geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Molecular biology of biological clock--genetic regulation of circadian rhythm and sleep


, : Molecular biology of biological clock--genetic regulation of circadian rhythm and sleep. No to Hattatsu. Brain and Development 38(4): 247-252

Circadian rhythm is a universal biological property functioning in most living species on the earth from bacteria and plants to animals. The molecular mechanisms creating this rhythm have recently been elucidated and the transcriptional feedback loop regulation of 'clock genes' is regarded as essential for all species studied so far. Both mammals and insects share the similar clock genes, which highlights the long conservation of circadian rhythm at the genetic level. Sleep and arousal cycles in mammals are known to be regulated by both homeostatic and circadian processes, but the genetic machinery for sleep regulation is still unclear. Recently, it has been reported that insects also have sleep-like behavior, and we showed that insects use dopamine as a regulator of their sleep/arousal cycling, which strongly suggests the similarity of arousal regulation between insects and mammals at the molecular level. In this review, these recent advancements of the molecular understanding of circadian rhythm and sleep/arousal regulation are outlined.

US$29.90

PMID: 16859185


Other references

Urban, P.P.; Keilmann, A.; Teichmann, E.M.; Hopf, H.C., 2001: Sensory neuropathy of the trigeminal, glossopharyngeal, and vagal nerves in Sjogren's syndrome. Isolated cranial nerve involvement in primary Sjogren's syndrome (primary SS) has rarely been described. We report the case of a patient with sensory neuropathy of the trigeminal and also the glossopharyngeal and vagal nerves, which has not b...

Kornianskiĭ, G.P., 1969: Professor Grigoriĭ Pavlovich Kornianskiĭ (on his 70th birthday). Voprosy Neirokhirurgii 33(1): 60-61

Aparicio, J.F.; De los Reyes-Gavilán, C.G.; Barbés, C.; Hardisson, C.; Sánchez, J., 1988: A non-specific deoxyribonuclease with restriction function in Streptomyces glaucescens. A non-specific deoxyribonuclease with a possible role in the restriction of some actinophages was detected in Streptomyces glaucescens ETHZ 22794. Production of this enzyme activity was influenced by the medium composition, indicating nutritional...

Guo, M.; Rupe, M.A.; Zinselmeier, C.; Habben, J.; Bowen, B.A.; Smith, O.S., 2004: Allelic variation of gene expression in maize hybrids. Allelic expression variation of nonimprinted autosomal genes has recently been uncovered in mouse hybrids and humans. The allelic expression variation is attributed to differences in noncoding DNA sequences and does not involve epigenetic regulati...

Luo, J.-Guang; Wang, X.-Bing; Kong, L.-Yi, 2007: Gypsophin: A novel alpha-glucosidase inhibitory cyclic peptide from. An unusual new cyclic peptide with a pyrrolidine-2,5-dione unit, gypsophin (1), was isolated from Gypsophila oldhamiana. Its structure determined by application of the Marfey's method and the single-crystal X-ray diffraction. Compound I exhib...

Giguere J F.; Dejoseph M.R.; Hawkins R.A.; Butterworth R.F., 1989: Regional cerebral glucose utilization in portal systemic encephalopathy. Hepatology 10(4): 590

Shaw, CE., 1961: Another generation of Galapagos giants. Zoonooz, 34(12): 10-15

Babenko, N.A.; Filonenko, N.S.; Vil'iasen'or, V.S.; Nikitin, V.N., 1991: Stimulation of phospholipase D by thyroid hormones in hepatocytes of rats of various ages and thyroid status. Doklady Akademii Nauk SSSR 320(3): 745-748

Levin, A.B.; Hadgkiss, E.J.; Weiland, T.J.; Jelinek, G.A., 2014: Meditation as an adjunct to the management of multiple sclerosis. Background. Multiple sclerosis (MS) disease course is known to be adversely affected by several factors including stress. A proposed mechanism for decreasing stress and therefore decreasing MS morbidity and improving quality of life is meditation....

Maurya, S.Rajkumar.; Mahalakshmi, R., 2015: VDAC-2: Mitochondrial outer membrane regulator masquerading as a channel?. The voltage-dependent anion channels (VDACs) are the workforce of mitochondrial transport and as such are required for cellular metabolism. The elaborate interplay between mitochondria and the apoptotic pathway supports a role for VDACs as a major...