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Prevention by adrenal-regeneration hypertension by an aldosterone-blocker

, : Prevention by adrenal-regeneration hypertension by an aldosterone-blocker. Endocrinology 64(2): 299-300

Chronic treatment of rats with the aldosterone-blocker 3-(3-oxo-17[beta]-hydroxy-4-androsten-17[alpha]-yl) propionic acid gamma-lactone prevented adrenal-regeneration hypertension and the accompanying cardiac hypertrophy. Unaffected were: mortality, body weight, saline intake, renal and adrenal hypertrophy.


PMID: 13619588

DOI: 10.1210/endo-64-2-299

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