+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

No role for kaposi sarcoma-associated herpesvirus in pediatric idiopathic pulmonary hypertension

, : No role for kaposi sarcoma-associated herpesvirus in pediatric idiopathic pulmonary hypertension. Pediatric Pulmonology 41(2): 122-125

Idiopathic pulmonary hypertension (IPHT) is a rare but progressive disease with devastating outcomes, especially in children. The etiology is unknown. A recent study reported a potential role of Kaposi sarcoma-associated herpesvirus in the pathogenesis of IPHT in adults. Our goal was to test if this association exists in pediatric patients. The pathology specimen database of the Children's Hospital of Pittsburgh from 1980-2004 was searched, and all patients with a diagnosis of IPHT were enrolled. Lung tissues containing the characteristic plexiform lesion from all patients were selected and stained with antibody to latent nuclear antigen (LNA-1) of Kaposi sarcoma-associated herpesvirus. To avoid false-negative results, three different positive controls were utilized. Eighteen patients were identified; 3 had familial pulmonary hypertension, and 2 had persistent pulmonary hypertension of infancy. Patients' ages varied from 3 days to 17 years, and the female-to-male ratio was 2:1. No positive history of HIV or of parents with HIV was identified. The Heath-Edwards grade of pulmonary hypertension was between 3-5. All patients died: 11 from the disease, and the remaining 7 died after receiving a lung transplant. Immunohistochemical staining with LNA-1 antibody showed no staining of either endothelial or smooth muscle cell nuclei in any of the patients' lung tissues, while all three positive control specimens showed the characteristic intranuclear granular, punctate staining pattern. Our results do not support a role for Kaposi sarcoma-associated herpesvirus in the pathogenesis of pediatric IPHT.


PMID: 16369926

DOI: 10.1002/ppul.20349

Other references

Koberstein, R., 1988: Experience with a new glucose reflectometer in 14 diabetes centers. Medizinische Klinik 83(5): 164-167

Lichko R.P.; Builov V.V.; Steputina V.I., 1979: Rapid method for determining soil beta fructo furanosidase invertase activity. A mixture of 2-4 g of soil, 8-16 ml of 5% sucrose solution in phosphate buffer pH 4.8 and 0.5 ml of toluol was incubated for 2 h at C. Soil sterilized at served as a control. Enzymatic hydrolysis was stopped by boiling with...

Hass, F.J.; Haag, H.P., 1989: Correlation between leaf nutrient, aluminium and sodium concentrations in Coast Cross No.1 and physical and chemical analyses of a Typic Acrortox Soil. I. Leaf nutrient concentration as a function of the soil physical characteristics. Soil and leaf samples were collected from 41 distinct sites in a Cynodon dactylon cv. Coastcross 1 pasture growing on a red-yellow latosol at Jaguariuna, SW Sao Paulo. Leaf K concn was negatively correlated with soil silt content. Leaf Cu concn wa...

Gnudi, S.; Sitta, E., 2005: Clinical risk factor evaluation to defer postmenopausal women from bone mineral density measurement: an Italian study. To identify clinical risk factors (CRFs) best related to low bone mineral density (BMD) and to assess their abilityin deferring women from dual-energy X-ray absorptiometry (DXA), 1187 Italian postmenopausal women, dividedinto development (709) and...

Ponomar'kov, V.I.; Golubeva, V.A., 1986: Clinico-morphological analysis of spontaneous testicular tumors in dogs. The study of 83 cases of testicular tumours in dogs based on the International Histological Classification of tumours in domestic animals (WHO) has shown that these tumours can be divided into three groups: sex cord-stromal tumours (43.3%), germ c...

Bhanwra R.K.; Choda S.P.; Kumar R., 1985: Comparative embryology of brachiaria ramosa and poa annua. Anthers are tetrasporangiate. Anther wall comprises of four layers of cells. Meiosis in microspore mother cells is normal and successive cytokinesis leads to the formation of isobilateral microspore tetrads. The ovule is bitegmic, pseudocrassinuce...

Weber, M.L.; Ibrahim, H.N.; Lake, J.R., 2013: Renal dysfunction in liver transplant recipients: evaluation of the critical issues. Major progress has been made in the field of liver transplantation since the first procedure was performed nearly 50 years ago. Despite these improvements, renal dysfunction before and after liver transplantation remains a major complicating facto...

Binswanger, O., 1951: International Association of Hospitals; VIIth International Hospital Congress. Veska 15(2): 52-53

Blewett, D.A.; Watson, W.A., 1983: The epidemiology of ovine toxoplasmosis. II. Possible sources of infection in outbreaks of clinical disease. The effects of Toxoplasma infection on ewes at different stages of pregnancy, possible sources of infection, and patterns of exposure to infection are reviewed. It is concluded that clinical ovine toxoplasmosis is a result of primary infection dur...

Tamaoka, A., 2012: Alzheimer's disease: definition and National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association (NINCDS-ADRDA). Nihon Rinsho. Japanese Journal of Clinical Medicine 69 Suppl 10 Pt 2: 240-245