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Myelodysplastic syndromes

, : Myelodysplastic syndromes. Annals of the New York Academy of Sciences 1028: 400-408

Efforts made during the last few years have helped unravel the complex pathogenesis of the myelodysplastic syndromes (MDS). A large number of studies, made possible by the introduction of newer technologies, have led to major progress in understanding the heterogeneous genetic and biological abnormalities contributing to the development and progression of myelodysplasia. Better insights into these pathogenetic processes will aid the development of newer and more successful therapies for MDS patients. The identification of specific genes involved in the emergence and progression of the myelodysplastic clone has extended biological findings into the clinic. Recently, several clinical trials have used selective compounds to target and inhibit the disrupted signal transduction pathway in myelodysplastic patients. The demonstration of genetic abnormalities present not only in MDS patients but also in acute myeloid leukemia (AML) patients or in chronic myeloproliferative disorders (CMPD) has prompted extension of a number of clinical trials from AML and CMPD to MDS patients. In spite of this, the more complex and heterogeneous pathogenesis underlying the myelodysplastic process is responsible for the often different and in same cases worse clinical results obtained in MDS patients. Finally, the identification of myelodysplasia-associated antigens that may be targeted by an immunotherapeutic approach represents a future perspective in tailored therapy for MDS patients.


PMID: 15650265

DOI: 10.1196/annals.1322.048

Other references

Hartenbaum, N.; Collop, N.; Rosen, I.; Phillips, B., 2006: Truckers with OSA, should they be driving?. Journal of Occupational and Environmental Medicine 48(9): 871-872

Massai, D., 1978: Report of a learning experience. Professioni Infermieristiche 31(4): 189-191

Ramaraj R.; Natarajan P., 1989: Photoelectrochemical investigations of phenosafranine dye bound to some macromolecules. Macromolecular-bound pehnosafranine dyes have been synthesized and characterized. The absorption spectra of the polymer-bound dyes show a bathochromic shift while the emission spectra shift slightly to higher frequency. Cyclic voltammetry of polym...

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Provan, J.L.; Moreau, P.; MacNab, I., 1979: Pitfalls in the diagnosis of leg pain. Problems may confront the practitioner in the diagnosis of leg pain related to exercise. The diagnostic features of the history and the physical examination that will help to elucidate the various causes of leg pain are outlined in this article, a...

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Clark, David B., 1996: Abolishing virginity. Journal of Tropical Ecology 12(5): 735-739

Wohlfart, G., 1952: Encephalopathy due to carbon monoxide poisoning; reply to Professor Kinberg. Svenska Lakartidningen 49(12): 779-786

Guevara V.F., 1967: Clearing technique for botanical materials. Philippine Agriculturist: 977-983

Smith, C., 1983: "Hands on": deferred giving: letting the donor have his cake while you eat it too. Foundation News 25(1): 22-31