+ Resolve Article
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter

+ Translate
+ Subscribe to Site Feed
GeoScience Most Shared ContentMost Shared Content

Room temperature ring-opening metathesis of pyridines by a transient Ti[triple bond]C linkage

, : Room temperature ring-opening metathesis of pyridines by a transient Ti[triple bond]C linkage. Journal of the American Chemical Society 128(21): 6798-6799

The transient titanium alkylidyne complex (PNP)TiCtBu (PNP = N[2-P(CHMe2)2-4-methylphenyl]2-), prepared from alpha-hydrogen abstraction of the corresponding alkylidene-alkyl species (PNP)Ti=CHtBu(CH2tBu), can readily cleave the C-N bond of N-heterocycles such as pyridine and 4-picoline at room temperature to afford azametallabicyclic systems. Experimental and theoretical studies strongly favor a ring-opening metathesis pathway where [2 + 2] cycloaddition of pyridine across the TiC linkage ultimately leads to C-N bond rupture.


PMID: 16719454

DOI: 10.1021/ja061590p

Other references

Dyson, L.; Stolk, W.A.; Farrell, S.H.; Hollingsworth, T.Déirdre., 2017: Measuring and modelling the effects of systematic non-adherence to mass drug administration. It is well understood that the success or failure of a mass drug administration campaign critically depends on the level of coverage achieved. To that end coverage levels are often closely scrutinised during campaigns and the response to underperf...

Augustsson Carita; Bahlburg Heinrich; Berndt Gerdes Jasper, 2007: Detrital zircons as provenance indicators; the Middle Ordovician Lower Turbidite System, NW Argentina. Geochimica et Cosmochimica Acta 71(15S): A44

Li, M.J.n; Guo Jun Hua; X.Z.uo Li, 1996: Prevention of hematopoietic toxicity of cisplatin by biosynthesis metallothionein. Cisplatin can cause hematological toxicity which can be reduced by tissue metallothionein (MT). The protective effect of trace compounds glycyrrhizate (Gly-Zn), se-malt and Na-2SeO-3 by way of inducing MT synthesis as well as hematological toxicit...

Pats, P.; Ekbom, B.; Skovgard, H., 1997: Influence of intercropping on the abundance, distribution and parasitism of Chilo spp. (Lepidoptera: Pyralidae) eggs. Two of the most common and serious pests of maize and sorghum in the coastal areas of East Africa are the pyralid species, Chilo partellus (Swinhoe) and C. orichalcociliellus (Strand). Maize monocrop (with high and low plant density) and maize/cow...

Zakirulla, M.; Uloopi, K.S.; Subba Reddy, V.V., 2012: In vivo comparison of reduction in bacterial count after caries excavation with 3 different techniques. The purpose of this in vivo study was to evaluate and compare the reduction in bacterial count in dentin after caries excavation with a spoon excavator, carbide bur, and polymer bur. Forty-five primary molar teeth from 36 children with occlusal de...

Khan, M.Ashrafuddin.; El-Gamal, M.I.; Tarazi, H.; Choi, H.Seok.; Oh, C-Hyun., 2016: Design and synthesis of a new series of highly potent RAF kinase-inhibiting triarylpyrazole derivatives possessing antiproliferative activity against melanoma cells. Inhibition of V600E-B-RAF kinase represents a potential avenue for melanoma treatment. Herein, a series of 1,3,4-triarylpyrazoles possessing amide linker were designed, synthesized and evaluated for RAF kinase inhibition. Compounds 1d and 1f were...

Targownik, L.E.; Lix, L.M.; Leung, S.; Leslie, W.D., 2010: Proton-pump inhibitor use is not associated with osteoporosis or accelerated bone mineral density loss. Recent studies have shown an association between proton-pump inhibitor use (PPI) and hip fracture. The mechanism by which PPI use promotes the development of hip fracture is uncharacterized. Therefore, we sought to determine whether PPI use is ass...

Bellavia, L.; Kim-Shapiro, D.B.; King, S.Bruce., 2016: Detecting and monitoring NO, SNO and nitrite iin vivo. NlmCategory="UNASSIGNED">The detection and quantification of nitric oxide and related reactive nitrogen species <i>in vivo</i> is vital to the understanding of the pathology and/or treatment of numerous conditions. To that...

Meijer S.; Visser J.J.; Hoitsma H.F.W.; Rauwerda J., 1980: The effects of selective proximal vagotomy and of truncal vagotomy on bile composition. European Surgical Research 12(SUPPL 1): 59-60

Klein, W.M.; Wilentz, R.E.; Klein Szanto, A.J.P.; Hruban, R.H., 2001: Direct correlation between proliferative activity and dysplasia in pancreatic intraepithelial neoplasia Additional evidence for a recently proposed model of progression. Laboratory Investigation 81(1): 198A, January