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Replacing maximum-tolerated medications with latanoprost versus adding latanoprost to maximum-tolerated medications: a two-center randomized prospective trial

, : Replacing maximum-tolerated medications with latanoprost versus adding latanoprost to maximum-tolerated medications: a two-center randomized prospective trial. Journal of Glaucoma 12(4): 347-353

To compare the replacement of every drug with latanoprost 0.005% once a day in glaucomatous eyes with poorly controlled intraocular pressure upon combination therapy, versus addition of latanoprost to the pre-existing treatment. prospective, investigator-masked, two-center, randomized clinical trial lasting 3 months. open-angle glaucoma; IOP > or = 21 mm Hg upon the combination of a non-selective beta-blocker with pilocarpine or dorzolamide or both; no previous bulbar surgery; and prior glaucoma therapy lasting at least 2 years. Two treatment arms: (1) addition of latanoprost 0.005% QD to the pre-existing therapy [group A]; (2) substitution with latanoprost alone [group B]. One hundred thirty-six eyes (68 eyes/treatment group) were randomized according to intraocular pressure level and the number of adjunctive medications to beta blocker. Both treatments provided a significant IOP decrease over baseline (from 23.5 +/- 1.4 to 19.7 +/- 1.9 mm Hg in group A, (P < 0.001); from 23.2 +/- 1.3 to 20.1 +/- 2.2 mm Hg in group B (P < 0.001), paired Student t test). At the end of the follow-up period, group A showed a higher number of intraocular readings less than or equal to 18 mm Hg than group B (42.6% vs. 30.8%; Fisher exact test: P = 0.018). In eyes showing an intraocular pressure greater than 21 mm Hg upon combination therapy, the substitution of the pre-existing treatment with latanoprost can provide a significant IOP decrease. However, adding latanoprost to the pre-existing therapy is more likely to achieve a target intraocular pressure less than or equal to 18 mm Hg.


PMID: 12897580

Other references

Graham, L.A.; Noseworthy, L.; Fugler, D.; O'Leary, K.; Karman, D.; Grande, C., 2004: Contribution of vehicle emissions from an attached garage to residential indoor air pollution levels. The infiltration of vehicle emissions into a house from the attached garage was studied for 16 homes of differing designs using the same extensively characterized vehicle at each home. Before the in-home measurement program, the cold-start and hot...

Topoff, H.C.ver, S.G.eenberg, L.G.odloe, L.S.erman, P., 1988: Colony founding by queens of the obligatory slave-making ant, Polyergus breviceps: the role of the Dufours gland. Ethology 78(3): 209-218

Olson, R.E.; Maduskuie, T.P.; Thompson, L.A.drew; Tebben, A.J.; Wang, N.; Deng, W.; Liu, H., 2003: Succinoylamino carbocycles and heterocycles as inhibitors of a-beta protein production. This invention relates to novel carbocycles and heterocycles having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specif...

Yu, C.; Hequn, C.; Longfei, L.; Long, W.; Zhi, C.; Feng, Z.; Jinbo, C.; Chao, L.; Xiongbing, Z., 2016: GSTM1 and GSTT1 polymorphisms are associated with increased bladder cancer risk: Evidence from updated meta-analysis. Previous studies have indicated association between GSTM1 and GSTT1 gene polymorphisms and bladder cancer susceptibility, but the results have been inconclusive. Here, we performed a meta-analysis to investigate the association between GSTM1/GSTT1...

Batista, M. de F.; Bolkan, H.A., 1982: Oversprouting of guarana. Numerous sprouts formed an irregular, dense mass on the trunk and branches [of Paullinia cupana]. Fusarium decemcellulare [Calonectria rigidiusculs] was isolated. Visual2symptoms appeared 30-40 days after inoculation.

Martins, T., 1937: A rapid test for the. CLEAR results may be obtained in 24 hrs. if injection of the hormone to castrated animals is followed 14 hrs. later by an injection of colchicine (0.025-0.l mg. per kg. for mice, 2-3 mg. for rats), which has the property of arresting the process o...

Xie, X-Lan.; Huang, Q-Sheng.; Gong, M.; Du, J.; Yang, Y.; Chen, Q-Xi., 2008: Inhibitory kinetics of beta-N-acetyl-D-glucosaminidase from prawn (Litopenaeus vannamei) by zinc ion. Prawn (Litopenaeus vannamei) beta-N-acetyl-D-glucosaminidase (NAGase, EC is involved in the digestion and molting processes. Zinc is one of the most important metals often found in the pollutant. In this article, the effects of Zn(2+) on...

Savory J.; Lee S.; Johns M.E.; Johnson J.; Wills M.R., 1982: Erythrocyte poly amines in monitoring treatment in patients with head and neck cancer. Clinical Chemistry 28(7): 1582

Shakirzyanova, A.; Valeeva, G.; Giniatullin, A.; Naumenko, N.; Fulle, S.; Akulov, A.; Atalay, M.; Nikolsky, E.; Giniatullin, R., 2016: Age-dependent action of reactive oxygen species on transmitter release in mammalian neuromuscular junctions. Reactive oxygen species (ROS) are implicated in aging, but the neurobiological mechanisms of ROS action are not fully understood. Using electrophysiological techniques and biochemical assays, we studied the age-dependent effect of hydrogen peroxid...

Onoe, H.; Itonaga, Y.; Ito, Y., 2001: Interaction of immunophilin FKBP and intracellular Ca2+ release channels. Fukuoka Igaku Zasshi 92(7): 272-277