geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Physicochemical characterization and dissolution enhancement of aceclofenac-hydroxypropyl beta-cyclodextrin binary systems


, : Physicochemical characterization and dissolution enhancement of aceclofenac-hydroxypropyl beta-cyclodextrin binary systems. Pda Journal of Pharmaceutical Science and Technology 60(6): 378-388

The aim of this study is to prepare and characterize binary systems of aceclofenac (AC) with hydroxypropyl beta-cyclodextrin (HPbetaCD) in equimolar ratio. Solid binary systems of aceclofenac with HPbetaCD were prepared using cogrinding, kneading, and coevaporating methods, and a physical mixture was prepared for comparison. The binary systems were characterized by differential scanning calorimetry, thermogravimetric analysis, mass spectroscopy, 1H nuclear magnetic resonance (NMR) spectroscopy, scanning electron microscopy, and in vitro dissolution studies. 1H NMR studies showed that AC partially fits into the HPbetaCD torus cavity with a preferential inclusion of the phenyl ring of the drug. All the binary systems showed superior dissolution and lower dose:solubility ratio (D:S ratio) as compared to pure AC, but the kneaded product exhibited the best dissolution, with complete drug release within 10 min and a D:S ratio of 5 mL. Hence, it was suggested that complexation of aceclofenac with HPbetaCD may be used as an approach to change the drug from Biopharmaceutics Classification System BCS Class II to BCS Class I without changing its intrinsic permeability.

US$29.90

PMID: 17260903


Other references

Kitaguchi, K.; Hanamura, N.; Murata, M.; Hashimoto, M.; Tsukagoshi, K., 2015: Tube radial distribution phenomenon with a two-phase separation solution of a fluorocarbon and hydrocarbon organic solvent mixture in a capillary tube and metal compounds separation. A fluorocarbon and hydrocarbon organic solvent mixture is known as a temperature-induced phase-separation solution. When a mixed solution of tetradecafluorohexane as a fluorocarbon organic solvent and hexane as a hydrocarbon organic solvent (e.g.,...

Svartman, M.; Almeida, E.-Judith-Cardoso-De, 1992: The karyotype of Oryzomys capito laticeps (Cricetidae, Rodentia) from Central Brazil. Cytogenetical data, including G-, C-, R-bands and NORs of Oryzomys capito laticeps (2n = 54; FN = 62) captured in Central Brazil are presented. The karyotype described in this paper is compared with those of other O. capito specimens.

Jickells, S.; Jones, N., 2003: Preliminary studies on the lipid chemistry of individual fingerprints and changes with time. Forensic Science International 136(Suppl 1): 131, September

Delamerens, S.; Tuttle, A.H.; Aballi, A.J., 1964: Neonatal Bilirubin Levels After Use Of Phenothiazine Derivatives For Obstetrical Analgesia. Journal of Pediatrics 65: 925-928

Singer, M., 2011: Oesophageal Doppler monitoring: should it be routine for high-risk surgical patients?. To determine whether sufficient evidence exists to justify routine use of oesophageal Doppler monitoring to guide perioperative haemodynamic management in high-risk surgery. Systematic reviews of the literature have been performed independently by...

Skuterud, R., 1975: Tolerance of spring sown cereals to phenoxy acids. Several phenoxy acid herbicides were evaluated in wheat in 3 pot culture experiments during the summer of 1973. In the first experiment with oats cv. Titus, dichlorprop at 1 and 2 kg/ha applied at the 2- to 3-leaf stage reduced the d.m. yield of t...

Aneja, J.; Basu, D.; Mattoo, S.Kumar.; Kohli, K.Kumar., 2013: Metabolic syndrome in alcohol-dependent men: a cross-sectional study. In the context to mental illness metabolic syndrome (MS) has gained significant attention in the last decade. The present research aimed to study the prevalence of MS and its correlates among the alcohol-dependent men at a deaddiction center in No...

Monteyne, T.; Vancoillie, J.; Remon, J-Paul.; Vervaet, C.; D.B.er, T., 2016: Continuous melt granulation: Influence of process and formulation parameters upon granule and tablet properties. The pharmaceutical industry has a growing interest in alternative manufacturing models allowing automation and continuous production in order to improve process efficiency and reduce costs. Implementing a switch from batch to continuous processing...

Zorio, E.; Medina, P.; Rueda, J.; Millán, J.M.; Arnau, M.A.; Beneyto, M.; Marín, F.; Gimeno, J.R.; Osca, J.; Salvador, A.; España, F.; Estellés, A., 2009: Insights into the role of microRNAs in cardiac diseases: from biological signalling to therapeutic targets. microRNAs have recently opened new pathways to explain gene expression and disease biology in many scenarios, including cardiac diseases. microRNAs are endogenous small non-coding RNAs that mediate post-transcriptional repression or messenger RNA...

Schils, R.S.ijders, P., 2004: The combined effect of fertiliser nitrogen and phosphorus on herbage yield and changes in soil nutrients of a grass. Nutrient cycling in agroecosystems 68(2): 165-179