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Pilot evaluation of mirtazapine for the treatment of hot flashes

, : Pilot evaluation of mirtazapine for the treatment of hot flashes. Journal of Supportive Oncology 2(1): 50-56

This prospective, single-arm, pilot clinical trial, developed to evaluate the efficacy and tolerability of mirtazapine for alleviating hot flashes, was conducted between May 2001 and January 2002. Patients' baseline characteristics were collected during the first week of the study. At the beginning of the second week, patients were started on mirtazapine at a dose of 7.5 mg at bedtime. The dose of mirtazapine was then increased to 15 mg at week 3 and to 30 mg at week 4. For week 5, patients could choose whether to take 15 mg/d or 30 mg/d. Data were obtained primarily from patient-completed questionnaires. Data from 22 evaluable women were available. For the 16 patients who completed the study, the median reductions in total daily hot flashes and weekly hot-flash scores from their baselines were 52.5% and 59.5%, respectively. Patients reported improvements in tension, trouble sleeping, abnormal sweating, distress from hot flashes, satisfaction with hot-flash control, overall quality of life, and impact of hot flashes on quality of life. Patients also reported increases in appetite and dry mouth. Although data from a double-blind, placebo-controlled clinical trial would be necessary to more definitively elucidate the efficacy and toxicity of mirtazapine in patients with hot flashes, the available data suggest that mirtazapine is a reasonable treatment to consider in patients with hot flashes, particularly in those with anxiety and sleep disturbances.


PMID: 15330372

Other references

Somov V.I., 1980: The structure of the principal boundaries of the Earth's crust and geophysical fields; Recent movement of the Earth's crust. Pages 139-146:

Fraser, G.E.; Phillips, R.L.; Beeson, W.L., 1990: Hypertension, antihypertensive medication and risk of renal carcinoma in California Seventh-Day Adventists. A longitudinal study of 34 198 non-Hispanic white California Seventh-day Adventists identified incident cases of renal carcinoma over six years of follow-up. The use of antihypertensive medications and self-reported hypertension had estimated age-...

Clark B.; Mobbs P., 1990: A flat mount preparation of the rabbit retina for whole cell patch clamp studies of capillary endothelial cells pericytes and astrocytes. Journal of Physiology (Cambridge) 426: 7P

Wyatt D.F.J.; Jacobson L.A., 1993: Logging experience with the pulsed spectral gamma tool. Proceedings - Middle East Oil Show 8: II

O'Goshi, K.I.; Aoyama, H.; Tagami, H., 1998: Mucin deposition in a prayer nodule on the forehead. Dermatology 196(3): 364-364

Schettler, G., 1978: Medical education is missing its purpose and aims. Mmw, Munchener Medizinische Wochenschrift 120(42): 1360-1362

Zillig, H., 1922: The First and Second Generations of the Vine Moths. In the Rhine and Moselle districts in 1921 there was a very severe outbreak of the first generation of the vine-moths, Clysia (Conchylis) ambignella, Hb., and Polychrosis botrana, Schiff. In the areas where C. ambiguella occurred the second genera...

Bavier, A.R., 2016: Faculty Role: A Choice of Styles. Nursing Education Perspectives 37(2): 59-59

Dumanskiy S.G.; Kul chitskiy D.I., 1965: Regularities of temperature anomalies of the oil and and gas fields of ciscarpathia and transcarpathia. Ukrainskiy Nauchno-Issledovatel'skii Geologorazvedochnyy Institut, Trudy 10: 117-122

Krutsay, M., 1959: Solitary plasmacytoma of the skin. Oncologia 12: 227-232