geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Living related liver transplantation for Wilson's disease: clinical study of 32 cases


, : Living related liver transplantation for Wilson's disease: clinical study of 32 cases. Zhonghua Yi Xue Za Zhi 86(46): 3290-3293

To summarize the experience in donor selection and surgical outcomes of living related liver transplantation (LRLT) for Wilson's disease (WD). Thirty-two WD patients, 29 children and 3 being over 14, underwent LRLT because of chronic advanced liver disease (29 cases) or fulminant hepatic failure (3 cases) among which 13 cases showed neurological dysfunction. The donors, including 7 fathers and 25 mothers, had their serum ceruloplasmin levels within normal limit or slightly lower and their 24-hour urine copper < 100 microg. The modes of operation included orthotopic partial liver transplantation (31 cases) and orthotopic accessory partial liver transplantation (1 case). The patients were followed p for 3-63 months postoperatively. Two patients die in the intraoperative period, and 2 died of bile leakage and severe rejection combined with infection. Twenty-eight patients survived, of which 2 had hepatic artery thrombosis and underwent retransplantation of cadaveric liver, one had anatomic stenosis 8 months after the original transplantation and underwent Roux-en-Y hepaticojejunostomy, 2 had chronic rejection 22 and 28 months after the LRLT respectively and were successfully rescued by switching their primary immunosuppressor from cyclosporine A to FK506. Eleven patients with neurological dysfunctions all showed long-term survival and their extrapyramidal signs and speech disorders, and dyskinesia all were alleviated. LRLT is the treatment of choice for WD patients with chronic advanced liver disease and fulminant hepatic failure. After LRLT the disorders of the nervous system are alleviated.

US$29.90

PMID: 17313814


Other references

Nagarajah, S., 2016: Exosome Secretion - More Than Simple Waste Disposal? Implications for Physiology, Diagnostics and Therapeutics. Less than 100 nm in size and spherical in form - exosomes - vesicles expelled and taken up by cells, have ignited a new-found fascination. One which is derived from the sheer variety of exosomal content, ranging from microRNAs to transcription fac...

Ethiraj, S.S.resh, E.; Onkarayya, H., 1979: Nature of yeasts present on grapes grown in South India and in their wines. Vitis 18(2): 161-164

Matsumura M.; Ochi K., 1988: Effects of co 2 acidosis on the calcium transients in xenopus skeletal muscle fiber measured by arsenazo iii. Journal of the Physiological Society of Japan 50(8-9): 529

Nash, M.R.; Lynn, S.J.; Stanley, S.; Carlson, V., 1987: Subjectively complete hypnotic deafness and auditory priming. The present study examined the cognitive and attentional mechanisms by which auditory information is maintained out of awareness during complete hypnotic deafness. Adopting a methodology from recent work on subliminally presented pattern-masked wo...

Bi, W.; Ye, C.; Xiao, C.; Tong, W.; Zhang, X.; Shao, W.; Xie, Y., 2014: Spatial location engineering of oxygen vacancies for optimized photocatalytic H2 evolution activity. Enhanced H2 evolution efficiency is achieved via manipulating the spatial location of oxygen vacancies in niobates. The ultrathin K4 Nb6O17 nanosheets which are rich in surface oxygen vacancies show enhanced optical absorption and band gap narrowi...

Kot P.A., 1977: Canine cardio vascular responses to prostaglandin i a newly discovered product of arachidonic acid metabolism. Clinical Research: 221a

Kelley, S.T.; Cassirer, E.Frances.; Weiser, G.C.; Safaee, S., 2006: Phylogenetic diversity of Pasteurellaceae and horizontal gene transfer of leukotoxin in wild and domestic sheep. Wild and domestic animal populations are known to be sources and reservoirs of emerging diseases. There is also a growing recognition that horizontal genetic transfer (HGT) plays an important role in bacterial pathogenesis. We used molecular phyl...

Agrawal, R.P., 1972: Oxidation of soil organic matter and microaggregates in soils. The effectiveness of H2O2 oxidation of the organic matter after various pretreatments of 3 vertisols with varying particle size distribution and chemical properties was studied. H2O2 oxidation was ineffective after mechanical dispersion, water soa...

Tucholke Brian E.; Hollister Charles D., 1972: Late Pleistocene and Holocene Sedimentation in the western Gulf of Maine. Eos, Transactions, American Geophysical Union: , Pages 422. 1972.

Anonymous, 2005: 2005 Poultry Science Subject Index. Poultry Science 84(12): 30-46