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Immune modulation with a staphylococcal preparation in fibromyalgia/chronic fatigue syndrome: relation between antibody levels and clinical improvement


, : Immune modulation with a staphylococcal preparation in fibromyalgia/chronic fatigue syndrome: relation between antibody levels and clinical improvement. European Journal of Clinical Microbiology & Infectious Diseases 23(2): 98-105

The aims of this study were to evaluate the serological response to treatment with staphylococcal vaccine in fibromyalgia/chronic fatigue syndrome patients and to explore the relationship between serological response and clinical effect. Twenty-eight patients, half of whom served as controls, were recruited from a 6-month randomised trial in which repeated administration of the staphylococcal toxoid vaccine Staphypan Berna (Berna Biotech, Switzerland) was tested against placebo. Antibody status against extracellular toxins/enzymes, cell-wall components, and enterotoxins was evaluated at baseline and at endpoint. The clinical response to treatment was recorded in rating scales. In the group receiving active treatment, significant serological changes were recorded, whereas no significant changes were found in controls. Treatment led to a significantly increased capacity of serum to neutralise alpha-toxin and a significant increase in serum IgG to alpha-toxin and lipase. Furthermore, the increase in these parameters combined paralleled the improvement in clinical outcome. Thus, the greater the serological response, the greater was the clinical effect. In conclusion, this explorative study has shown that repeated administration of the Staphypan Berna vaccine in patients with fibromyalgia/chronic fatigue syndrome causes a serological response to several staphylococcal antigens, particularly to certain extracellular toxins and enzymes. The results further show that this response is related to the clinical outcome of treatment.

US$19.90

PMID: 14735403

DOI: 10.1007/s10096-003-1062-8


Other references

Greven, R.; Juetten, P.; Scharf, H.-Dieter, 1993: A new stereoselective route to branched-chain nitro and amino sugars: Synthesis of both enantiomers of decilonitrose and avidinosamine. Short, efficient, and highly diastereoselective synthesis of the title carbohydrates (15, 21, and 22), components of new anthracycline antibiotics, on a gram scale from readily available keto sugar precursors 6 and 17 are described. The syntheses...

Horton, J.W.; White, J.; Maass, D., 1998: Protein kinase C inhibition improves ventricular function after thermal trauma. Objective: To examine the effect of protein kinase C (PKC) inhibition on cardiac performance and intracellular Ca2+ homeostasis. Design: Previous studies have shown that trauma impairs cardiac mechanical function, and recent studies suggest that P...

Barth, S.; Seifner, M.S.; Bernardi, J., 2015: Microwave-assisted solution-liquid-solid growth of Ge1-xSnx nanowires with high tin content. A microwave assisted growth procedure for the first bottom-up synthesis of germanium tin alloy (Ge1-xSnx) nanowires with constant diameter along their axis was developed. Ge1-xSnx nanowires with mean diameters of 190 ± 30 nm and a homogeneous dis...

Nakai T.; Miyamoto Y.; Shibata T., 1975: Studies on glyceraldehyde 3 phosphate dehydrogenase from kokanee muscle part 1 extraction studies and purification of the enzyme. Bulletin of the Faculty of Fisheries Hokkaido University 26(2): 201-206

Anonymous., 1981: The nesting of Ardea cinerea L. in Nord-bohemia region. Fauna Bohemiae Septentrionalis, 75 Nos 5-6

Mcintosh, R.; Burlton, F.W.E.; Mcreddie, G., 1995: Monitoring the density of a roe deer Capreolus capreolus population subjected to heavy hunting pressure. A 5 year study was undertaken in Kielder Forest to examine changes in pellet group counts, direct observations, body weight and potential fertility in a population of roe deer Capreolus capreolus subjected to heavy hunting pressure. Over the study...

Bernard, J.; Mathe, G.; Auvert, J., 1955: Experimental cytopenia of splenic origin: experimental blood cytopenia by extrahepatic derivation of splenic blood. La Semaine des Hopitaux 31(20): 1135-1140

Jimenez Aragon, J.G.; Carrillo Sanchez, J.L., 1978: Beneficial insect fauna on cotton intersown with maize as compared with cotton alone. Studies in the region of Ceballos, Durango State, Mexico, in 1974 to 1976 showed that maize interplanted with cotton protected the latter crop from damage by Heliothis zea (Boddie) because the females preferred to oviposit on maize rather than on...

Liebman, W.M., 1978: Recurrent diarrhea in older children associated with enteropathogenic E. coli. American Journal of Gastroenterology 70(6): 664-666

Botten, G., 1995: Anti-smoking action--a challenge for achievement of knowledge and wide distribution. Tidsskrift for den Norske Laegeforening 115(17): 2044-2045