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Prostaglandin analogues for the treatment of glaucoma and ocular hypertension: a systematic review of economic evidence

, : Prostaglandin analogues for the treatment of glaucoma and ocular hypertension: a systematic review of economic evidence. Pharmacoeconomics 24(8): 743-750

We conducted a systematic review of economic studies of prostaglandin analogues for the treatment of glaucoma to assess the scope of current cost-effectiveness evidence and its relevance to decision-makers. The literature search retrieved 102 studies published before July 2005; after additional hand searching of conference proceedings, 13 full-text articles and 13 abstracts met the inclusion criteria. The reviewers extracted the key characteristics of each of the economic evaluations, and all studies received a grade in five categories to summarise the quality of the study: methodology, transparency, sensitivity, relevance and overall score. The current economic literature is predominantly focused on identifying the short-term direct cost of glaucoma treatment, particularly the precise quantification of glaucoma drug costs. Using the European and US treatment guidelines as a benchmark, it is evident that the current body of literature does not satisfy the needs of decision-makers, although certain studies provide some valuable information, which is a step towards reaching this goal. The main methodological issue in the economic models is an absence of a clinically relevant long-term effectiveness measure, or where this measure is produced, there is a lack of transparency and validation of the methods used. More attention needs to be given to modelling the consequences of treatment, and those consequences should include patient compliance, control of intraocular pressure and progression of visual field deficit, since these drive both the costs and the overall outcomes. We recognise that constructing the 'ideal' clinical outcome measure represents a major challenge to researchers. As such, we have outlined a modelling framework that could be used to produce the required level of economic evidence, and ongoing clinical research (such as the Early Manifest Glaucoma Trial) could provide the validated link between intraocular pressure and disease progression, which forms an essential part of such models.


PMID: 16898845

Other references

Beylot, M.; Soloviev, M., V.; David, F.; Landau, B., R.; Brunengraber, H., 1995: Tracing Hepatic Gluconeogenesis Relative to Citric Acid Cycle Activity in vitro and in vivo: Comparisons in the use of (3-13C)lactate, (2-13C)acetate, and alpha-keto(3-13C)isocaproate. The validity of the use of a carbon tracer for investigating liver intermediary metabolism in vivo requires that the labeling pattern of liver metabolites not be influenced by metabolism of the tracer in other tissues. To identify such specific tr...

Ledgard S.F.; Freney J.R.; Simpson J.R., 1984: Variations in natural enrichment of (super 15) N in the profiles of some Australian pasture soils. Australian Journal of Soil Research 22(2): 155-164

Barely, Henry Sir, 1870: Notes on the Fauna and Flora of Round Island. A few general remarks on birds of the locality (p. 121).

Lutgerath, F., 1959: Diagnosis & therapy of emphysema. Der Tuberkulosearzt 13(4): 274-279

Anonymous, 1955: Method and equipment for cheesemaking.. Cheese milk after the addition of rennet is poured into containers with an adequate capacity for making one cheese each, and is incubated at the appropriate temperature. When the coagulation is complete the contents are transferred, by inversion,...

Akhter, N.; Kobayashi, M.; Hoshino, T., 1993: Avian epidermis contains ATPase- and Ia-positive Langerhans-like cells. The occurrence of cells resembling mammalian Langerhans cells in the avian epidermis was studied by ATPase histochemistry, Ia immunoreactivity and electron microscopy. The existence of MHC class II antigen-(Ia) expressing, ATPase-positive dendriti...

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Karst, F.; Lacroute, F., 1973: Isolation of pleiotropic yeast mutants requiring ergosterol for growth. Mutant strains of Saccharomyces cerevisiae which require ergosterol for growth have been isolated. These mutants are all petite and require a fatty acid. Several mutants require methionine in addition. These mutants have been classified into 6 com...

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