geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Pharmaceutical aspects of hemoglobin-based oxygen carriers


, : Pharmaceutical aspects of hemoglobin-based oxygen carriers. Current Drug Delivery 2(2): 133-142

Oxygen delivery has evolved as a therapy of widespread interest in the clinical setting, especially in emergency medicine and anesthesiology. With the widespread recognition of blood-borne infections during the last two decades and the looming shortage of donor blood in future, efforts to formulate an artificial substitute for oxygen carrying capacity of RBCs have increased. Such blood substitutes, defined more correctly as oxygen therapeutics, are particularly valuable in circumstances such as war and trauma situations where properly matched blood may not be immediately available or is not accepted by the recipients for religious reasons. Several elegant formulations of hemoglobin, both free and encapsulated, have evolved recently and are collectively referred to as hemoglobin-based oxygen carriers (HBOCs). Few HBOCs have successfully entered into the clinical phase. This review discusses formulation requirements of HBOCs from a physiological viewpoint. Physico-pharmaceutical parameters, such as colloidal oncotic pressure, osmolality, viscosity, sterility, apyrogenicity and shelf-stability are traditionally a concern for large volume parenterals meant for resuscitation purposes. At the same time, properties such as oxygen affinity, hemoglobin content and in vivo efficacy of oxygen carriers are specific to HBOCs. Owing to the presence of a very active and functional protein (hemoglobin), requirements for adequate performance of HBOCs significantly differ from those of other large-volume parenterals, such as lactated Ringer's solution, and plasma expanders, such as dextran or albumin solutions.

US$29.90

PMID: 16305414


Other references

Dieci, G.; Sentenac, A., 1996: Facilitated recycling pathway for RNA polymerase III. We show that the high in vitro transcription efficiency of yeast RNA pol III is mainly due to rapid recycling. Kinetic analysis shows that RNA polymerase recycling on preassembled tDNA cntdot TFIIIC cntdot TFIIIB complexes is much faster than the...

Mallik D.K., 1992: Preliminary feasibility stage investigation on the proposed bridge (III) across Katri Nala at km 8.3 on Lohpiti-Sindri Road, District Dhanbad, Bihar. Records of the Geological Survey of India 125, Part 3: 130

Szyfres, B., 1964: Present-Day Aspects And Experimentation In The Prophylaxis Of Brucellosis. Revista de la Asociacion Medica Argentina 78: 251-256

Krongrad A.; Droller M.J., 1989: Zinc and the prostate. Paulson, D F (Ed ) Prostatic Disorders Xiv+383p Lea And Febiger: Philadelphia, Pennsylvania, Usa; London, England, Uk Illus 107-124

Bhana, K., 1985: A developmental analysis of indian children's perceptions of control in the different domains of school functioning. Indian children's perceptions of control in the cognitive, social and physical domains of school functioning were assessed by means of the 'Multidimensional measure of children's perceptions of control' developed by Connell (19...

Mestres, C.A.; Igual, A.; Ugolini, A.L.; Cubells, J.; Espinosa, M.; Petit, M.; Murtra, M., 1982: Surgical treatment of lesions of the common trunk of the left coronary artery. Revista Espanola de Cardiologia 35(6): 519-523

Gooneratne, I.K.; Gamage, R.; Gunarathne, K.S., 2010: Internal carotid artery dissection: an unusual cause of occipital infarction. Annals of Indian Academy of Neurology 13(2): 148-149

Carmonagomez, R.; Berria, M.I., 1964: Comparative Study Of Intestinal Flora In Healthy, Diseased And Individuals Clinically Cured Of Epidemic Diarrhea. 1. Clinical Study. 2. Bacteriological Typing. 3. Parasitological Study. 4. General Conclusions. Revista de la Asociacion Medica Argentina 78: 649-659

Tanenbaum, L.; Parrish, J.A.; Haynes, H.A.; Fitzpatrick, T.B.; Pathak, M.A., 1976: Prolonged uv light induced erythema and the cutaneous carcinoma phenotype. A considerable amount of evidence exists in support of the role of UV radiation as a major etiologic factor in human skin cancer, melanoma and carcinoma types. On the basis of epidemiologic studies a phenotype was described which helps to identify...

Yang, T.F.; Macfarlane, P.W., 1994: Normal limits of the derived vectorcardiogram in Caucasians. The derived vectorcardiogram (dVCG) can be obtained from three orthogonal leads X, Y, Z, which are synthesized from the conventional 12-lead ECG by one of a number of mathematical techniques. The application of the dVCG in routine cardiological pr...