+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Progress with new malaria vaccines

, : Progress with new malaria vaccines. Bulletin of the World Health Organization 81(12): 902-909

Malaria is a parasitic disease of major global health significance that causes an estimated 2.7 million deaths each year. In this review we describe the burden of malaria and discuss the complicated life cycle of Plasmodium falciparum, the parasite responsible for most of the deaths from the disease, before reviewing the evidence that suggests that a malaria vaccine is an attainable goal. Significant advances have recently been made in vaccine science, and we review new vaccine technologies and the evaluation of candidate malaria vaccines in human and animal studies worldwide. Finally, we discuss the prospects for a malaria vaccine and the need for iterative vaccine development as well as potential hurdles to be overcome.


PMID: 14997243

Other references

Yang, R.; Zhang, H.; Xiong, Y.; Gui, X.; Zhang, Y.; Deng, L.; Gao, S.; Luo, M.; Hou, W.; Guo, D., 2017: Molecular diagnosis of central nervous system opportunistic infections and mortality in HIV-infected adults in Central China. CSF PCR is the standard diagnostic technique used in resource-rich settings to detect pathogens of the CNS infection. However, it is not currently used for routine CSF testing in China. Knowledge of CNS opportunistic infections among people living...

Scholz, Tás.; Aguirre-Macedo, M.Leopoldina.; Choudhury, A., 2004: Auriculostoma astyanace n. gen., n. sp. (Digenea: Allocreadiidae), from the banded astyanax, Astyanax fasciatus (Characiformes: Characidae), from Nicaragua, with a reevaluation of neotropical Crepidostomum spp. Auriculostoma n. gen. (Trematoda: Allocreadiidae) is proposed for Auriculostoma astyanace n. sp. from the intestine of the characid fish Astyanax fasciatus in the Atlantic coastal drainages of Nicaragua. The new genus differs from all papillose al...

Montero, J.A.; Ruiz-Moreno, J.M.; Sanabria, M.R.; Fernandez-Munoz, M., 2008: Efficacy of intravitreal and periocular triamcinolone associated with photodynamic therapy for treatment of retinal angiomatous proliferation. To compare the relative efficacy of photodynamic therapy (PDT), PDT associated with intravitreal triamcinolone (PDT-IT) and PDT associated with periocular triamcinolone (PDT-PT) for treatment of retinal angiomatous proliferation (RAP) stage III. R...

Domingues, M., 2006: Politicization and institutional unclarity: the case of the Portuguese food agency. Recent changes in the institutional framework of food safety in Portugal have been initiated by BSE scandals and by EU legislative impact. Portuguese consumers have only recently moved from a poverty-related fear of food scarcity to modern fears...

McKercher, P.D.; Farris, H.E., 1967: Foot-and-mouth disease in swine: response to inactivated vaccines. An enduring level of antibody was produced in pigs for 90 days by the inoculation of a trivalent vaccine combined with oil adjuvant. The antigenicity of the virus type determined, to a considerable degree, the antibody level attained. This relativ...

Ayoade, F.; Cotelingam, J.; Joel Chandranesan, A.Stevenson., 2017: Disseminated iMycobacterium avium -Intracellulare Complex Infection Presenting With Disseminated Intravascular Coagulation in an AIDS Patient. Disseminated <i>Mycobacterium avium</i>-intracellulare complex (MAC) infection is one of the relatively common opportunistic infections seen in severely immunocompromised AIDS patients. A constellation of clinical, laboratory, and path...

Weyers, H., 1983: Black tooth necks and tooth discolorations in children. What parents should know. Der Zahnarzt; Colloquium Med. Dent 27(11): 718-720

Chatterjee, H.G., 1891: Fatal Injury by a Stick Thrust into the Rectum. Indian Medical Gazette 26(8): 241-242

Erney, Diana, 1998: Coriander/cilantro. Coriander, a member of the Umbelliferae family, has been used in cooking since ancient times. The writer discusses how to grow coriander and the culinary and medical uses for the herb.

Li, D.; Huang, H.; Li, X.; Li, X., 2003: Hairpin formation in DNA computation presents limits for large NP-complete problems. Recently, several DNA computing paradigms for NP-complete problems were presented, especially for the 3-SAT problem. Can the present paradigms solve more than just trivial instances of NP-complete problems? In this paper we show that with high pro...