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Recent advances in research on Parkinson disease: synuclein and parkin

, : Recent advances in research on Parkinson disease: synuclein and parkin. Neurologist 10(2): 75-81

Until recently, most research effort on Parkinson disease (PD) was focused on possible environmental causes. With the discovery of mutations in two genes, synuclein and parkin, which are responsible for rare familial forms of the disease, there has been a major change in emphasis. The first genetic cause of PD to be identified was in the gene for synuclein, resulting in an alanine to threonine substitution at position 53. The likely pathogenetic significance of this mutation was supported by the discovery of a second mutation, and the presence of synuclein in Lewy bodies in sporadic PD cases. The synuclein protein has a tendency to self aggregate, and this tendency is increased in the mutants, and by oxidative injury to the protein. While there is growing evidence in animal models that overexpression of wildtype or mutant synuclein may lead to intracytoplasmic inclusions, and dysfunction of dopamine neurons, no animal models in rodents have yet replicated all important features of the disease. Deletions or point mutations in the gene for parkin cause an autosomal recessive, early onset form of parkinsonism. The parkin protein functions as an E3 ubiquitin-protein ligase, and it is involved in the degradation of cellular proteins by the proteasomal pathway. It is hypothesized that the loss of this function results in the toxic accumulation of its target proteins. Research on these inherited forms of PD is pointing towards a common theme, that disturbances of cellular protein handling can lead to the death of dopamine neurons in PD.


PMID: 14998437

Other references

Labanaris, A.P.; Zugor, V.; Smiszek, R.; Nützel, R.; Kühn, R.; Engelhard, K., 2011: Guided e-MRI prostate biopsy can solve the discordance between Gleason score biopsy and radical prostatectomy pathology. The aim of this study is to examine if guided prostate biopsies based on abnormalities detected by conventional and functional endorectal magnetic resonance imaging (MRI) yield a more reliable representation of the radical prostatectomy pathology...

Kishore, A.; Popa, T.; James, P.; Yahia-Cherif, L.; Backer, F.; Varughese Chacko, L.; Govind, P.; Pradeep, S.; Meunier, S., 2015: Age-related decline in the responsiveness of motor cortex to plastic forces reverses with levodopa or cerebellar stimulation. The plasticity of motor cortex is integral for motor memory and skills acquisition but it declines with aging. Forty healthy volunteers, across 6 decades, were tested to examine the (a) age-dependency of motor cortex responsiveness to plasticity i...

Williams, W.L., 1946: Mammary structure and secretion in premature and full-term infants. After the 28th to 30th week of gestation the fetal mammary parenchyma, which previously consisted of solid epithelial cords, formed ducts. Mammary secretion was noted 24 to 72 hr. post partum in premature infants born after the 27th week of gestat...

Barbosa, J.A.R.G.; Pinheiro, C.B.silio; Alves, A.C.; Brandao Neto, J.R.; Alonso, L.G.; Gay, G.; Polikarpov, I., 2001: Crystallization and X-ray data analysis of the extended DNA-binding domain of the E2 Bovine Papillomavirus Type 1 protein. Hanging-drop vapour-diffusion method was used for the crystallization of the extended DNA-binding domain (residues 309-410) of the E2 protein from Bovine Papillomavirus Type 1. X-ray data collection at 2.0 ANG resolution was performed using synchr...

Edwards, H.; Gessner, R., 1985: Ultrastructure of English oak mycorrhizal cystidia. Proceedings of the 6th North American Conference on Mycorrhizae: June 25-29-1984 Bend Oregon compiled and edited by Randy Molina sponsoring institutions Oregon State University College of Forestry and USDA

Aoyama, Junzo, 1995: A note on Bonins cicada Meimuna boninensis. Nature & Insects 30.1: 25-32

Maldonado Leon, K.I.; Hernandez, O.H., 2001: Estudio electrofisiologico en el cerebro del cangrejo cangrejo moro (Menippe mercenaria) semi-intacto, no anestesiado ni restringido. In this study we demonstrated the feasibility to get brain electrical recordings from one unanesthetized and unrestrained marine crab under such conditions that conserve intact its vascular, neural and neuroendocrine systems. We found that spontan...

Chouhdary R.; Neil D.M., 1987: The effects of vertical semicircular canals on responses of dogfish extraocular muscles to tilts in different vertical planes. Journal of Physiology (Cambridge) 392: 65P

Pinette, M.G.; Pan, Y.; Chard, R.; Pinette, S.G.; Blackstone, J., 1998: Prenatal diagnosis of nonmosaic trisomy 9 and related ultrasound findings at 11.7 weeks. Trisomy 9 is a relatively rare chromosomal abnormality. There have been no reports of first trimester ultrasound findings associated with mosaic or nonmosaic trisomy 9 in the literature. A case of nonmosaic trisomy 9 diagnosed prenatally with ultr...

Corr L.; Grounds R.M.; Brown M.J.; Whitwam J.G., 1986: Plasma catecholamine changes during cardiopulmonary bypass a randomized double blind comparison of trimetaphan camsylate and sodium nitroprusside. The effects of trimetaphan camsylate and sodium nitroprusside on the catecholamine response to cardiac surgery were compared in a randomised double blind study of twelve male patients undergoing elective myocardial revascularisation. The solution...