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Qualitative assessment of selective blockade of M(4)-cholinoreceptors in the whole organism

, : Qualitative assessment of selective blockade of M(4)-cholinoreceptors in the whole organism. Bulletin of Experimental Biology and Medicine 135(5): 445-446

Quantitative assessment of selective blockade of M4-subtype muscarinic receptors was performed by the number of pilocarpine-induced movements of lower jaw in rats. Three antagonists (atropine, cyclodol, and glipin) were used in the experiments. Glipin produced the most potent blockade of M4 receptors in the whole organism compared to other test antagonist.


PMID: 12910282

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