+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Incidence of nonvertebral fractures in relation to time on treatment and bone density in glucocorticoid-treated patients: a retrospective approach

, : Incidence of nonvertebral fractures in relation to time on treatment and bone density in glucocorticoid-treated patients: a retrospective approach. Journal of Clinical Rheumatology 9(3): 170-175

The effects of duration of treatment and bone mineral density (BMD) on nonvertebral fracture in 560 glucocorticoid users were examined by using baseline and retrospective data from 2 parallel studies assessing the efficacy and safety of alendronate therapy. Baseline spine and hip BMD were significantly (P < 0.01) lower with increased time spent receiving glucocorticoids. Forty-three patients (7.7%) had experienced at least 1 nonvertebral fracture after starting glucocorticoid treatment. The hazard function for nonvertebral fracture occurrence increased significantly (P < 0.01) with time spent receiving glucocorticoids: fracture incidence per 1,000 person-years on glucocorticoids was 18 (< 5 years), 31 (5-10 years), and 35 (> 10 years). Patients with a history of nonvertebral fractures after starting glucocorticoid treatment had significantly lower lumbar spine (P < 0.01) and hip (< 0.01) BMD value than those without fractures. This retrospective analysis suggests that a BMD measurement of spine and hip may identify risk for nonvertebral fractures in a heterogeneous population of glucocorticoid users.


PMID: 17041453

DOI: 10.1097/01.RHU.0000073586.28977.31

Other references

Nordby, H.; Nøhr, Øyvind., 2010: Interactive emergency communication involving persons in crisis. We studied the dialogue between telephone operators at medical emergency communication centres in Norway and parents of children later diagnosed with sudden infant death syndrome. The aim was to understand how the parents experienced the communica...

Vaikasas, S.; Zdankus, N., 2005: Analysis of Lithuanian river channels bed stability (referring to Grishanin number). This paper reviews the estimation of river channel bed-formation processes in Lithuania on the basis of the integrated hydraulic and morphological criterion - Grishanin numbers M<sub>G</sub> and M<sub>A</sub>. It has been e...

Anonymous, 2001: Mini-scale rural infrastructure development. Report of the Second APO Multi-Country Study Mission on Integrated Local Community Development held in Hyderabad from 19 to 29 January 1999. This book includes 8 resource papers and 19 country papers presented at the Asian Productivity Organization's 2nd Multi-Country Study Mission on Integrated Local Community Development, which focused on small-scale rural infrastructure develop...

Khan, W.S.; Ahmad, Z., 1979: Better varieties of cotton for Central Canal Colonies of the Punjab. Factors responsible for the decline in the cotton area, total production and yield/ac in the Punjab are discussed. The new high-potential cv. B557 outyielded the standard cv. AC134, 149F and BS1 on farmers' fields by 93-205 kg lint/ac. Recomm...

Danielian, S.N.; Abakumov, M.M.; Kudriashova, N.E.; Sharifullin, F.A.; Popova, I.E.; Kvardakova, O.V.; Chernen'kaia, T.V.; Sidorova, I.E., 2011: Diagnostics and treatment of posttraumatic septic costal osteomyelitis. Results of treatment and diagnostics of 47 patients with posttraumatic septic costal osteomyelitis were analyzed. 26 patients had open and 21 - closed thoracic injuries. Major reasons of osteomyelitis tended to be the initial infection of the bony...

Malarkey W.B.; Daughaday W.H., 1971: Variable response of plasma growth hormone in acromegalic patients treated with medroxy progesterone acetate. Journal of Clinical Endocrinology & Metabolism 33(3): 424-431

Chuistova, I.P.; Sheremet, N.A.; Iarmak, T.D., 1985: Demodicosis of the eye. Oftalmologicheskii Zhurnal: 174-176

Aries, V.; Cheney, P.A.; Mossel, D.A., 1982: Ecological studies on the occurrence of bacteria utilizing lactic acid at pH values below 4.5. Sites within 2 cheese factories, a silage tower and silage pit and 2 pet food factories were investigated for lactic acid utilizing bacteria. The bacteria isolated, together with known lactic acid utilizing and aciduric bacteria, were tested for t...

Kapustina, A.P., 1979: Collection of spring bread wheat under test in the north west. Of 330 varieties from 38 countries tested in the north west of the USSR during 1976-77, the highest yielding were Sv60383, Svenno, Janetzkis Probat, Adler, Rokizka, Frisco, Koala, Sl. Gibrid 12889/51 [Sl. Hybrid 12889/51], Zlatka and Lutescens 128...

Alderman, C., 2002: Fair lady. Nursing Standard 15(32): 19-19