+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Platinum-based versus non-platinum-based chemotherapy in advanced non-small-cell lung cancer: a meta-analysis of the published literature

, : Platinum-based versus non-platinum-based chemotherapy in advanced non-small-cell lung cancer: a meta-analysis of the published literature. Journal of Clinical Oncology 23(13): 2926-2936

This meta-analysis was performed to compare the activity, efficacy and toxicity of platinum-based versus non-platinum-based chemotherapy in patients with advanced non-small-cell lung cancer. Randomized phase II and III clinical trials comparing first-line palliative platinum-based chemotherapy with the same regimen without platinum or with platinum replaced by a nonplatinum agent were identified by electronic searches of Medline, Embase, and Cancerlit, and hand searches of relevant abstract books and reference lists. Response rates, 1-year survival, and toxicity were analyzed. Subgroups of trials using third-generation agents were compared. Thirty-seven assessable trials were identified including 7,633 patients. A 62% increase in the odds ratio (OR) for response was attributable to platinum-based therapy (OR, 1.62; 95% CI, 1.46 to 1.8; P < .0001). The 1-year survival rate was increased by 5% with platinum-based regimens (34% v 29%; OR, 1.21; 95% CI, 1.09 to 1.35; P = .0003). No statistically significant increase in 1-year survival was found when platinum therapies were compared to third-generation-based combination regimens (OR, 1.11; 95% CI, 0.96 to 1.28; P = .17). The toxicity of platinum-based regimens was significantly higher for hematologic toxicity, nephrotoxicity, and nausea and vomiting, but not for neurotoxicity, febrile neutropenia rate, or toxic death rate. Response is significantly higher with platinum-containing regimens. One-year survival was not significantly prolonged when platinum-based therapies were compared with third-generation-based combination regimens. Toxicity is generally higher for platinum-based regimens.


PMID: 15728229

DOI: 10.1200/JCO.2005.03.045

Other references

Anastassopoulos, G.; Rama, R., 2005: The performance of multinational agribusinesses: effects of product and geographical diversification. This chapter studies the impact of geographical and industrial diversification on the growth rates of the world's 100 largest food and drink multinational companies, using panel data covering 1985-96. Results indicate, among others, that: rel...

Le, H.; Singh, S.; Shih, S-Jen.; Du, N.; Schnyder, S.; Loredo, G.A.; Bien, C.; Michaelis, L.; Toor, A.; Diaz, M.O.; Vaughan, A.T., 2009: Rearrangements of the MLL gene are influenced by DNA secondary structure, potentially mediated by topoisomerase II binding. The location of MLL translocation breakpoints within therapy-related acute myeloid leukemia linked to drugs targeting Topoisomerase II and infant acute leukemia (IAL) are biased toward the intron 11-exon 12 region of MLL, although lacking a compre...

Ruppert, H., 1956: Sex education from the gynecologist's point of view. Zeitschrift für Arztliche Fortbildung 50(1-2): 62-64

Busch, M., 1964: The Significance Of The Penumbra For Smaller Quadratic And Circular Irradiation Fields. Strahlentherapie 123: 373-380

Desselberger, U.; Georgii, A.; Zobl, H.; Ostertag, H., 1972: On the oncogenic activity of polyoma virus in the rat. Zentralblatt für Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe A: Medizinische Mikrobiologie und Parasitologie 219(1): 28-38

Ferrari, R.; Ceconi, C.; Campo, G.; Cangiano, E.; Cavazza, C.; Secchiero, P.; Tavazzi, L., 2010: Mechanisms of remodelling: a question of life (stem cell production) and death (myocyte apoptosis). Remodeling myocytes show a typical switch between the embryonic and classical features of apoptosis and/or hypertrophy representing a signal of death (ie, apoptosis) and a signal of life (ie, hypertrophy). The adult myocyte, however, is a terminal...

Mesiats, Vk, 1977: The goals of agricultural agencies and scientific and higher educational institutions in carrying out the regulation of the Central Committee of the Communist Party and USSR Council of Ministers On measures for further increasing the effectiveness of agricultural science and strengthening its relationship with farming practice. Vestnik sel'skokhoziaistvennoi nauki: (5) 4-20

Rand, C.S.; Macgregor, A.; Hankins, G., 1986: Gastric bypass surgery for obesity: weight loss, psychosocial outcome, and morbidity one and three years later. In two nonoverlapping cohorts of consecutive patients receiving gastric bypass for obesity, we interviewed 100 patients one year after operation and 60 patients at three years. Weight loss among patients in both cohorts averaged 45 kg; all had imp...

Kolberg, A., 1956: Altered influence of acetate on excretion of paraaminohippurate in hypertrophic renal tubular epithelium; preliminary report. Acta Medica Scandinavica 153(4): 315-318

Foucaud, C.; Poolman, B., 1992: Lactose transport system of Streptococcus thermophilus. Functional reconstitution of the protein and characterization of the kinetic mechanism of transport. The kinetic mechanism of the lactose transport system of Streptococcus thermophilus was studied in membrane vesicles fused with cytochrome c oxidase containing liposomes and in proteoliposomes in which cytochrome c oxidase was coreconstituted with...