geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Prognostic value of the atrial systolic mitral annular motion velocity in patients with left ventricular systolic dysfunction


, : Prognostic value of the atrial systolic mitral annular motion velocity in patients with left ventricular systolic dysfunction. Journal of the American Society of Echocardiography 16(4): 333-339

Transmitral flow velocity variables are powerful predictors of poor prognosis in patients with left ventricular (LV) systolic dysfunction. However, these variables may not accurately reflect the severity of pulmonary congestion. This study was designed to determine whether the peak atrial systolic mitral annular motion velocity (MA-Aw) measured by pulsed Doppler tissue imaging can predict cardiac death or hospitalization for worsening heart failure in patients with LV systolic dysfunction. MA-Aw was recorded in 96 patients with LV systolic dysfunction who were followed up for 29 +/- 10 months. All patients underwent Doppler echocardiography on entry into the study, and cardiac catheterization was performed in 45 patients. Patients were divided into 3 groups on the basis of the ratio of early (E) to late (A) diastolic filling (E/A) of the transmitral flow velocity: group 1 (n=31; E/A < 1); group 2 (n=37; 1 < or = E/A < 2); and group 3 (n=28; E/A > or = 2). During follow-up, 36 patients (38%) died of cardiac causes and 34 (35%) were hospitalized for worsening heart failure. There were 2 cardiac deaths (6%) in group 1, 14 (39%) in group 2, and 20 (56%) in group 3. The MA-Aw correlated closely with the mean pulmonary capillary wedge pressure. Univariate Cox model analysis showed that MA-Aw < or = 5 cm/s was the most powerful predictor of cardiac death or hospitalization for worsening heart failure compared with clinical, hemodynamic, and the other echocardiographic variables. Furthermore, MA-Aw < or = 5 cm/s was clearly discernible as a good predictor of cardiac mortality on multivariate Cox model and as assessed by Kaplan-Meier method. The MA-Aw obtained by pulsed Doppler tissue imaging is a sensitive index of pulmonary congestion in patients with LV systolic dysfunction. It is a simple and noninvasive outcome measure and can be used to monitor treatment.

US$29.90

PMID: 12712015


Other references

Bhakta, T.; Mandal, S.C.; Sanghamitra Sinha; Saha, B.P.; Pal, M., 2001: Evaluation of antipyretic potential of Cassia fistula bud extract. The antipyretic potential of Cassia fistula (collected from Agartala, Tripura, India), commonly known as Sundali, has been evaluated on the basis of its traditional uses and literature references. Methanol extract of buds of C. fistula was examine...

Pellmyr O., 1987: Temporal patterns of ovule allocation fruit set and seed predation in anemonopsis macrophylla ranunculaceae. Ovule deployment patterns were studied in Anemonopsis macrophylla Sieb, and Zucc. to develop hypotheses about major selective forces underlying different temporal strategies. Carpel number per flower decreased significantly with relative flowering...

Zhang, H.Q.; Lou, H.Z., 1980: The inherited sterility of the European corn borer Ostrinia nubilalis (Hubnen). In studies in China, normal females of Ostrinia nubilalis (Hb.) that had mated with males exposed to gamma -radiation from 60Co at a partial sterilising dose of 20-25 krad produced F1 larvae that exhibited delayed development, increased mortality...

Banks-Smith, J.; Dowswell, T.; Gillam, S.; Shipman, C., 2002: Primary care groups and trusts. Nursing Times 97(45): 30-32

Dombrovskaia, I.F.; Molchanov, V.I., 1959: Life and creative activity of Vasilii Ivanovich Molchanov, member of the USSR Academy of Medical Sciences and honored scientist. Pediatriia 14(1): 3-4

Schiffer, C.A., 2008: Molecular characterization of AML: a significant advance or just another prognostic factor?. Although there have been several major laboratory advances which have been helpful diagnostically and in the general classification of risk groups, they have not resulted in improvement in the overall outcome for patients with AML and, with occasi...

Graber, J.H., 2003: Variations in yeast 3'-processing cis-elements correlate with transcript stability. A large set of yeast mRNA 3'-processing regulatory sequences was analyzed statistically, revealing a systematic variation that correlates with measured mRNA stability. Transcripts with relatively short half-lives have a high frequency of incl...

Tachibana, Y., 1971: Position of the median points of the face to the glabella-pogonion plane in Kumamoto inhabitants. Kumamoto Igakkai Zasshi. Journal of the Kumamoto Medical Society 45(8): 793-806

Anonymous, 1997: To clone a sheep. Washington Post: A18-A18

von Kettler, J.; Glenig, W.R., 1978: Bilateral chronic disk-shaped macula edema with microaneurysms, diffuse vasculitis and cystic degeneration of the retina. Bericht Uber die Zusammenkunft. Deutsche Ophthalmologische Gesellschaft: 610-618