geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Involvement of peripheral adenosine A2 receptors in adenosine A1 receptor-mediated recovery of respiratory motor function after upper cervical spinal cord hemisection


, : Involvement of peripheral adenosine A2 receptors in adenosine A1 receptor-mediated recovery of respiratory motor function after upper cervical spinal cord hemisection. Journal of Spinal Cord Medicine 29(1): 57-66

In an animal model of spinal cord injury, a latent respiratory motor pathway can be pharmacologically activated through central adenosine A1 receptor antagonism to restore respiratory function after cervical (C2) spinal cord hemisection that paralyzes the hemidiaphragm ipsilateral to injury. Although respiration is modulated by central and peripheral mechanisms, putative involvement of peripheral adenosine A2 receptors in functional recovery in our model is untested. The objective of this study was to assess the effects of peripherally located adenosine A2 receptors on recovery of respiratory function after cervical (C2) spinal cord hemisection. Respiratory activity was electrophysiologically assessed (under standardized recording conditions) in C2-hemisected adult rats with the carotid bodies intact (H-CBI; n=12) or excised (H-CBE; n=12). Animals were administered the adenosine A2 receptor agonist, CGS-21680, followed by the A1 receptor antagonist, 1,3-dipropyl-8-cyclopentylxanthine (DPCPX), or administered DPCPX alone. Recovered respiratory activity, characterized as drug-induced activity in the previously quiescent left phrenic nerve of C2-hemisected animals in H-CBI and H-CBE rats, was compared. Recovered respiratory activity was calculated by dividing drug-induced activity in the left phrenic nerve by activity in the right phrenic nerve. Administration of CGS-21680 before DPCPX (n=6) in H-CBI rats induced a significantly greater recovery (58.5 +/- 3.6%) than when DPCPX (42.6 +/- 4.6%) was administered (n=6) alone. In H-CBE rats, prior administration of CGS-21680 (n=6) did not enhance recovery over that induced by DPCPX (n=6) alone. Recovery in H-CBE rats amounted to 39.7 +/- 3.7% and 38.4 + 4.2%, respectively. Our results suggest that adenosine A2 receptors located in the carotid bodies can enhance the magnitude of adenosine A1 receptor-mediated recovery of respiratory function after C2 hemisection. We conclude that a novel approach of targeting peripheral and central adenosine receptors can be therapeutically beneficial in alleviating compromised respiratory function after cervical spinal cord injury.

US$29.90

PMID: 16572566


Other references

Li, W.M.; Chan, H.N.; Lee, N.T.K.; Xie, Y.B.; Ho, C.M.; Carlier, P.R.; Pang, Y.P.; Tsim, K.; Li, M.T.; Han, Y.F., 2002: Bis tacrine, a promising anti alzheimers agent, attenuates glutamate induced apoptosis in rat cerebellar granule neurons. We have previously reported that bis(7)-tacrine had exhibited neuroprotective effects against H2O2 and ischemia insults. Here we investigated the neuroprotective effect of bis(7)-tacrine, a novel dimeric AChE inhibitor, on glutamate-induced excito...

Matschie, P., 1918: Ein Schwarzbuffel des Kafue-Gebietes. Sitzungsberichte der Gesellschaft Naturforschender Freunde zu Berlin, 133-140

Schuster, E.G., 1983: Evaluating nonindustrial private landowners for forestry assistance programs: a logistic regression approach. A study aimed at identifying groups of private landowners who would be most responsive to assistance programmes providing management advice. Four logistic regression models were developed from questionnaire data collected from landowners in Montan...

Yuan, D.; Chen, Z.; Zhou, Y.; Xiao, D.; Liu, K.; Xiang, X.; Deng, L.; Dong, H.; Feng, G., 2016: A Regenerative Intervertebral Disc Endplate Based on Biomimetic 3-Dimensional Scaffolds. Fabrication and characterization of a regenerative intervertebral disc (IVD) cartilaginous endplate (CEP) based on tissue culturing on a biomimetic scaffold. To fabricate a regenerative CEP to support nutrients and metabolites exchange between IVD...

Karkos, C.D.; Bruce, I.A.; Lambert, M.E., 2001: Use of the intra-aortic balloon pump to stop gastrointestinal bleeding. Temporary aortic occlusion can be lifesaving in selected conditions. We describe the unorthodox use of an intra-aortic balloon pump without counterpulsation to achieve temporary vascular control in a patient with shock caused by rapid upper gastro...

Volker, O., 1965: Seltene Limicolen im Gebiet der nordichen Oberrheinebene. Ornithologische Mitteilungen Stuttgart, 17: 120-121

Teisinger, J.; Roubal, J.; Mueller, J.; Bena, E.; Chvapil, M.; Kubik, S.; Pleskova, A.; Hubac, M.; Ulrich, L., 1963: 10 Years' Activity Of The Institutes Of Industrial Hygiene And Occupational Diseases In Prague And Bratislava. Pracovni Lekarstvi 15: 2-24

Krieger, N.S., 1991: Evidence for sodium-calcium exchange in rodent osteoblasts. Annals of the New York Academy of Sciences 639: 660-662

Giroux, F., 1976: A Canadian hospital security survey. Dimensions in Health Service 53(4): 8-10, 12

Charrin Victor, 1939: Les laves andesitiques du Massif Central. The andesitic lavas of Volvic, Central Massif, France, have a world-wide reputation for resistance to heat and acid. They are used in place of feldspars in the production of refractories. The lava fills a valley with a granite basement, occurring...