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Influence of age on metabolism of testosterone, dihydrotestosterone, and 3-alpha-androstanediol in muscle biopsies from patients with neuromuscular diseases

, : Influence of age on metabolism of testosterone, dihydrotestosterone, and 3-alpha-androstanediol in muscle biopsies from patients with neuromuscular diseases. Archives of Gerontology and Geriatrics 29(3): 223-230

We investigated the possible effect of age on the metabolism of androgens in muscle biopsies from patients with neuromuscular diseases. The conversion of testosterone, dihydrotestosterone (DHT) and 5-alpha-androstane-3-alpha-17-beta-diol (3-alpha-androstanediol) was measured in muscle biopsies from 24 patients with neuromuscular diseases and seven controls. The reductive metabolism of 3-alpha-HSDH was significantly higher than the oxidative metabolism. Significant metabolism of testosterone to DHT was not found. Only the age of the patients emerged as a significant negative predictor in a stepwise multiple linear regression model for V(max) and K(m) (Lineweaver-Burke plots) of the reductive metabolism of 3-alpha-HSDH. Therefore, altered metabolism of anabolic androgens in skeletal muscles could be demonstrated. We conclude that this could alter the androgenic catabolic/anabolic balance in the (androgenic target organ) skeletal muscle.


PMID: 15374055

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