geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Methylphenidate fails to improve gait and muscle tone in patients with sporadic and hereditary spastic paraplegia


, : Methylphenidate fails to improve gait and muscle tone in patients with sporadic and hereditary spastic paraplegia. Movement Disorders 21(9): 1468-1471

Based on its action on multiple neurotransmitters, including dopamine, methylphenidate (MPH) is of growing interest as a possible treatment option for several movement disorders. Of special interest are diseases that share gait disturbance and cognitive decline. Based on a single case observation in a patient with hereditary spastic spinal paraplegia (HSP) in which gait was improved with MPH, we performed an open-label study with a longitudinal follow-up in 22 patients with HSP and its sporadic form (SSP). The patients were treated for 6 months with 60 mg of MPH per day. Computerized gait analysis and different scores were performed at baseline, after 6 weeks, and after 6 months of treatment. Although at 6 weeks, the gait velocity was somewhat improved, the drug failed to show any effect on other gait parameters and had no beneficial effect at all after 6 months. Although MPH is of interest for several movement disorders, our study did not show a beneficial effect.

US$19.90

PMID: 16705687

DOI: 10.1002/mds.20973


Other references

Lerner, B.H., 2009: When diseases disappear--the case of familial dysautonomia. New England Journal of Medicine 361(17): 1622-1625

WangYanMei; SuShuChai; ZhaiMingPu; ChengLili; HuangWuGang; MaTianXiao, 2008: Genetic analysis of genus Corylus in China by SSR. To detect the genetic diversity of genus <i>Corylus</i> in China, 7 species (variety) of <i>Corylus</i> were analyzed using SSR markers. Forty-three accessions of 7 species (variety) presented 67 alleles in 7 SSR loci from...

Paumi, C.; Townsend, A.J.; Morrow, C.S., 2001: Role of multidrug resistance protein 1 (MRP1) and glutathione S-transferase A1-1 in alkylating agent resistance. We investigated the role of phase II (conjugation) and phase III (efflux) detoxification of the anticancer drugs melphalan (MLP) and chlorambucil (CHB). Although both drugs are substrates of Alpha-class glutathione Stransferases (GST) and the mono...

Noonan, G.O.; Ackerman, L.K.; Begley, T.H., 2011: Concentration of bisphenol A in highly consumed canned foods on the U.S. market. Metal food and drink cans are commonly coated with epoxy films made from phenolic polymers produced from bisphenol A (BPA). It is well established that residual BPA monomer migrates into can contents during processing and storage. While a number o...

Rank, B.K.; Wakefield, A.R., 1948: Reconstruction of opposition digits for mutilated hands. Australian and New Zealand Journal of Surgery 17(3): 172-188

Leao, P.C. de S.; Costa, J.G. da, 2003: Estimates of repeatability and path coefficients on grapes. A study was conducted to estimate the repeatability coefficient, the minimum number of evaluations to which a trait should be subjected and the effect of the inter-relationships of five characters on grapevine (Vitis vinifera) yield, aiming at get...

Anonymous, 1993: Rural land use in Asia and the Pacific: Report of an APO Symposium 29th September-6th October, 1992 Tokyo, Japan. Rapid population growth and accelerated urbanization have created an ever-increasing demand and pressure on the natural resource base in the rural areas, resulting in excessive deforestation, degradation of soils and various forms of pollution. As...

Fell, M.J.; Katner, J.S.; Rasmussen, K.; Nikolayev, A.; Kuo, M-Shang.; Nelson, D.L.G.; Perry, K.W.; Svensson, K.A., 2012: Typical and atypical antipsychotic drugs increase extracellular histamine levels in the rat medial prefrontal cortex: contribution of histamine h(1) receptor blockade. Atypical antipsychotics such as clozapine and olanzapine have been shown to enhance histamine turnover and this effect has been hypothesized to contribute to their improved therapeutic profile compared to typical antipsychotics. In the present stu...

Roth, Hans, 1941: Occurrence of Trichostrongylus colubriformis in the guinea pig. A full-grown [male] specimen is descr. from the small intestine of a young guinea pig, experimentally infected with trichina larvae.

Altman, K.I.; Evans, E.A., 1947: Enzymic synthesis of triphosphopyridine nucleotide in cell-free extracts. Aqueous extracts of pigeon liver acetone powder contained an enzyme system capable of synthesizing triphosphopyridine nucleotide (TPN) when adenosine tri-phosphate (ATP) was added. Maximal synthesis was observed with a system containing nicotinami...