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Nucleic acids modulate autoimmunity through nucleic-acid-specific toll-like receptors

, : Nucleic acids modulate autoimmunity through nucleic-acid-specific toll-like receptors. Current Medicinal Chemistry 13(25): 3061-3067

Autoimmune diseases are believed to develop mainly from three factors comprising genetic predisposition, environmental factors and immune (dys-) regulation. In this context, specific nucleic acids of exogenous or endogenous origin that signal through nucleic acid-specific Toll-like receptors (TLRs) have gained much research attention. During ongoing autoimmune disease microbial nucleic acids contribute to flares of disease and its aggravation leading to end organ damage, through unfavourable immune modulation. Apart from exogenous sources, nucleic acid molecules of endogenous origin emerge as potential ligands for receptors of host defence, i.e. TLRs. Rapidly accumulating data on the role of nucleic acid-specific TLRs has not only provided insights about their pathogenic potential of endogenous nucleic acid molecules, but is also fuelling the development of novel immunotherapies.


PMID: 17073647

Other references

Finlay, J.B.; Hunter, J.A., 1971: Visualization of collagen cross-banding in the scanning electron microscope. Journal of Microscopy 93(3): 241-244

Miti, L.; Bronzini, R., 1959: Cycloserine therapy of tuberculosis. Minerva Medica 50(17): 602-606

Kraus, A.B.; Rohrer, F.; Grobler, E.S.; Ehhalt, D.H., 1996: The global tropospheric distribution of NOx estimated by a three-dimensional chemical tracer model. The global distribution of NOx in the troposphere is calculated using a simple three-dimensional chemical tracer model. This model includes a simplified chemistry scheme for the tracers NOx identical-to NO + NO2 and HNO3, which are redistributed b...

Cavazza L., 1981: Interpretation of the relationship between yield and plant population density. An improved equation is proposed to fit data from plant population density experiments. The equation is obtained by extending that of Holliday and others to cases where the yield declines after reaching a maximum corresponding to an optimum plant...

Rogers, D.H.; Elliott, R.L., 1989: Irrigation scheduling using crop growth simulation, risk analysis, and weather forecasts. Transactions of the ASAE 32: 69-77

Altinay, L.; Altinay, M., 2003: How will growth be financed by the international hotel companies?. This paper presents a set of secondary findings about the environmental factors influencing the international expansion plans of Bass Hotels and Resorts. Literature indicates that different factors in the business environment influence decisions o...

Pliss, G.B., 1978: Modern concepts of chemical carcinogenesis mechanisms. Circulation of carcinogens, their metabolic transformations and possible pathways of activation for carcinogens are among the topics discussed in this literature review. The role of benzo-(a)pyrene, 2-acetylaminofluorene and .beta.-glucuronidase i...

Goscombe B.; Gray D.; Hand M., 2005: Evidence for oblique, up-plunge extrusion in the core of a transpressional orogen. Contributions of the Economic Geology Research Unit 64: 176

Katahashi, T.; Kanda, T.; Konno, A., 1997: Distribution of choline acetyltransferase (ChAT) immunoreactive nerve fibers in the nasal mucosa; especially in the respiratory epithelium. The distribution and morphological construction of cholinergic nerve fibers in the respiratory nasal mucosa of the rat and human were investigated using choline acetyltransferase (ChAT) activities by means of light microscopy, confocal laser scann...

Querangal Des Essarts, S.; Autheman, 1946: Note sur trois cas de coccidiose humaine observes a Toulon dont un cas autochtone. Isospora belli was found in 3 patients with intestinal symptoms, 2 of whom had recently been in N. Africa, but one of whom had never been out of France. The Coccidia disappeared from the feces following treatment with quinacrine.