+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Pulmonary hypertension in chronic dialysis patients with arteriovenous fistula: pathogenesis and therapeutic prospective

, : Pulmonary hypertension in chronic dialysis patients with arteriovenous fistula: pathogenesis and therapeutic prospective. Current Opinion in Nephrology and Hypertension 15(4): 353-360

End-stage renal disease patients receiving chronic haemodialysis via arteriovenous access often develop various cardiovascular complications, including vascular calcification, cardiac-vascular calcification and atherosclerotic coronary disease. This review describes recently published studies that demonstrate a high incidence of pulmonary hypertension among patients with end-stage renal disease receiving long-term haemodialysis via a surgical arteriovenous fistula. Both end-stage renal disease and long-term haemodialysis via arteriovenous fistula may be involved in the pathogenesis of pulmonary hypertension by affecting pulmonary vascular resistance and cardiac output. Morbidity and mortality from cardiovascular disease are greatly increased in patients on maintenance haemodialysis therapy. Using Doppler echocardiography, we found a significant increase in cardiac output in 40% of chronic haemodialysis patients, probably related to the large arteriovenous access or altered vascular resistance as a result of the local vascular tone and function expressed by the imbalance between vasodilators such as nitric oxide, and vasoconstrictors such as endothelin-1. We propose different potential mechanisms as explanations for the development of pulmonary hypertension. Hormonal and metabolic derangement associated with end-stage renal disease might lead to pulmonary arterial vasoconstriction and an increase in pulmonary vascular resistance. Pulmonary arterial pressure may be further increased by high cardiac output resulting from the arteriole-venous access itself, worsened by commonly occurring anaemia and fluid overload.


PMID: 16775448

DOI: 10.1097/01.mnh.0000232874.27846.37

Other references

Turgut, L.; Yanar, M., 2003: In situ dry matter and organic matter degradabilities of four different concentrates manufactured in Eastern Turkey. Different concentrates manufactured by commercial feed mills for ruminant nutrition in Eastern Turkey were investigated for dry matter and organic matter digestibilities and in situ dry and organic matter degradability kinetic parameters using thr...

Merton, V., 1982: Confidentiality and the "dangerous" patient: implications of Tarasoff for psychiatrists and lawyers. Emory Law Journal 31(2): 263-343

Terajima, M.; Urban, S.L.; Leporati, A.M., 2013: The N-terminus of vaccinia virus host range protein C7L is essential for function. <i>Vaccinia virus</i> (VACV), a member of the Poxviridae family of large double-stranded DNA viruses, is being used as a smallpox vaccine as well as an expression vector for immunization against other infectious diseases and cancer. Th...

Pan, Z-Yuan.; Ye, L.; Zhu, J.; DU.Z.Dong.; Huang, X-Guo.; Zhu, G-Qian.; Bao, W-Bin.; Wu, S-Long., 2011: Isolation of new alleles of the swine TLR4 gene and analysis of its genetic variation. Using the PCR-SSCP method, the genetic variation in exon 1 of the TLR4 gene was detected among 893 animals, including Asian wild boars, 3 imported commercial and 10 Chinese indigenous swine breeds. This was conducted to analyze the polymorphisms o...

Keeley, J.; Walker, C.1; Mathews, R., 1983: Crassulacean acid metabolism in Isoetes bolanderi in high elevation oligotrophic lakes California, diurnal changes, photosynthesis, seasonal effects. Oecologia 8(1): 63-69

Miquelis, R.; Manivet, M.; Simon, C., 1977: Heterogeneity of thyroid lysosomes and secretion. In order to establish a relationship between the preferential secretion of young molecules and the endocytosis process, double labeling experiments with 131I (new label) and 125I (old label) were performed on rats. The specific radioactivity (SRA...

Tranter, R.S.; Lynch, P.T.; Annesley, C.J., 2012: Shock tube investigation of CH3 + CH3OCH3. The title reaction has been investigated in a diaphragmless shock tube by laser schlieren densitometry over the temperature range 1163-1629 K and pressures of 60, 120, and 240 Torr. Methyl radicals were produced by dissociation of 2,3-butanedione...

Fan, Y.; Avci, N.G.; Nguyen, D.T.; Dragomir, A.; Akay, Y.M.; Xu, F.; Akay, M., 2015: Engineering a High-Throughput 3-D In Vitro Glioblastoma Model. Glioblastoma multiforme (GBM) is the most common and malignant primary brain tumor in adults because of its highly invasive behavior. The existing treatment for GBM, which involves a combination of resection, chemotherapy, and radiotherapy, has a...

Berry, D.M.; Williams, K.; Meckling Gill, K.A., 1996: All-trans retinoic acid induces apoptosis in NB4 cells when combined with 1,25-alpha dihydroxyvitamin D-3 or isoquinolinediol. Proceedings of the American Association for Cancer Research Annual Meeting 37(0): 19

Shen, B.; Targowski, P.; Lobo, J.; Davenport, L., 1994: Effects of peptides on submicrosecond lipid dynamics using long-lived fluorescence probes. Biophysical Journal 66(2 PART 2): A58