geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

New treatment strategy of multiple myeloma for cure


, : New treatment strategy of multiple myeloma for cure. Gan to Kagaku Ryoho. Cancer & ChemoTherapy 33(4): 417-423

Multiple myeloma has long been considered an incurable disease. Indeed, the median survival time in patients treated with conventional chemotherapy has been reported to be about 3 years, and the survival rate decreased consecutively and was about 2 to 3% at 10 years. However, after introduction of autologous stem-cell transplantation in the 1990s, the median survival time was improved to about 5 years. Furthermore, novel drugs have been introduced in the treatment of patients with relapsed/refractory multiple myeloma, and improved the prognosis of these patients. Thalidomide, which has anti-angiogenetic activity, has a 30-40% response rate, and the combination of thalidomide and dexamethasone has a 40-50% response rate. Lenalidomide, which is a thalidomide analog, has a higher efficacy and lower incidence of adverse effects than thalidomide. Bortezomib, which is a proteasome inhibitor and inhibits NF-kappaB activity, has also excellent efficacy like thalidomide. The clinical trials using these drugs for newly diagnosed patients are now ongoing around the world, and show very excellent results. The good combination of stem-cell transplantation and novel drugs may well improve the prognosis of patients with multiple myeloma, and induce a cure,especially in young patients.

US$29.90

PMID: 16612147


Other references

Anonymous, 1994: British Association for Cancer Research and Association of Cancer Physicians annual meeting. Birmingham, 27-30 March 1994. Abstracts. British Journal of Cancer. Supplement 21: 1-68

Zandvoort, R., 1963: Reports on trials concerning the profitability of controlling Sitona lineata and Thrips angusticeps on peas (series 204) and Contarinia pisi (series 205), 1960.. In trials at 4 sites, plots of peas for seed were sprayed with 25% DDT emulsion at 2.4 1./ha or 25% para-thion emulsion at 1.6 l./ha as soon as the crop was attacked by either S. lineata or T. angusticeps. Some plots were re-sprayed 8-10 days late...

Greenwood, R.D., 1976: Early descriptions in medicine: obstetrical complications. Maryland State Medical Journal 25(5): 53-55

Uchida, H.; Uneyama, H.; Yoshimoto, R.; Inoue, K.; Akaike, N., 1998: Effects of cilnidipine, an antihypertensive drug, on the cardiac L-type and sympathetic N-type Ca2+ channel currents. Japanese Journal of Pharmacology 79(SUPPL 1): 202P

Mcknight R.O., 1969: Growth promoting activity of porcine growth hormone in chick embryos. American Zoologist: 1090

Soreide, E.; Reiestad, F.; Stromskag, K.E.; Hveberg, R.; Lange, O.J., 1990: Oral oxazepam vs. intramuscular morphine hyoscine for premedication a study of gastric content using fiber optic gastroscopy. In 40 patients scheduled for gynaecological surgery, premedication using oral oxazepam 50 mg, ingested with 100 ml of water, was compared with intramuscular morphine-hyoscine (scopolamine) 10 mg + 0.4 mg with respect to effects on gastric pH and v...

Paikoff, R.L., 1995: Early heterosexual debut: situations of sexual possibility during the transition to adolescence. Preadolescent sexuality among urban, minority youth is considered within a normative developmental context. Fourth- and fifth-grade children living in an urban, primarily African-American, low-income neighborhood were interviewed regarding situati...

Hernandez, E.H.; Castro, L.R., 2000: Larval growth of the anchoveta Engraulis ringens during the winter spawning season off central Chile. Larval growth rates of the anchoveta Engraulis ringens were determined for two periods during the winter spawning season off Talcahuano, central Chile. Because winter is the season of minimum plankton production during the year, we hypothesized th...

Mügge, A.; Lopez, J.A.; Piegors, D.J.; Breese, K.R.; Heistad, D.D., 1991: Acetylcholine-induced vasodilatation in rabbit hindlimb in vivo is not inhibited by analogues of L-arginine. Nitric oxide (NO) or related nitroso compounds are an endothelium-derived relaxing factor (EDRF), originating from metabolism of L-arginine, L-Arginine analogues with chemically altered guanidino moity are potent and specific inhibitors of EDRF(NO...

Nevzat, A., 1934: Gongylonema in Sheep and Cattle in Turkey. The author, who first reported G. sentatum in sheep in Turkey in 1922, has made a fuller study of its incidence and also of its morphology. Although he only found this species of the genus in sheep, he found what appears to be a new species in cat...