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Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency


, : Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency. Cochrane Database of Systematic Reviews (): Cd004655-Cd004655

Vitamin B12 deficiency is common and rises with age. Most people with vitamin B12 deficiency are treated in primary care with intramuscular vitamin B12 which is a considerable source of work for health care professionals. Several case control and case series studies have reported equal efficacy of oral administration of vitamin B12 but it is rarely prescribed in this form, other than in Sweden and Canada. Doctors may not be prescribing oral formulations because they are unaware of this option or have concerns regarding effectiveness. To assess the effectiveness of oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency. Searches were undertaken of The Cochrane Library, MEDLINE, EMBASE and Lilacs in early 2005. The bibliographies of all relevant papers identified using this strategy were searched. In addition we contacted authors of relevant identified studies and Vitamin B12 research and pharmaceutical companies to enquire about other published or unpublished studies and ongoing trials. Randomised controlled trials (RCTs) examining the use of oral or intramuscular vitamin B12 to treat vitamin B12 deficiency. All abstracts or titles identified by the electronic searches were independently scrutinised by two reviewers. When a difference between reviewers arose, we obtained and reviewed a hard copy of the papers and made decisions by consensus. We obtained a copy of all pre-selected papers and two researchers independently extracted the data from these studies using piloted data extraction forms. The whole group checked whether inclusion and exclusion criteria were met, and disagreement was decided by consensus. The methodological quality of the included studies was independently assessed by two researchers and disagreements were brought back to the whole group and resolved by consensus. Two RCT's comparing oral with intramuscular administration of vitamin B12 met our inclusion criteria. The trials recruited a total of 108 participants and followed up 93 of these from 90 days to four months. High oral doses of B12 (1000 mcg and 2000 mcg) were as effective as intramuscular administration in achieving haematological and neurological responses. The evidence derived from these limited studies suggests that 2000 mcg doses of oral vitamin B12 daily and 1000 mcg doses initially daily and thereafter weekly and then monthly may be as effective as intramuscular administration in obtaining short term haematological and neurological responses in vitamin B12 deficient patients.

US$19.90

PMID: 16034940

DOI: 10.1002/14651858.CD004655.pub2


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Jin, H.; Yoshitake, H.; Tsukamoto, H.; Takahashi, M.; Mori, M.; Takizawa, T.; Takamori, K.; Ogawa, H.; Kinoshita, K.; Araki, Y., 2006: Molecular characterization of a germ-cell-specific antigen, TEX101, from mouse testis. TEX101, a glycoprotein we recently identified, is primarily characterized as a unique germ-cell-specific marker protein that shows sexually dimorphic expression during mouse gonad development. Based on data obtained from molecular biological as we...

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Thompson, K.Evan.; Wang, Y.; Madej, T.; Bryant, S.H., 2009: Improving protein structure similarity searches using domain boundaries based on conserved sequence information. The identification of protein domains plays an important role in protein structure comparison. Domain query size and composition are critical to structure similarity search algorithms such as the Vector Alignment Search Tool (VAST), the method emp...

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Von Drehle, D., 2008: Death penalty walking. Time 171(2): 38-41

Colman, R.W.; Schreiber, A.D., 1976: Effect of heterologous antibody on human platelets. The effect of heterologous anti-human platelet antibody on human platelet function was examined in the presence and absence of whole plasma as an in vitro model for antibody-induced immune damage to cells. Heterologous IgG [immunoglobulin G] anti-...

Schrangl, H., 1977: Prevention is better than crying. Osterreichische Zahnarzts-Zeitung; Mitteilungen der Bundesfachgruppe für Zahnheilkunde der Osterreichischen Arztekammer 28(10): 377-379

Foster, C.B.; Choi, E.H.a; Chanock, S.J., 2000: Adenovirus and marrow transplantation in children. Adenovirus disease is a major cause of morbidity and mortality among recipients of marrow transplants. Recent advances have contributed to a finer understanding of the biological basis for viral persistence in the normal host as well as disseminat...

Ellison, P.T., 1994: Advances in human reproductive ecology. Human reproductive ecology pertains to reproduction biology and changes due to environmental influences. The research literature relies on clinical, epidemiological, and demographic analysis. The emphasis is on normal, nonpathological states and a...

Zhang, X.; Hu, C.; Li, Y.; Wang, J.; Li, Y., 2007: Correlation of integrin β1 mRNA and integrin β3 mRNA expression with microvascular density and biological behaviour of squamous cell carcinoma of the lung. It has been proven that the newborn vessels and adhesion ability are very important characters of malignant tumor cells. Among all the invasion and metastasis factors, integrins seem to be hot spots gradually because of their special construction...