+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Rimonabant: a selective blocker of the cannabinoid CB1 receptors for the management of obesity, smoking cessation and cardiometabolic risk factors

, : Rimonabant: a selective blocker of the cannabinoid CB1 receptors for the management of obesity, smoking cessation and cardiometabolic risk factors. Expert Opinion on Investigational Drugs 15(3): 307-315

Rimonabant is the first selective blocker of the cannabinoid CB1 receptors being developed for the treatment of obesity, tobacco smoking and cardiometabolic risk factors. Following 1 year of treatment, rimonabant 20 mg/day leads to greater weight loss compared with placebo. Therapy with rimonabant is also associated with favourable changes in serum lipids and an improvement in glycaemic control in Type 2 diabetics. At the same dose, rimonabant significantly increases the cigarette smoking quit rates compared with placebo. Rimonabant appears to be generally well tolerated, with primary side effects of mild nausea, diarrhoea, anxiety and depression. As an agent with a novel mechanism of action, rimonabant has the potential to be a useful adjunct to lifestyle modification in the treatment of obesity, metabolic syndrome and cigarette smoking.


PMID: 16503766

DOI: 10.1517/13543784.15.3.307

Other references

Majsurjan, M.\n. A.; Firsov, I.P.; Majsurjan, M.B.lysev, B.\l. N., 1970: Genetical and breeding investigations on hybridization of different varieties and forms of beets. Data are presented showing the percentages of hybrid seedlings obtained when diploid or tetraploid sugar beets were grown in mixtures with mangel cultivars in proportions varying from 1: 1 to 4: 1. With sugar beet as seed parent, a higher proporti...

Baker, K.B.; Kim, J.J., 2004: Amygdalar lateralization in fear conditioning: evidence for greater involvement of the right amygdala. The relative contribution of left and right amygdalae in the acquisition and retention of fear conditioning was investigated in rats. Pretraining bilateral electrolytic lesions blocked the acquisition of conditioned fear to tone and context, where...

Bazzani, C.; Mioni, C.; Ferrazza, G.; Cainazzo, M.Michela.; Bertolini, A.; Guarini, S., 2002: Involvement of the central nervous system in the protective effect of melanocortins in myocardial ischaemia/reperfusion injury. Melanocortin peptides exert, in rats, a protective effect in myocardial ischaemia followed by reperfusion, or permanent occlusion of a coronary artery. Moreover, melanocortins have an anti-shock effect. Since the mechanism of the life-saving effec...

Sakai, F., 2005: Mechanism based prevention and treatment of migraine. Triptan therapy results in good relief of headache in 68% of the patients. For many of the patients with migraine, triptan provides complete pain relief in some attacks but not in others. A recent theory proposes that allodynia (pain sensitization...

Pauli, P.; Bourne, L.E.Jr.; Braun, C.; Kinsces, E.; Lutzenberger, W.; Birbaumer, N., 2000: Prefrontal brain activity recorded with MEG during a target finding process. Psychophysiology 37(Supplement 1): S77, August

Patterson, P., 1991: Hospitals are catering to working mothers. Or Manager 8(1): 15-15

Nakchbandi, I.A.; Masiukiewicz, U.; Mitnick, M.; Lang, R.; Kinder, B.; Insogna, K.L., 2002: The relationship of serum RANKL to bone resorption in states of acute and chronic parathyroid hormone excess. Journal of Bone & Mineral Research 17(Suppl 1): S382, September

Miller, P.; Chilvers, C.; Dewey, M.; Fielding, K.; Gretton, V.; Palmer, B.; Weller, D.; Churchill, R.; Williams, I.; Bedi, N.; Duggan, C.; Lee, A.; Harrison, G., 2003: Counseling versus antidepressant therapy for the treatment of mild to moderate depression in primary care: economic analysis. To compare the cost-effectiveness of generic psychological therapy (counseling) with routinely prescribed antidepressant drugs in a naturalistic general practice setting for a follow-up period of 12 months. Economic analysis alongside a randomized...

Bachhav, Y.G.; Kalia, Y.N., 2010: Development and validation of an analytical method for the quantification of cytochrome c in skin transport studies. A simple isocratic HPLC method for the quantification of Cytochrome c in skin permeation samples was developed and validated. The mobile phase comprised a 41 : 59 mixture of an organic phase A (0.1% trifluoroacetic acid in a 90 : 10 mixture of MeC...

Guppy, J.C.; Harcourt, D.G., 1970: Spatial pattern of the immature stages and teneral adults of Phyllophaga spp. (Coleoptera: Scarabaeidae) in a permanent meadow. The following is based largely on the authors' abstract. Data from random counts of all stages of Lachnosterna (Phyllophaga) fusca (Froel.) and L, (P). anxia (Lec.) in a permanent meadow in western Quebec during 1962-69 did not conform to the...