geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Molecular mechanism of wendan tang in prevention of lipid metabolism disorder in adult rats


, : Molecular mechanism of wendan tang in prevention of lipid metabolism disorder in adult rats. Zhongguo Zhong Yao Za Zhi 28(12): 1184-1187

To elucidate the molecular mechanism of Wendan Tang in prevention of lipid metabolism disorder in adult rats. On the basis of hyperlipidemia rat models, triglycerides (TG), total cholesterol (TC) in serum, activities of lipase (LA), lipoprotein lipase (LPL), hepatic lipase (HL) in liver, parts of hemogram and hepatic LDLR mRNA levels were investigated 21 days after the feeding of atherogenic diet. Wendan Tang significantly reduced the serum TG, TC and increased the activity of LPL and LA, but caused no chang in HL. The result of RT-PCR test showed that high fat and high cholesterol feeding could significantly induce the reduction of LDLR mRNA levels, while Wendan Tang could increase hepatic LDLR density. Wendan Tang can prevent disorder of lipid metabolism by regulating TC, TG, LDL-c through upregaulation of LDLR transcription level and improving antioxidant ability.

US$29.90

PMID: 15617508


Other references

Pelletier, J.P.erre; Lascau Coman, V.; Jovanovic, D.; Fernandes, J.C.; Manning, P.; Currie, M.G.; Martel Pelletier, J., 1998: The selective in vivo inhibition of iNOS in experimental OA is associated with an in situ reduction of tissular levels of IL-1beta, MMP, iNOS, nitrotyrosine and COX-2. Arthritis & Rheumatism 41(9 SUPPL ): S342, Sept

Smith Curtis, 1983: Geology, depositional environments, and coal resources of the Mt. Pennell 2 NW Quadrangle, Garfield County, Utah. Abstracts with Programs - Geological Society of America 15(5): 289

Ruggiero, C.; Giacomini, M.; Calegari, F.; Berti, R.; Bertone, S.; Casareto, L., 1993: Interpretation of gascromatographic data via artificial neural networks for the classification of marine bacteria. We propose a new method for classification of marine bacteria. This method uses gaschromatograms, which contain information of fatty acid percentage contents of the fresh isolate. For the interpretation of these gaschromatograms we use a surpervis...

Mangi, Q.; Ridgway, P.F.; Ibrahim, Z.; Evoy, D.; Ridgway, R.F., 2004: Dislocation of the mandible. We report the first case of bilateral temporomandibular joint (TMJ) dislocation in a woman after endoscopy. We go on to discuss the case reports published in the literature, with particular focus on potential factors that may predispose to this co...

Fox D.G.; Emmick D.L.; Chase L.E.; Sniffen C.J., 1991: Performance of grazing holstein heifers supplemented with slowly degraded protein. The most common use of hill land in New York state is for pasturing dairy replacement heifers (Bos taurus L.). Previous research at Cornell University indicates that pasture containing over 75% total digestible nutrients (TDN) and 16% protein can...

Jager, M.J.; Claas, F.H.; Witvliet, M.; van Rood, J.J., 1986: Correspondence of the monocyte antigen HMA-1 to the non-HLA antigen 9a. Monocyte-specific antibodies are detrimental to bone marrow and renal transplantation. By using human antimonocyte sera we were able to identify two monocyte-specific antigens, human monocyte antigen 1 and 2 (HMA-1 and HMA-2). The presence of HMA-...

Hiari A.; Kopp M.L., 1992: The results of structural-kinematic interpretation of Landsat images of the Southeast Caucasus. Moscow University Geology Bulletin 47(5): 80-83

Prabha, T.; Dora Babu, M.; Priyambada, S.; Agrawal, V.K.; Goel, R.K., 2004: Evaluation of Pongamia pinnata root extract on gastric ulcers and mucosal offensive and defensive factors in rats. Effect of methanolic extract of P. Pinnata roots (PPRM) was studied against various experimental gastric ulcer models and offensive and defensive gastric mucosal factors in rats. An initial dose-response study using 12.5-50 mg/kg P. Pinnata root e...

Pan, J.J.; Clay, K., 2001: Infection by the systemic fungus Epichloe glyceriae alters clonal growth of its host Glyceria striata. Ecological Society of America Annual Meeting Abstracts 86: 172

Sandin, M.; Allenmark, S.; Edebo, L., 1992: Bacterial uptake of octyl ethanolamine increases with pH. The uptake of octyl ethanolamine (C8EA) by Pseudomonas pseudoalcaligenes was determined at pH 7.1-10.0. At pH 9.1 the total uptake was nearly three times higher and at pH 10.0 four times higher than at pH 7.1. Also the initial rate of uptake was l...