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Safety of paracetamol as a representative of nonprescription analgetics-antipyretics

, : Safety of paracetamol as a representative of nonprescription analgetics-antipyretics. Klinicheskaia Meditsina 81(4): 58-60

Paracetamol is a well-known analgetic-antipiretic drug widely used in medical practice. In therapeutic doses (4 g/day for adults and 60 mg/kg/day for children) paracetamol relieves fever and non-severe pain with minimal risk of complications both in adults and children. But medical professionals should know that in extremely high doses (above 10 g for adults) paracetamol has a hepatotoxic effect. Overdose intake of paracetamol in Russia happens rarely, it occurs by chance or in attempted suicide. In such a case the antidote must be used to protect the liver. This antidote for paracetamol is N-acetylcysteine.


PMID: 12785227

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