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Laetrile for cancer: a systematic review of the clinical evidence

, : Laetrile for cancer: a systematic review of the clinical evidence. Supportive Care in Cancer 15(6): 583-595

Many cancer patients treated with conventional therapies also try 'alternative' cancer treatments. Laetrile is one such 'alternative' that is claimed to be effective by many alternative therapists. Laetrile is also sometimes referred to as amygdalin, although the two are not the same. The aim of this review is to summarize all types of clinical data related to the effectiveness or safety of laetrile interventions as a treatment of any type of cancer. All types of clinical studies containing original clinical data of laetrile interventions were included. We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE (from 1951), EMBASE (from 1980), Allied and Complementary Medicine (AMED), Scirus, CancerLit, Cumulative Index to Nursing and Allied Health (CINAHL; all from 1982), CAMbase (from 1998), the MetaRegister, the National Research Register, and our own files. For reports on the safety of laetrile, we also searched the Uppsala database. No language restrictions were imposed. Thirty six reports met our inclusion criteria. No controlled clinical trials were found. Three articles were nonconsecutive case series, 2 were consecutive case series, 6 were best case series, and 25 were case reports. None of these publications proved the effectiveness of laetrile. Therefore, the claim that laetrile has beneficial effects for cancer patients is not supported by sound clinical data.


PMID: 17106659

DOI: 10.1007/s00520-006-0168-9

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Clercq, K. de; Lambot, M.; Hubert, P.; Strobbe, R.; Debecq, J.; Letesson, J.J.; Danes, M., 1996: Bovine lymphocyte responses to foot-and-mouth disease virus (FMDV) antigens. Peripheral blood mononuclear cells (PBMC) from cattle vaccinated with commercial Belgian FMDV vaccine proliferated to FMDV O1 in vitro. The lymphocytes largely responsible for the proliferative response to the virus were T-helper cells as defined...

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Mew G.; Johnston A.D., 1979: The use of soil survey information in sieve planning for forestry an example from the west coast south island new zealand. Sieve planning has not been described in detail previously as a method for aiding forestry planning in New Zealand. The stages leading to the production of a combination overlay that ranks potential uses or values for exotic forestry, indigenous f...

Barral, A.; Costa, J.M.L.; Bittencourt, A.L.; Barral Netto, M.; Carvalho, E.M., 1995: Polar and subpolar diffuse cutaneous leishmaniasis in Brazil: clinical and immunopathologic aspects. Diffuse cutaneous leishmaniasis (DCL) is a rare manifestation of human leishmaniasis, characterized by multiple, slowly progressive nodules or plaques without ulceration, involving almost the entire body. It has been suggested, that DCL results fr...

Schramm, G., 1957: The significance of the Chinese drug Pai-Chi for pharmaceutical practice in China-Short communication. A resume of 3 Chinese articles published in 1955 concerning Bletilla striata, the tubers of which are rich in mucilage, and this is considered as an emulsifier and as a tablet excipient. 4 refs.

Swarnalatha, A.M., 1992: Assessing the effectiveness of four teaching approaches in increasing the knowledge of rural mothers in nutrition. The focus of this paper is the mechanisms by which nutritional information is passed on to target groups. The success of nutritional information programmes often depends on the approach taken. The study was conducted in four contiguous villages, n...

Stenseth, NC., 1985: Models of bank vole and wood mouse populations. Symposia of the Zoological Society of London, 339-376 No. 55

Balch, N.; Ellis, D.; Littlepage, J.; Marles, E.; Pym, R., 1976: Monitoring a deep marine waste water outfall. An intensive initial monitoring program assessed the environmental impact of discharging comminuted raw municipal wastewater at a depth of 200 ft (61 m) in the Strait of Juan de Fuca off Victoria, British Columbia, Canada. Of the several water qua...

Real F.X.; Egea G.; Franci C.; Schussler M.H.; Welt S., 1990: Characterization of a new in vitro model for the study of mucin synthesis. Journal of Cancer Research & Clinical Oncology 116(SUPPL PART 1): 314

Włodarski, K.; Włodarski, Pł., 2009: Leptin as a modulator of osteogenesis. Leptin, a hormone secreted by adipose tissue, but also by several other tissues, has a dual effect on bone, acting by two independent mechanisms. As a signal molecule with growth factor characteristics, leptin is able to stimulate osteoblastic cel...