geoscience.net logo
+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Relationship between glucocorticoid-induced osteoporosis and vitamin D receptor genotypes


, : Relationship between glucocorticoid-induced osteoporosis and vitamin D receptor genotypes. Journal of Huazhong University of Science and Technology. Medical Sciences 22(4): 317-9, 323

By means of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay, the association between vitamin D receptor (VDR) genotypes and bone mineral density (BMD) in the patients receiving long-term glucocorticoid therapy was studied. The clinical data and blood of 71 patients with rheumatosis who received long-term glucocorticoid therapy were collected. BMD was measured by dual-energy X-ray absorptimometry. VDR gene fragment (about 185 bp) was amplified by PCR from the extracted genomic DNA, then digested with restriction endonuclease Bsm I. The genotypes were evaluated based on the fragment length following endonuclease digestion and the association between genotypes and BMD or Z-score values was analyzed. Among the 71 cases, the detected genotypes were Bb and bb with the distribution frequency being 11.3% and 88.7% respectively. The distribution frequency of the alleles was in agreement with the Hardy-Weinberg equilibrium. There was no significant difference between the two genotypes in age, gender, body mass index (BMI), disease duration, disease types, time of glucocorticoid administration and cumulative dosage (P > 0.05). Osteoporosis rate of the patients with Bb or bb genotype was 37.5% and 33.3% respectively, with the difference being not significant (chi 2 = 0.05, P = 0.8). The BMD and Z-score values at lumbar spine and femur in two genotypes were not similar, but the difference had no significant (P > 0.05). The distribution frequency of bb type of VDR genotypes in Han populations of China was more prevalent, followed by Bb and bb types in turn. In the patients receiving long-term glucocorticoid therapy, there was no significant difference in BMD between Bb and bb genotypes. The data suggest that the VDR genotypes may not be means of identifying patients at greater risk of glucocorticoid-induced osteoporosis, which await to be further confirmed by a large sample size.

US$29.90

PMID: 12674768


Other references

Perry, G.A.; Smith, M.F.; Lucy, M.C.; Green, J.A.; Parks, T.E.; MacNeil, M.D.; Roberts, A.J.; Geary, T.W., 2005: Relationship between follicle size at insemination and pregnancy success. Administration of gonadotropin-releasing hormone (GnRH) induces a surge of luteinizing hormone and ovulation in a variety of species, including human beings. Our objectives were to determine the effect of follicle size at the time of ovulation on...

Iyer, V.; Rowbotham, S.; Biros, E.; Bingley, J.; Golledge, J., 2017: A systematic review investigating the association of microRNAs with human abdominal aortic aneurysms. There is increasing interest in identifying novel methods for abdominal aortic aneurysm (AAA) diagnosis. Non-coding RNA molecules such as microRNAs (miRNAs) are stable within the circulation and may serve as biomarkers for AAA. This systematic rev...

Nanduri, V.R.; Stanhope, R., 1999: Why is the retention of gonadotrophin secretion common in children with panhypopituitarism due ot septo-optic dysplasia?. Septo-optic dysplasia (De Morsier syndrome) is a developmental anomaly of mid-line brain structures and includes optic nerve hypoplasia, absence of the septum pellucidum and hypothalamo-pituitary abnormalities. We describe seven patients (four fem...

Tashima, Y.; Nakajima, K., 2008: Numerical experiment on the excitation of acoustic waves by convective clouds related to the free oscillation of the Earth. Japan Geoscience Union Meeting

Zhu, Y.C.; An, T.; Liu, Y.; Zhang, Z.L.; Yang, Q.B., 2017: Immunoprotective effects of a hemin-binding peptide derived from hemagglutinin-2 against infection with Porphyromonas gingivalis. The principal etiologic agent in periodontal disease, Porphyromonas gingivalis, generates cysteine proteases that bind heme with domains such as hemagglutinin-2 (HA2). High-affinity HA2-hemin binding supplies the porphyrin and ferric iron needed f...

Dominici, M.; Gomes, M.da.Mota., 2010: Obstructive sleep apnea (OSA) and depressive symptoms. The relationship between obstructive sleep apnea (OSA) and depressive symptoms is ambiguous in the literature. To investigate if there is a correlation between depressive symptoms and the severity of OSA. A retrospective, cross-sectional study of...

Wilden, H.; Fournier, P.; Zawatzky, R.; Schirrmacher, V., 2009: Expression of RIG-I, IRF3, IFN-beta and IRF7 determines resistance or susceptibility of cells to infection by Newcastle Disease Virus. Newcastle Disease Virus (NDV) is an avian paramyxovirus with anti-neoplastic and immune-stimulatory properties which has raised considerable interest for cancer therapy. To better understand the molecular nature of the tumor selective replication...

Villa, P.; Soriano, S.; Tsanova, T.; Degano, I.; Higham, T.F.G.; d'Errico, F.; Backwell, L.; Lucejko, J.J.; Colombini, M.Perla.; Beaumont, P.B., 2012: Border Cave and the beginning of the Later Stone Age in South Africa. The transition from the Middle Stone Age (MSA) to the Later Stone Age (LSA) in South Africa was not associated with the appearance of anatomically modern humans and the extinction of Neandertals, as in the Middle to Upper Paleolithic transition in...

Baker, H.B.; Passipieri, J.A.; Siriwardane, M.; Ellenburg, M.D.; Vadhavkar, M.; Bergman, C.R.; Saul, J.M.; Tomblyn, S.; Burnett, L.; Christ, G.J., 2017: Cell and Growth Factor-Loaded Keratin Hydrogels for Treatment of Volumetric Muscle Loss in a Mouse Model. Wounds to the head, neck, and extremities have been estimated to account for ∼84% of reported combat injuries to military personnel. Volumetric muscle loss (VML), defined as skeletal muscle injuries in which tissue loss results in permanent func...

Tsukamoto, Y., 2010: Growing initiative by the Asian Forum of CKD Initiative (AFCKDI): the report of International Advisory Council/Work Group Meeting. Nephrology 15 Suppl 2: 1-2