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Prognostic value of the atrial systolic mitral annular motion velocity in patients with left ventricular systolic dysfunction

, : Prognostic value of the atrial systolic mitral annular motion velocity in patients with left ventricular systolic dysfunction. Journal of the American Society of Echocardiography 16(4): 333-339

Transmitral flow velocity variables are powerful predictors of poor prognosis in patients with left ventricular (LV) systolic dysfunction. However, these variables may not accurately reflect the severity of pulmonary congestion. This study was designed to determine whether the peak atrial systolic mitral annular motion velocity (MA-Aw) measured by pulsed Doppler tissue imaging can predict cardiac death or hospitalization for worsening heart failure in patients with LV systolic dysfunction. MA-Aw was recorded in 96 patients with LV systolic dysfunction who were followed up for 29 +/- 10 months. All patients underwent Doppler echocardiography on entry into the study, and cardiac catheterization was performed in 45 patients. Patients were divided into 3 groups on the basis of the ratio of early (E) to late (A) diastolic filling (E/A) of the transmitral flow velocity: group 1 (n=31; E/A < 1); group 2 (n=37; 1 < or = E/A < 2); and group 3 (n=28; E/A > or = 2). During follow-up, 36 patients (38%) died of cardiac causes and 34 (35%) were hospitalized for worsening heart failure. There were 2 cardiac deaths (6%) in group 1, 14 (39%) in group 2, and 20 (56%) in group 3. The MA-Aw correlated closely with the mean pulmonary capillary wedge pressure. Univariate Cox model analysis showed that MA-Aw < or = 5 cm/s was the most powerful predictor of cardiac death or hospitalization for worsening heart failure compared with clinical, hemodynamic, and the other echocardiographic variables. Furthermore, MA-Aw < or = 5 cm/s was clearly discernible as a good predictor of cardiac mortality on multivariate Cox model and as assessed by Kaplan-Meier method. The MA-Aw obtained by pulsed Doppler tissue imaging is a sensitive index of pulmonary congestion in patients with LV systolic dysfunction. It is a simple and noninvasive outcome measure and can be used to monitor treatment.


PMID: 12712015

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Bhakta, T.; Mandal, S.C.; Sanghamitra Sinha; Saha, B.P.; Pal, M., 2001: Evaluation of antipyretic potential of Cassia fistula bud extract. The antipyretic potential of Cassia fistula (collected from Agartala, Tripura, India), commonly known as Sundali, has been evaluated on the basis of its traditional uses and literature references. Methanol extract of buds of C. fistula was examine...

Pellmyr O., 1987: Temporal patterns of ovule allocation fruit set and seed predation in anemonopsis macrophylla ranunculaceae. Ovule deployment patterns were studied in Anemonopsis macrophylla Sieb, and Zucc. to develop hypotheses about major selective forces underlying different temporal strategies. Carpel number per flower decreased significantly with relative flowering...

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Tachibana, Y., 1971: Position of the median points of the face to the glabella-pogonion plane in Kumamoto inhabitants. Kumamoto Igakkai Zasshi. Journal of the Kumamoto Medical Society 45(8): 793-806

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von Kettler, J.; Glenig, W.R., 1978: Bilateral chronic disk-shaped macula edema with microaneurysms, diffuse vasculitis and cystic degeneration of the retina. Bericht Uber die Zusammenkunft. Deutsche Ophthalmologische Gesellschaft: 610-618