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Multidrug resistance 1 gene polymorphism and susceptibility to inflammatory bowel disease

, : Multidrug resistance 1 gene polymorphism and susceptibility to inflammatory bowel disease. Inflammatory Bowel Diseases 13(5): 516-523

Several studies have evaluated the role of the multidrug resistance 1 gene (MDR1) polymorphism, which encodes the membrane-bound efflux transporter P-glycoprotein 170, in determining susceptibility to and disease behavior in inflammatory bowel disease (IBD), but with conflicting results. A total of 211 patients with Crohn's disease (CD), 97 patients with ulcerative colitis (UC), and 212 control subjects were investigated for the presence of MDR1 G2677T/A and C3435T polymorphisms. Genotype frequencies of CD and UC patients were compared to those observed in a control population. Genotype-phenotype correlations with major clinical features were also established and estimated risks (odds ratio [OR] with 95% confidence interval [CI]) for the mutations were calculated by a logistic regression analysis and multiple correspondent analysis. No significant difference was observed for genotype frequencies for both MDR1 G2677T/A and C3435T polymorphisms on overall disease susceptibility for either CD or UC patients compared with control subjects. A significant association was found between the MDR1 C3435T polymorphism and patients with ileo-colonic CD (OR = 3.34; 95% CI: 1.34-8.27). Interestingly, a negative association was found between MDR1 C3435T polymorphism in patients with a positive family history for IBD (OR = 0.44; 95% CI: 0.20-0.95) and articular manifestations (OR = 0.29; 95% CI: 0.13-0.68). Both susceptible and protective effects were identified. No significant association between G2677T/A polymorphism and any specific subphenotypes was found, nor was there any association with subphenotypic categories of UC and both single nucleotide polymorphisms. The results of our study suggest that MDR1 gene polymorphism could have a role in determining susceptibility to IBD. The variability of this possible effect in the several studies reported so far may be the indirect expression of the complex role played by the MDR1 gene and its product, P-glycoprotein 170, in the regulation of host-bacteria interactions and in the pathogenesis of IBD.


PMID: 17260353

DOI: 10.1002/ibd.20108

Other references

Rezai Gharai, L.; Nashawati, E.; Poulton, T.B., 2017: Aortic Arch Pseudoaneurysm, a Complication of a Tracheal Expandable Stent (Wallstent). Journal of Bronchology & Interventional Pulmonology 24(4): E56-E58

Robinson, B.L., 1930: The Stevias of Paragua. A treatment of 14 species and their varieties known to occur in Paraguay. Includes (p. 83) the first description of S. estrellensis Hassl., hitherto an herbarium name.

Phai, P.; Andreev, V.S., 1976: Cyto genetic effects of chemical and physical mutagens on developing embryos of nigella damascena. An original technique is developed for treating gametes, zygotes and early embryos of N. damascena L. with chemical and physical mutagens. The delay in fertilization, the slowing down of the rate of cell division in the embryo and endosperm after...

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Dillman, R.; Selvan, S.; Schiltz, P.; Peterson, C.; Allen, K.; Depriest, C.; Mcclay, E.; Barth, N.; Sheehy, P.; De-Leon, C.; Beutel, L., 2004: Phase I/II trial of melanoma patient-speciric vaccine of proliferating autologous tumor cells, dendritic cells, and GM-CSF: Planned interim analysis. Aim: The aim of this study was to investigate the feasibility, safety, and clinical efficacy of patient-specific dendritic cell vaccines in patients with metastatic melanoma. A planned interim analysis was conducted on the first 20 patients. Metho...

Tsubuki, S.; Kawasaki, H.; Saito, Y.; Miyashita, N.; Inomata, M.; Kawashima, S., 1993: Purification and characterization of a Z-Leu-Leu-Leu-MCA degrading protease expected to regulate neurite formation: a novel catalytic activity in proteasome. A tripeptide aldehyde protease inhibitor, benzyloxycarbonyl(Z)-Leu-Leu-leucinal (ZLLLal), initiates neurite outgrowth in PC12 cells at an optimal concentration of 30 nM. This result suggests the existence of a protease which regulates neurite form...

Lupidi, G.; Angeletti, M.; Eleuteri, A.M.; Tacconi, L.; Coletta, M.; Fioretti, E., 1999: Peroxynitrite-mediated oxidation of fibrinogen inhibits clot formation. The clotting activity of human fibrinogen was fully inhibited in vitro by peroxynitrite. The decrease of activity followed an exponential function and the concentration of peroxynitrite needed to inhibit 50% of fibrinogen clotting was 22 muM at 25...

Artemenko, A.R.; Kurenkov, A.L.; Filatova, E.G.; Nikitin, S.S.; Kaube, H.; Katsarava, Z., 2008: Effects of topiramate on migraine frequency and cortical excitability in patients with frequent migraine. We studied the excitability of the visual and motor cortex in 36 patients with frequent migraine without aura (30 women, mean age 38.6 +/- 10.0 years) before and after treatment with topiramate (100 mg/day) using transcranial magnetic stimulation....

Itoh, T.J.; Ichihara, K.; Hotani, H., 2001: Examination of the mode of MAP2 binding onto microtubule lattice with Zn-sheet. Cell Structure & Function 26(5): 465, October

Orellana, L.H.; Chee-Sanford, J.C.; Sanford, R.A.; Löffler, F.E.; Konstantinidis, K.T., 2017: Year-round shotgun metagenomes reveal stable microbial communities in agricultural soils and novel ammonia oxidizers responding to fertilization. The dynamics of individual microbial populations and their gene functions in agricultural soils, especially after major activities such as nitrogen (N) fertilization, remain elusive but are important for better understanding nutrient cycling. Here...