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Saxitoxin, a toxic marine natural product that targets a multitude of receptors


, : Saxitoxin, a toxic marine natural product that targets a multitude of receptors. Natural Product Reports 23(2): 200-222

Saxitoxin (STX) was discovered early last century and can contaminate seafood and drinking water, and over time has become an invaluable research tool and an internationally regulated chemical weapon. Among natural products, toxins obtain a unique reputation from their high affinity and selectivity for their target pharmacological receptor, which for STX has long been considered to only be the voltage gated sodium channel. In recent times however, STX has been discovered to also bind to calcium and potassium channels, neuronal nitric oxide synthase, STX metabolizing enzymes and two circulatory fluid proteins, namely a transferrin-like family of proteins and a unique protein found in the blood of pufferfish.

US$19.90

PMID: 16572228

DOI: 10.1039/b501296c


Other references

Nisa-Martínez, R.; Laporte, P.; Jiménez-Zurdo, Jé.Ignacio.; Frugier, F.; Crespi, M.; Toro, Nás., 2014: Localization of a bacterial group II intron-encoded protein in eukaryotic nuclear splicing-related cell compartments. Some bacterial group II introns are widely used for genetic engineering in bacteria, because they can be reprogrammed to insert into the desired DNA target sites. There is considerable interest in developing this group II intron gene targeting tec...

Varon, M.; Seijffers, J., 1975: Symbiosis-independent and symbiosis-incompetent mutants of Bdellovibrio bacteriovorus 109J. Symbiosis-independent (Sin) mutants were isolated from the symbiosis-dependent and symbiosis-competent (Sdcomp+) Bdellovibrio bacteriovorus 109J. Independently isolated Sin mutants were examined for their symbiosis competence and most were found t...

Mitolo, M.; D.F.lice, F.; Ruccia, D.; Terlizzi, L.; Camassa, M.C.; Terlizzi, F., 1954: ElectrocortiVoL 25, No. 3 cograms of the albino rat deprived of individual members of the vitamin B complex. Readings with the electrocorticograph were made on young male rats weighing from 45 to 55 g. at the beginning of the experiment. The rats were maintained on a normal diet, or on a complete purified diet with or without omission of individual B vit...

Panet, H.; Barzilai, A.; Daily, D.; Melamed, E.; Offen, D., 2001: Activation of nuclear transcription factor kappa B (NF-kappaB) is essential for dopamine-induced apoptosis in PC12 cells. The etiology of Parkinson's disease is still unknown, though current investigations support the notion of the pivotal involvement of oxidative stress in the process of neurodegeneration in the substantia nigra (SN). In the present study, we i...

Baklaushev, V.P.; Kardashova, K.Sh.; Gurina, O.I.; Leopol'd, A.V.; Semenova, A.V.; Ryabukhin, I.A.; Chekhonin, V.P., 2012: Cloning and expression of brain-specific anion transporter BSAT1 and isolation of monoclonal antibodies to its extracellular fragment. Brain-specifi c anion transporter BSAT1 extracellular fragment (451-557) cDNA was cloned in a vector for prokaryotic expression, a producer <i>E. coli</i> strain was obtained, and recombinant extracellular fragment BSAT1<sub>451-...

Gianfaldoni, S.; Gianfaldoni, R.; Wollina, U.; Lotti, J.; Tchernev, G.; Lotti, T., 2017: An Overview on Radiotherapy: From Its History to Its Current Applications in Dermatology. For more than a century, radiotherapy has been an effective treatment for oncologic patients. The Authors report a brief history of the radiation therapy and its actual indication for the treatments of cutaneous malignant diseases.

Welsh, R.C.; Zeymer, U.; Tarrantini, G., 2016: Direct oral anticoagulant use and stent thrombosis following an acute coronary syndrome: A potential new pharmacological option?. With the evolution of techniques and pharmacological strategies in percutaneous coronary intervention, significant advances have been made towards reducing the risk of in-stent restenosis and improving patient outcomes. However, in spite of these...

Prevett P.F.; Benton F.P.; Hall D.R.; Hodges R.J.; Serodio R.D.S., 1989: Suppression of mating in ephestia cautella walker lepidoptera phycitidae using microencapsulated formulations of synthetic sex pheromone. The suppression of mating in Ephestia cautella caused by permeation of the atmosphere with the synthetic sex pheromone component (Z, E)-9,12-tetradecadienyl acetate (ZETA), dispensed from thin- and thick-walled microcapsules or polyethylene vials,...

Rodriguez-Minon, J.L., 1958: Dietetic plan for therapy of uncomplicated diabetes. Revista Clinica Espanola 71(1): 52-55

Wakefield, R.J.; Gibbon, W.W.; Emery, P., 1999: The current status of ultrasonography in rheumatology. Rheumatology 38(3): 195-198