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Preoperative serum fibrinogen level predicts postoperative pulmonary complications after lung cancer resection


, : Preoperative serum fibrinogen level predicts postoperative pulmonary complications after lung cancer resection. Annals of Thoracic Surgery 81(6): 1974-1981

Patients undergoing pulmonary resection are thought to be at high risk for the development of postoperative pulmonary complications (PPCs), and these complications may lead to serious morbidity. The purpose of this study was to identify the factors associated with postoperative pulmonary complications in patients undergoing lung cancer resection and to determine the effect of PPCs on survival. The study involved a retrospective review of 635 patients who had undergone curative resection for lung cancer. The patient group included 504 males (79.4%), and the overall mean age was 61.3 years. Patients were classified as those who had experienced PPCs (PPCs group, n = 105, 16.5%) or those who had not (no-PPCs group, n = 530, 83.5%). The surgical procedures performed were 101 pneumonectomies (15.9%), 505 lobectomies (79.5%), and 29 lesser resections (4.6%). Cancer types comprised 330 squamous cell carcinomas (52.0%), 255 adenocarcinomas (40.2%) and 50 others (7.8%). Univariate analysis showed that the following factors were predictors for PPCs: male sex, erythrocyte sedimentation rate, preoperative serum fibrinogen level, pulmonary function, chronic obstructive pulmonary disease, smoking, double primary cancer, and surgical duration. Multivariate logistic regression showed that preoperative serum fibrinogen level (p < 0.001), surgical duration (p < 0.0001) and being male (p = 0.02) were significant predictors of PPCs. Overall survival 3 years after surgery was 68.2% in no-PPCs group and 38.8% in PPCs group (p < 0.0001). Regardless of tumor staging, overall survival differed significantly between PPCs and no-PPCs groups, whereas disease-free survival did not. Higher preoperative serum fibrinogen levels, longer surgical duration, and being male were the predictive factors for PPCs in surgical candidates. The development of PPCs was linked to a shortened overall survival.

US$19.90

PMID: 16731116

DOI: 10.1016/j.athoracsur.2006.01.032


Other references

Mitchell, J.C., 1960: Opening of Strickland Lodge, Umtau. Central African Journal of Medicine 6: 541-542

Lenzerini L.; Meera Khan P.; Filippi G.; Rattazzi M.C.; Ray A.K.; Siniscalco M., 1969: Characterization of enz glucose 6 phosphate dehydrogenase variants occurrence of a enz glucose 6 phosphate seattle like variant in sardinia and its interaction with the enz glucose 6 phosphate dehydrogenase mediterranean variant human. American Journal of Human Genetics 21(2): 142-153

Dynowska M., 1988: Variability of sclerotia in some species of genus typhula. On the basis of Typhula incarnata Lasch ex. Fr., Typhula phacorrhiza Fr. and Typhula variabilis Riess. sclerotia morphology comparison the dependence of their structure upon the conditions in which they come into existence has been found. The scle...

Boulaine J., 1982: Epistemologic problems of soil classification. Memoires Geologiques de l'Universite de Dijon 7: 119-127

Kimura, Y.; Morita, T.; Hayashi, K'ichiro.; Miki, T.; Sobue, K., 2010: Myocardin functions as an effective inducer of growth arrest and differentiation in human uterine leiomyosarcoma cells. Myocardin is an important transcriptional regulator in smooth and cardiac muscle development. We noticed that the expression of myocardin was markedly downregulated in human uterine leiomyosarcoma cells. Restoration of myocardin expression induced...

Bower Margaret M., 1962: The cause of erosion in blanket peat bogs; a review of evidence in the light of recent work in the Pennines. Severe erosion of blanket peat now taking place in the Pennines and other areas in Great Britain probably reflects the fact that blanket peat bogs of northern upland regions constitute inherently unstable systems, in which erosion is the natural e...

Takenaka, M.; Imamura, T.; Nojima, T.; Takegami, T., 2001: Extraction of RNA from paraffin embedded tissues and analysis of p53 gene expression in colonic cancer. We examined, immunohistochemically and molecular biologically, p53 gene expression in 10 patients with colonic cancer. RNA was extracted from paraffin embedded normal and colonic cancer tissues by using RNA isolator kit and proteinase K. The most...

Farriaux, J.P., 1996: Absent pediatrician or pediatrician as conductor of an orchestra. Archives de Pediatrie 3 Suppl 1: 32s-33s

Wei Chongtao; Qin Yong; Wang Geoff G.X.; F.X.ehai; Jiang Bo; Zhang Zhiqing, 2007: Simulation study on evolution of coalbed methane reservoir in Qinshui Basin, China. A dynamic equilibrium model has been proposed to describe the coalbed methane concentration-dissipation evolution process in coal, including its generation, storage and migration. The model, developed with a computational program, has been applied...

Jensen, P.R.; Fenical, W., 2002: Secondary metabolites from marine fungi. Hyde, Kevin D [Editor, Reprint Author] Fungi in marine environments : 293-315