang TaoLin; Zhao QiGuo, 1996: Soil erosion of various farming systems in subtropical China. To optimize land use systems, prevent erosion-induced degradation and restore degraded red soils in subtropical China, five cropping systems and four agroforestry systems were studied on red soils with a slope of 7 degrees . The results showed tha...

Burney, M.I., 1993: Transferring manufacturing technology. Producing essential vaccines in Pakistan. Polio, measles, rabies, tetanus, tuberculosis, and hepatitis cause much illness and death in Pakistan. Widespread and timely immunizations could, however, avert much of the associated morbidity and mortality. Pakistan therefore launched an Expande...

Bujor, P., 1904: Nouvelle contribution a l'etude de la faune des Lacs sales de Roumanie. Annales Universite Jassy, III 1-3

Hershko, C., 2005: Treating iron overload: the state of the art. Seminars in Hematology 42(2 Suppl 1): S2-S4

Madsen, F.J., 1941: Notiz uber eine Tornaria dem Kattegatt. Zoologischer Anzeiger, 186(7-8): 187-171

Sabatino, F., 1991: Home care: the wave of the future?. Trustee 44(11): 4-6

Pollard, S.E.; Neri, P.M.; Wilcox, A.R.; Volk, L.A.; Williams, D.H.; Schiff, G.D.; Ramelson, H.Z.; Bates, D.W., 2013: How physicians document outpatient visit notes in an electronic health record. Clinical documentation, an essential process within electronic health records (EHRs), takes a significant amount of clinician time. How best to optimize documentation methods to deliver effective care remains unclear. We evaluated whether EHR visi...

Anonymous, 1993: Consensus conference. "Antibioprophylaxis in a surgical setting". 10-11 December 1992, Faculté de Médecine Xavier Bichat. Cahiers D'anesthesiologie 41(3): 273-280