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Phase II trial of postoperative adjuvant paclitaxel/carboplatin and thoracic radiotherapy in resected stage II and IIIA non-small-cell lung cancer: promising long-term results of the Radiation Therapy Oncology Group--RTOG 9705


, : Phase II trial of postoperative adjuvant paclitaxel/carboplatin and thoracic radiotherapy in resected stage II and IIIA non-small-cell lung cancer: promising long-term results of the Radiation Therapy Oncology Group--RTOG 9705. Journal of Clinical Oncology 23(15): 3480-3487

To determine the overall survival, progression-free survival, and toxicity associated with concurrent paclitaxel/carboplatin and thoracic radiotherapy for completely resected patients with stage II and IIIA non-small-cell lung cancer (NSCLC). Eighty-eight eligible patients had surgical resection for pathologic stage II or IIIA disease and received postoperative paclitaxel and carboplatin. Concurrent thoracic radiotherapy at 50.4 Gy in 28 fractions for 6 weeks (1.8 Gy/d, 5 days/wk) was given during cycles 1 and 2. A boost of 10.8 Gy in six fractions was given for extracapsular nodal extension or T3 lesions. Treatment compliance was acceptable, with 93% compliance for radiation therapy and 86% for chemotherapy completion. The median duration of follow-up was 56.7 months (range, 17 to 61 months). The median overall survival time was 56.3 months, with 1-, 2-, and 3-year survival rates of 86%, 70%, and 61%, respectively. The 1-, 2-, and 3- year progression-free survival rates were 70%, 57%, and 50%, respectively. Brain metastasis occurred as the sole site of first failure in 11%, and 9% failed in other metastatic sites as first failure. Of the 43 patients who died, the cause of death was the treated cancer in 31 (35%). Local failure was a component of first failure in 15% of patients. Toxicities were acceptable. An overall survival comparison to Eastern Cooperative Oncology Group 3590 is favorable. The mature results of this trial suggest an improved overall and progression-free survival in this group of resected NSCLC patients, compared with previously reported trials. A phase III trial comparing this treatment regimen with standard therapy seems warranted.

US$19.90

PMID: 15908657

DOI: 10.1200/JCO.2005.12.120


Other references

Ioannou, C.I.; Furuya, S.; Altenmüller, E., 2016: Objective Evaluation of Performance Stress in Musicians With Focal Hand Dystonia: A Case Series. NlmCategory="UNASSIGNED">Five musicians suffering from focal dystonia participated in a pilot study that examined the feasibility of an experimental protocol designed to assess musicians' motor performance under stress. Electroca...

Enzell C.R.; Francis G.W.; Liaaen Jensen S., 1968: Inst mass spectrometric studies of carotenoids i occurrence and intensity ratios of m 92 and m 106 peaks. Acta Chemica Scandinavica 22(3): 1054-1055

Lefort, A.; Gepner, P.; Cordoliani, F.; Piette, A.M.; Cosserat, J.; Bletry, O.; Chapman, A., 1994: Is Kawasaki disease parvovirus B19 related?. Arthritis & Rheumatism 37(9 SUPPL ): S237

Kubota, K.; Tsuchiya, K.; Onuki, T.; Arai, J.; Sugino, N.; Nihei, H., 1995: Functional approach to the mechanism of cystogenesis in experimental cystic disease. Journal of the American Society of Nephrology 6(3): 700

Kolin, A.; Norris, J.W., 1984: Myocardial damage from acute cerebral lesions. Autopsy findings in 58 patients with intracranial lesions were compared with those in 50 control patients for myocardial damage, characterised by a change from a myofibrillar to a granular staining pattern, using a histochemical method for succini...

Lu, Y.; Sweiss, N.J., 2016: MRI and FDG PET/CT imaging manifestations of cardiac sarcoidosis. A 52-year-old man had biopsy-proven sarcoidosis of mediastinal lymph nodes. Cardiac sarcoidosis was confirmed on cardiac MRI with typical imaging features as delayed gadolinium enhancement. Follow-up FDG PET/CT with a 3-day pretest diet modificati...

Osborne, L.C.; WegenerParfrey, L., 2016: Liver Flukes and the Microbiota in Cancer. Ebiomedicine 8: 12-13

Petrov B.V.; Suprunenko E.I., 1991: Geological and geophysical zoning and depth structure of the Vetrenyy Poyas Zone. Pages 43-52:

Czeizel, E., 1999: Primary prevention of developmental abnormalities. Orvosi Hetilap 140(13): 739-741

Sheikh Omar A.R.; Abdullah M.N.; Mohna S.S., 1989: An observation on gastric ulceration in porkers. Jurnal Veterinar Malaysia 1(1): 65-66